Sympathetic Skin Potentials and Bulbocavernosus Reflex in Patients with Chronic Alcoholism and Impotence

Ertekin, Çumhur; Almis, Sait; Ertekin, Nezihe

doi:10.1159/000117367

Cited by 10 publications

(4 citation statements)

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“…22,23 Although a variety of neurophysiological techniques in diseases involving the pelvic floor are currently used, investigations of small afferent fibers are limited to sympathetic skin reflex by median nerve stimulation and perineal skin recording in traumatic spinal cord injury and sexual dysfunction in multiple sclerosis. [24][25][26] In addition, sympathetic skin reflex by penile stimulation and genital/limb recording has been used for the diagnosis of erectile dysfunctions in alcoholic/diabetic patients and amyloidotic polyneuropathy, [27][28][29] whereas nonconventional neurophysiological studies, such as LEPs, for assessing the involvement of small fibers in pelvic floor disorders are still lacking. 30 The aim of this study was to evaluate the feasibility and reproducibility of LEPs to pudendal area stimulation in healthy subjects and to compare LEPs with hand and foot stimulation.…”

mentioning

confidence: 99%

Laser-Evoked Potentials to Pudendal Stimulation in Healthy Subjects: A Pilot Study

Frasson¹,

Tozzi

Bordignon³

et al. 2020

Journal of Clinical Neurophysiology

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Purpose: Laser-evoked potentials (LEPs) are useful neurophysiological tools for investigating the A-delta sensory peripheral fibers and the central nociceptive pathway. The current investigation aims to obtain normative values of LEPs via pudendal nerve stimulation in healthy adult volunteers.Methods: Laser-evoked potentials were recorded in 16 men and 22 women, 22 to 75 years of age, using neodymium and yttrium and aluminum and perovskite laser bilateral stimulation to the pudendal nerve-supplied skin and the dorsal surface of the hands and feet. We assessed the perceptive threshold, latency, and amplitude of the N1 component and main vertex N2-P2 complex. The relationship between gender, age, height, and site of stimulation was statistically analyzed.Results: Both in men and in women, laser perceptive threshold increased from genitalia to foot and from hand to foot (P # 0.001). N1 and N2-P2 latencies progressively increased from pudendal area to hand to foot (P # 0.008). N1 and N2-P2 complex LEP amplitudes progressively decreased from hand to genitalia to foot (P # 0.04). The latencies of N1 component and N2-P2 complex of LEPs correlated with body height, whereas the amplitude of the N2-P2 complex correlated negatively with age; no correlations were observed between the latencies and amplitudes with gender. Conclusions:This study provides normative data on pudendal LEPs versus hand and foot LEPs. Incorporation of pudendal LEPs into clinical practice could provide a valuable neurophysiological tool for the study of pelvic pain syndromes.

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mentioning

confidence: 99%

Laser-Evoked Potentials to Pudendal Stimulation in Healthy Subjects: A Pilot Study

Frasson¹,

Tozzi

Bordignon³

et al. 2020

Journal of Clinical Neurophysiology

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“…Frequent alcohol misuse is also a risk factor for urinary tract infection [79] and hypogonadism [60]. Approximately 50% of male chronic alcohol misusers have either hypogonadism with reduced semen quality and quantity with (in some) abnormal spermatozoa [80,81]. Impotence also arises (Table II).…”

Section: Genitourinary and Reproductive Disorders Due To Alcohol Misusementioning

confidence: 99%

Alcohol as a toxic and disease‐forming agent: Not just the liver and brain and not every drinker

Srirajaskanthan

Preedy

2007

Journal of Nutritional & Environmental Medicine

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Purpose: Excessive alcohol, defined as beyond the limits suggested by various government and statutory bodies, is damaging. This article aims to show that there may be as many as 120-200 adverse medical conditions and pathologies associated with alcohol misuse. Design and method: This review examines the different organ systems within the body and the effect of alcohol on nutrition, bone, skin, the gastrointestinal tract and skeletal muscle. Results: We identified that nearly all organ systems have the potential to be affected by alcohol or its ensuing metabolite acetaldehyde; as a result, the presence of two or more pathologies or conditions in alcohol misusers is not unusual. However, there are genetic factors that make individuals more susceptible to developing alcoholism and alcohol-related disease. These include genes for acetaldehyde formation and oxidation and possibly some neurotransmitters such as GABA, dopamine and 5-HT. For example, in simple terms, subjects with the dysfunctional ALDH2*2 allele which oxidises acetaldehyde less effectively than those with the ALDH2*1 allele generate high concentrations of acetaldehyde. This acts as a deterrent to alcoholism as acetaldehyde produces nausea and adverse cardiovascular symptoms. At the same time those with the ALDH2*2 allele who do consume alcohol have poorer outcome measures than those with the ALDH2*1 allele, due to the cytotoxic effects of acetaldehyde. Conclusions: Excessive ethanol consumption can lead to development of disease in many different organs, through its direct effect and also its toxic metabolites. However, not all individuals are susceptible and there are likely to be genetic as well as environmental factors that increase individuals' predisposition to develop alcohol related co-morbidity.Abbreviations: ADH: alcohol dehydrogenase, ALDH: aldehyde dehydrogenase, GABA: caminobutyric acid, 5-HT: serotonin

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“…Unfortunately therefore, the test cannot be considered to be sufficiently discriminating to be used as a reliable clinical test. A study which evaluated the value of the SSR recorded from the limbs and genital region in 42 patients with urinary and/or sexual complaints found that abnormalities of the SSR could be detected in those patients with polyneuropathy [ 89]. More had an abnormality of the SSR recorded from the lower limbs than from the genital region, but there were two patients who had normal neurophysiological investigations, i.e.…”

Section: Introductionmentioning

confidence: 99%

“…In men with chronic alcoholism and ED, no difference could be detected in the SSR recorded from the genital region between a patient group and controls. From this it was concluded that the problem was not due to an autonomic peripheral neuropathy [ 89].…”

Section: Introductionmentioning

confidence: 99%

The neurology of male sexual dysfunction and its investigation by clinical neurophysiological methods

Fowler

1998

British Journal of Urology

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Sympathetic Skin Potentials and Bulbocavernosus Reflex in Patients with Chronic Alcoholism and Impotence

Cited by 10 publications

References 0 publications

Laser-Evoked Potentials to Pudendal Stimulation in Healthy Subjects: A Pilot Study

Laser-Evoked Potentials to Pudendal Stimulation in Healthy Subjects: A Pilot Study

Alcohol as a toxic and disease‐forming agent: Not just the liver and brain and not every drinker

The neurology of male sexual dysfunction and its investigation by clinical neurophysiological methods

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