Sympathetic skin response in patients with systemic sclerosis and rheumatoid arthritis

Badry, Reda; Gamal, Rania M.; Hassanien, Manal; Hamed, Mohamed Abd El; Hammam, Nevin; Fawal, Bastawy M. El

doi:10.1186/s41983-018-0044-9

Cited by 8 publications

(10 citation statements)

References 16 publications

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“…compared the SSR in 21 patients with systemic sclerosis (SSc) and 39 patients with RA to SSR in 60 healthy participants. 25 They found increased latency and reduced amplitude in SSc and RA patients. The SSR of SSc patients was significantly prolonged in latency and showed reduced amplitude when compared to RA patients.…”

Section: Discussionmentioning

confidence: 97%

Is There Any Sympathetic Skin Response (SSR) Abnormality in Raynaud Phenomenon?

Emad

Farpour

Ahmed

et al. 2021

Sultan Qaboos Univ Med J

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Objectives: Sympathetic skin response (SSR) is a technique for assessment of the damage of peripheral neuropathies and the disorders of the sympathetic system. This study aimed to evaluate SSR among patients with Raynaud phenomenon (RP). Methods: Between January 1, 2015 and December 30, 2018, about 20 patients with RP and 20 healthy subjects as the control group were recruited from patients referring to the Outpatient Clinics of Shiraz medical University. All the participants were clinically examined, and the SSR was performed using a standard protocol. SSR is abnormal when the latency is prolonged and/or the amplitude reduced. Results: Raynaud's group consisted of 19 women (95 %) and 1 male (5%). 3 patients (15 %) with primary Raynaud's phenomenon (PRP) and 17 patients (85%) with secondary Raynaud's phenomenon (SRP). The control group consisted of 16 women (80%) and 4 males (20%). The mean age of the Raynaud's group and control subjects was 43.1±9 and 36.7±8.6 years, respectively. The SSR to the electrical stimulus was absent in 3 patients (PRP patients). The total median nerve mean latencies in the upper limb were 1.9±0.57 and 1.19±0.52 seconds for the Raynaud's group and control groups, respectively (p <0.001). These findings revealed significantly prolonged SSR latencies in the Raynaud's group, while the mean amplitude showed no significant differences in both groups (p =0.756). Conclusion: Absence or prolonged latency of SSR was associated with the disorders of the unmyelinated axons in the sympathetic system. Our findings suggested the disorders of unmyelinated axons in Raynaud's phenomenon. Keywords: Raynaud Disease; Autonomic Nervous System; Electrodiagnosis; Sympathetic Fibers; Nerve Conduction.

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Section: Discussionmentioning

confidence: 97%

Is There Any Sympathetic Skin Response (SSR) Abnormality in Raynaud Phenomenon?

Emad

Farpour

Ahmed

et al. 2021

Sultan Qaboos Univ Med J

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“…In their study, Badry et al 4 compared palmar SSR in systemic sclerosis and rheumatoid arthritis case groups. Palmar SSR to median nerve stimulation (of systemic sclerosis patients and rheumatoid arthritis patients) showed significantly delayed latency and reduced amplitude in comparison to the control group.…”

Section: Discussionmentioning

confidence: 99%

“…Sympathetic skin response (SSR) is a potential generated by sweat glands in response to a variety of stimulation. 4 This technique records changes in skin conductance after activation of sweat glands in areas of the skin that are rich in eccrine glands (commonly palmar and plantar sites) under the neural control of sympathetic cholinergic fibers. 4 SSR potentials can be recorded in response to various stimuli, for example, electric peripheral nerve stimulation, acoustic stimulation, or magnetic stimulation of nerves or the brain.…”

Section: Introductionmentioning

confidence: 99%

“…4 This technique records changes in skin conductance after activation of sweat glands in areas of the skin that are rich in eccrine glands (commonly palmar and plantar sites) under the neural control of sympathetic cholinergic fibers. 4 SSR potentials can be recorded in response to various stimuli, for example, electric peripheral nerve stimulation, acoustic stimulation, or magnetic stimulation of nerves or the brain. Furthermore, R-R interval variation (RRIV), a measure of the heart rate variability is a simple and reliable test used for the evaluation of parasympathetic nervous system autonomic functions of the heart.…”

Section: Introductionmentioning

confidence: 99%

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Investigation of autonomic dysfunction in primary Raynaud’s phenomenon with sympathetic skin response (SSR), R-R interval variation (RRIV) and composite autonomic symptom score (COMPASS)-31

