Sympathetic ophthalmia after vitreoretinal surgery: a report of two cases

Abstract

Sympathetic ophthalmia (SO) is a panuveitis that usually occurs after trauma to one eye. We describe two cases of SO occurring after 23-gauge vitrectomy. Case 1 involved a 66-year-old woman who underwent pars plana vitrectomy (PPV) for a rhegmatogenous retinal detachment. Two months later, she presented with decreased visual acuity (VA) and bilateral uveitis. Case 2 involved a 43-year-old woman who underwent a second PPV for recurrent retinal detachment. Two months later, she presented with bilateral panuveitis. Both patients were diagnosed with SO and were treated with methylprednisolone and cyclosporine. The first patient was further treated with a dexamethasone intravitreal implant (Ozurdex®) owing to the side effects of methylprednisolone. The VA and symptoms improved significantly after treatment in both patients. Bilateral granulomatous panuveitis following PPV should alert surgeons to consider SO. Appropriate interventions for SO can produce positive outcomes.

Activatable Optical Probes for Fluorescence and Photoacoustic Imaging of Drug‐Induced Liver Injury

“…[ 5,6 ] The current clinical standard diagnosis of DILI often relies on changes in the conventional liver serum biomarker alanine aminotransferase (ALT). [ 7 ] However, the levels of ALT can be affected by a variety of other diseases, such as muscle injury [ 8 ] or coronary heart disease, [ 9 ] which may increase the risk of false‐positive signals of DILI diagnosis. In addition, only 40% of patients have abnormal ALT levels in the early state of DILI, [ 10 ] indicating that serum testing cannot reflect the changes in liver functions at an early stage.…”