Sympathetic regulation and anterior cingulate cortex volume are altered in a rat model of chronic back pain

Touj, Sara; Houle, Sébastien; Ramla, Djamel; Jeffrey-Gauthier, Renaud; Hotta, Harumi; Bronchti, Gilles; Martinoli, Maria-Grazia; Piché, Mathieu

doi:10.1016/j.neuroscience.2017.03.047

Cited by 12 publications

(16 citation statements)

References 70 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Injection of musculoskeletal tissues with CFA is a common approach to study musculoskeletal pain mechanisms (Ambalavanar et al, 2006;Asgar et al, 2015). When injected in muscles or fascia, a low dose of CFA induces chronic inflammation in a limited area of the injected tissues (Decaris et al, 1999;Touj et al, 2017). In the present study, a low dose of CFA was used to induce chronic back muscle inflammation and local chronic inflammatory changes persisted for at least 2 months.…”

Section: Discussionmentioning

confidence: 82%

“…Chronic back muscle inflammation was induced by intramuscular injection of Complete Freund Adjuvant (CFA; Mycobacterium tuberculosis; 0.15 mg/0.15 ml; Difco Lab. ), as described previously (Touj et al, 2017). Under isoflurane anesthesia (4% inhalation for induction and 2%-2.5% for maintenance), a 27-gauge needle was inserted through the skin into the left T2 paraspinal muscles and kept in place for 3 min after injection of 150 µl of CFA.…”

Section: Chronic Back Pain Modelmentioning

confidence: 99%

“…The aim of this study was to examine the role of the CeA in widespread hypersensitivity to noxious stimuli in a rat model of chronic back pain (Touj et al, 2017). Assessment of mechanical sensitivity and extracellular recordings in the CeA were used to confirm widespread hypersensitivity and altered nociceptive processing.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Attenuation of widespread hypersensitivity to noxious mechanical stimuli by inhibition of GABAergic neurons of the right amygdala in a rat model of chronic back pain

Tokunaga

Takahashi

Touj

et al. 2022

European Journal of Pain

Self Cite

View full text Add to dashboard Cite

Background: Chronic primary low back pain may be associated with hyperalgesia in uninjured tissues and with decreased pain inhibition. Previous studies have shown that the amygdala is involved in pain regulation and chronic pain, that neuronal activity in the amygdala is altered in models of persistent pain, and that the central nucleus of the right amygdala plays an active role in widespread hypersensitivity to noxious stimuli. Methods: Behavioral, electrophysiological, biochemical, and chemogenetic methods were used to examine the role of the central nucleus of the right amygdala in hypersensitivity to noxious stimuli in a rat model of chronic back pain induced by a local injection of Complete Freund Adjuvant (CFA) in paraspinal muscles.Results: CFA produced chronic inflammation limited to the injected area. CFAtreated rats showed increased pain-like (liking) behaviors during the formalin test compared with controls. They also showed widespread mechanical hypersensitivity compared with controls, which persisted for 2 months. This widespread hypersensitivity was accompanied by altered activity of different types of right amygdala neurons, as shown by extracellular recordings. Plasmatic levels of IL-1β, IL-6, and TNF-α were not elevated after 1 or 2 months, indicating that persistent widespread hypersensitivity is not caused by persistent systemic inflammation.However, chemogenetic inhibition of GABAergic neurons in the right amygdala attenuated widespread mechanical hypersensitivity. Conclusions:These findings indicate that chronic widespread mechanical hypersensitivity in a model of chronic back pain can be attenuated by inhibiting GABAergic neurons of the right amygdala, and that widespread hypersensitivity is not maintained by chronic systemic inflammation. Significance:The amygdala is a key structure involved in pain perception and modulation. The present results indicate that the GABAergic neurons of its central nucleus are involved in widespread hypersensitivity to noxious stimuli in a rat model of chronic back pain. The inhibition of amygdala GABAergic neurons

show abstract

Section: Discussionmentioning

confidence: 82%

Section: Chronic Back Pain Modelmentioning

confidence: 99%

See 1 more Smart Citation

Attenuation of widespread hypersensitivity to noxious mechanical stimuli by inhibition of GABAergic neurons of the right amygdala in a rat model of chronic back pain

