Sympathetic influences on circulation of the gastric mucosa of the rat

Arabehety, Julian T.; Dolcini, Horacio A.; Gray, Seymour J.

doi:10.1152/ajplegacy.1959.197.4.915

Cited by 21 publications

(1 citation statement)

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“…It has been reported that gastric mucosal blood flow (GMBF) significantly decreases in almost all portions of the stomach at the active stage of ulcer formation [10,11], just after the development of gastric ulcers [12], and returns to the same level as normal con trols at the healing and scarring stages [3,13]. Thus, GMBF was thought to be one of the most important defensive factors in the devel opment of gastric injuries.…”

Section: Discussionmentioning

confidence: 99%

DQ-2511 Having an Antiulcer Action, Elicits Vasodilation through an Increase in Cyclic GMP Contents in Rat Arteries

Hatanaka¹,

Ryokawa²,

Kawarabayashi³

et al. 1995

Pharmacology

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It has been reported that 3-({[2-(3,4-dimethoxyphenyl)ethyl]carbamoyl}methyl)amino-N-methylbenzamide (DQ-2511: ecabapide) effectively increases gastric mucosal blood flow in rats, suggesting that this property may contribute to the antiulcer activity. To clarify the mechanisms underlying the increase in gastric mucosal blood flow, we investigated the dilator response of rat isolated thoracic aorta, mesenteric artery and celiac artery smooth muscle preparations to DQ-2511. This compound prevented noradrenaline-induced contraction in both the presence and absence of endothelium in the arterial specimen, and it (0.01–1 mM) inhibited these contractions induced by noradrenaline in all tissues in a concentration-dependent manner. This inhibitory effect of DQ-2511 was most evident in the celiac artery. The dilator response to DQ-2511 (0.1 mM) was abolished after pretreatment with methylene blue (3 µM), a guanylate cyclase inhibitor. Under the same conditions, methylene blue inhibited the dilator response to acetylcholine (1 µAf), but not that to papaverine (10 µM). Furthermore, when DQ-2511 (0.01–1 mM) was incubated with the arterial preparations, this compound increased cyclic GMP content in segments in a concentration-dependent manner. These findings demonstrate that the vasodilation induced by DQ-2511 is independent of the endothelium and is related to the augmentation of intracellular cyclic GMP content, which may consequently contribute to the increased gastric mucosal blood flow.

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Section: Discussionmentioning

confidence: 99%