“…In some studies sucralfate has been found to counteract the negative effects of smoking (for a meta-analysis, see ref 6), the mechanisms G. Lindell Department of Surgery, Lnnd University Hospital, S-22185 Lund, Sweden H. Graffner Helsingborg Hospital, Helsingborg, Sweden being unknown. In an earlier study we showed that nicotine was accumulated in very high concentrations in gastric juice [7] and animal experiments, in which nicotine has been given orally, have demonstrated harmful effects on mucosal cytoprotective properties, such as thickness and quality of mucus [8 10], and local blood flow [11,12].…”