Sicim¹,

Boyraz²,

Demi̇rdaş³

et al. 2021

NeuroAsia

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Background: In this study, we aimed to investigate the autonomic dysfunction in patients with primary Raynaud’s phenomenon with using sympathetic skin response (SSR) as a neurophysiologic test, R-R interval variation analysis and composite autonomic symptom score (COMPASS)-31 questionnaire. Methods: Palmar SSR to median nerve electrical stimulation was recorded in 38 patients with 36 healthy age and sex-matched control subjects. The SSR was recorded from the palmar surface of both left and right hands for patients and control groups. The amplitudes and latencies formed as a result of electrical stimulation were calculated and compared between the two groups. Additionally, R-R interval variability was examined during normal breathing, deep breathing, standing up and Valsalva maneuver in both groups. Furthermore, we asked to complete the COMPASS-31 questionnaire, a validated tool to assess symptoms of autonomic dysfunction. And by calculating total COMPASS-31 scores, the relationship between the two groups was investigated. Results: The Raynaud’s phenomenon and control groups were similar in age (37.4 ± 11.6 vs. 34.9 ± 13.0 years), had identical gender ratios and similar body mass index (24.5 ± 6.1 vs. 25.7 ± 4.6%). Palmar SSR to median nerve stimulation of RP patients shows significantly delayed latency (1890 ± 146) (p=0.03). And no difference between amplitudes in comparison to the control group. In the patient and control groups, R-R interval measurements were evaluated during rest and deep breathing, standing up and Valsalva maneuver. When the R-R interval measurements of the patient and control groups at rest and deep breathing were compared, there was no statistically significant difference between the groups. In addition, COMPASS-31 questionnaire scoring system was applied to both groups. The mean COMPASS-31 score was higher in patient group (22.8 ± 13.8), than from healthy controls (8.9 ± 7.8) (p=0.02) Conclusions: Autonomic dysfunction plays a role in the etiology of Raynaud’s phenomenon, due to latency prolongation in the sympathetic skin response and significant difference between COMPASS-31 tests, and these tests can be used in the diagnosis stage of this disease.

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“…Patients with more severe GI disease had significantly higher scores across several composite autonomic symptom scale-31 (COMPASS-31) subdomains, including OI and secretomotor dysfunction [87]. Pupillary autonomic dysfunction, including several patients with Adie' tonic pupil [85,[88][89][90], abnormal sympathetic skin response [91][92][93] and bladder dysfunction [94], was described. The pathogenesis of autonomic dysfunction in SSc remains elusive to researchers.…”

Section: Autonomic Dysfunction In Systemic Sclerodermamentioning

confidence: 99%

Ganglionic Acetylcholine Receptor Antibodies and Autonomic Dysfunction in Autoimmune Rheumatic Diseases

Imamura

Mukaino

Takamatsu

et al. 2020

IJMS

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Autonomic neuropathy has been reported in autoimmune rheumatic diseases (ARD) including Sjögren’s syndrome, systemic sclerosis, rheumatoid arthritis, and systemic lupus erythematosus. However, the pathophysiological mechanism underlying autonomic dysfunction remains unknown to researchers. On the other hand, autoimmune autonomic ganglionopathy (AAG) is an acquired immune-mediated disorder, which causes dysautonomia that is mediated by autoantibodies against ganglionic acetylcholine receptors (gAChRs). The purpose of this review was to describe the characteristics of autonomic disturbance through previous case reports and the functional tests used in these studies and address the importance of anti-gAChR antibodies. We have established luciferase immunoprecipitation systems to detect antibodies against gAChR in the past and determined the prevalence of gAChR antibodies in various autoimmune diseases including AAG and rheumatic diseases. Autonomic dysfunction, which affects lower parasympathetic and higher sympathetic activity, is usually observed in ARD. The anti-gAChR antibodies may play a crucial role in autonomic dysfunction observed in ARD. Further studies are necessary to determine whether anti-gAChR antibody levels are correlated with the severity of autonomic dysfunction in ARD.

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Sympathetic skin response in patients with systemic sclerosis and rheumatoid arthritis

Cited by 8 publications

References 16 publications

Is There Any Sympathetic Skin Response (SSR) Abnormality in Raynaud Phenomenon?

Is There Any Sympathetic Skin Response (SSR) Abnormality in Raynaud Phenomenon?

Investigation of autonomic dysfunction in primary Raynaud’s phenomenon with sympathetic skin response (SSR), R-R interval variation (RRIV) and composite autonomic symptom score (COMPASS)-31

Ganglionic Acetylcholine Receptor Antibodies and Autonomic Dysfunction in Autoimmune Rheumatic Diseases

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