Tokunaga

Takahashi

Touj

et al. 2022

European Journal of Pain

Self Cite

View full text Add to dashboard Cite

show abstract

“…Anticipatory responses associated with ACC (inc subgenual ACC) have been associated with sympathetic features (for example anxiety in anticipation of pain, (35), reward anticipation (36), but anticipatory responses in general are not exclusively associated with sympathetic activation (forewarned reaction time (37), threat (38)). The evidence suggests ACC and autonomic nervous system have a demonstrable relationship (18, 39–41). Our study found dorsal ACC activity that can be described as being anticipatory for exercise.…”

Section: Discussionmentioning

confidence: 99%

Direct neurophysiological evidence for a role of the human anterior cingulate cortex in central command

Gillies

Huang

Hyam

et al. 2019

Autonomic Neuroscience

View full text Add to dashboard Cite

We provide the first invasive electrophysiological evidence to support the role of the ACC in both motor preparation and the top-down control of cardiovascular function in exercise. This further implicates the ACC in the body's response to the outside world and its possible involvement in such extreme responses as emotional syncope and hyperventilation. In addition we describe the frequency at which the neuronal ACC populations perform these tasks in the human.

show abstract

“…Chronic pain may be related to autonomic disturbances, as previous research has indicated that PI values are associated with improvements in pain after lumbar transforaminal block in patients with chronic lower radiculopathy [23]. In a rat model of chronic back pain, subjects exhibited decreased renal blood flow due to altered sympathetic regulation as well as structural changes in the cingulate cortex, both of which may be related to sympathetic dysregulation [28]. However, acute somatic and/or visceral pain cannot be measured simply based on sympathetic changes during anesthesia.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Intraoperative Perfusion Index for Correlation with Acute Postoperative Pain in Patients Undergoing Laparoscopic Colorectal Cancer Surgery

Kwon

Park

Sim

et al. 2019

JCM

View full text Add to dashboard Cite

Despite technical advancements in the perioperative management of cancer surgery, postoperative pain remains a significant clinical issue. We examined the diagnostic value of the intraoperative perfusion index for predicting acute postoperative pain in patients undergoing laparoscopic colorectal cancer surgery. We retrospectively analyzed data for 105 patients who had undergone laparoscopic colorectal cancer surgery. Patients with pain scores <7 and ≥7 on a 10-point scale upon arrival in the postoperative anesthesia care unit (PACU) were categorized into the N and P groups, respectively. The perfusion index value was extracted prior to intubation, at the start and end of surgery, and after extubation. To minimize individual variance in the absolute value of the perfusion index, we calculated the perfusion index change ratio. A total of 98 patients were examined. Among them, 50 (51.0%) and 48 (49.0%) patients reported pain scores of <7 and ≥7 upon arrival at the PACU, respectively. Fentanyl consumption during the intraoperative and PACU periods was significantly higher in Group P than in Group N (p < 0.001). The perfusion index change ratios did not significantly differ between the groups. The intraoperative perfusion index change ratios do not correlate with acute postoperative pain following laparoscopic colorectal cancer surgery.

show abstract

Sympathetic regulation and anterior cingulate cortex volume are altered in a rat model of chronic back pain

Cited by 12 publications

References 70 publications

Attenuation of widespread hypersensitivity to noxious mechanical stimuli by inhibition of GABAergic neurons of the right amygdala in a rat model of chronic back pain

Attenuation of widespread hypersensitivity to noxious mechanical stimuli by inhibition of GABAergic neurons of the right amygdala in a rat model of chronic back pain

Direct neurophysiological evidence for a role of the human anterior cingulate cortex in central command

Evaluation of the Intraoperative Perfusion Index for Correlation with Acute Postoperative Pain in Patients Undergoing Laparoscopic Colorectal Cancer Surgery

Contact Info

Product

Resources

About