Sympatho-Inhibitory and Hypotensive Effect of Adrenomedulun Through the Central Nervous System in Salt-Sensitive Hypertension

Fujita, Maho; Kuwaki, Tomoyuki; Shimosawa, Tatsuo; Fujita, Kentaro

doi:10.1097/00004872-200402001-00265

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“…Intracerebroventricular injection of adenoviral vector encoding SOD decreased significantly sympathetic overactivity after myocardial infarction in mice [32]. In fact, we have suggested that ROS may contribute to central sympathetic activation with salt loading in AM knockout mice, model animals with oxidative stress [33]. Thus, oxidative stress may contribute to the sympathetic overactivity in salt-sensitive hypertension, too.…”

Section: Sympathetic Overactivity Due To Oxidative Stressmentioning

confidence: 91%

Role of Salt and Potassium in Hypertension and the Associated Organ Damages

Fujita¹

2005

CHYR

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Excessive salt intake is well-known to be one of the major environmental factor not only to develop human hypertension but also to induce cardiovascular damages. On the other hand, dietary potassium supplementation exerts both anti-hypertensive and cardiovascular protective effects in salt-induced hypertension. In the earlier studies including us, it was suggested that the anti-hypertensive mechanism of dietary potassium is natriuresis and sympatho-inhibitory action. Recently, it has been clarified that salt loading increases production of reactive oxygen species (ROS) in saltsensitive hypertension model animals. Because ROS overproduction induces several disadvantages, such as insulin resistance, the peripheral and central sympathetic overactivity, and an enhanced oxidized low density lipoprotein (LDL) receptor-1, lectin-like oxidized LDL receptor (LOX-1) expression, antioxidants may prevent salt-induced hypertension and cardiovascular damages. Interestingly, some investigators have demonstrated that potassium has antioxidant effect. Indeed, dietary potassium supplementation ameliorates insulin resistance, sympathetic overactivity and LOX-1 upregulation associated with decrement of ROS production. Thus, opposite actions between salt and potassium on ROS production may play an important role of their influences on blood pressure and cardiovascular effects.

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Section: Sympathetic Overactivity Due To Oxidative Stressmentioning

confidence: 91%

Role of Salt and Potassium in Hypertension and the Associated Organ Damages

Fujita¹

2005

CHYR

View full text Add to dashboard Cite

show abstract

Sympatho-Inhibitory and Hypotensive Effect of Adrenomedulun Through the Central Nervous System in Salt-Sensitive Hypertension

Cited by 1 publication

References 0 publications

Role of Salt and Potassium in Hypertension and the Associated Organ Damages

Role of Salt and Potassium in Hypertension and the Associated Organ Damages

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