1986
DOI: 10.1016/0014-2999(86)90435-8
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Sympatho-adrenal system involved in the inhibitory effects of nicotine on the vagally stimulated gastric acid output and mucosal blood flow in rats

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Cited by 15 publications
(4 citation statements)
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“…(50 ug/kg per min, for 30 min; 9.25 icmole/kg) inhibits acid output by peripheral activation of the sympatho adrenomedullary system in cases of stimula tion of the vagus nerve (8). In the present study, intravenous administration of this alkaloid (600 nmole/animal) has no inhibi tory effect on the gastric acid output (Fig.1 B).…”
supporting
confidence: 39%
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“…(50 ug/kg per min, for 30 min; 9.25 icmole/kg) inhibits acid output by peripheral activation of the sympatho adrenomedullary system in cases of stimula tion of the vagus nerve (8). In the present study, intravenous administration of this alkaloid (600 nmole/animal) has no inhibi tory effect on the gastric acid output (Fig.1 B).…”
supporting
confidence: 39%
“…After stabilization of the basal acid output, gastric acid output was stimulated by continuous electrode stimulation of the left vagus nerve, the stimulus parameters being square-wave pulses of 0.5 msec duration, at 3 Hz, supar maximal intensity (0.5 mA). These con ditions were the same as previously reported (7,8). Gastric acid output was determined by titration with 0.01 N NaOH and expressed as utEq/15 min, as shown in previous papers (7,8).…”
mentioning
confidence: 83%
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“…In some studies sucralfate has been found to counteract the negative effects of smoking (for a meta-analysis, see ref 6), the mechanisms G. Lindell Department of Surgery, Lnnd University Hospital, S-22185 Lund, Sweden H. Graffner Helsingborg Hospital, Helsingborg, Sweden being unknown. In an earlier study we showed that nicotine was accumulated in very high concentrations in gastric juice [7] and animal experiments, in which nicotine has been given orally, have demonstrated harmful effects on mucosal cytoprotective properties, such as thickness and quality of mucus [8 10], and local blood flow [11,12].…”
Section: Introductionmentioning
confidence: 99%