The Lung Circulation 1965
DOI: 10.1016/b978-0-08-010988-6.50017-2
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Sympathomimetic Drugs

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Cited by 11 publications
(10 citation statements)
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“…These effects were dose-dependent and were not followed at any dose level in any experiment by secondary rises in hepatic arterial blood flow, which would indicate hepatic arterial vasodilatation. It is established that phenylephrine produces vasoconstriction in other vascular beds by direct a-adrenoceptor stimulation, and is devoid of actions on cardiac and other /3-adrenoceptors (Aviado, 1959;1970;Innes & Nickerson, 1975): on these grounds, it is commonly used as a pure a-adrenoceptor stimulant in the analysis and definition of adrenoceptor populations in vascular and non-vascular tissues. In the present experiments the specificity of phenylephrine as an aadrenoceptor agonist was confirmed by the lack of antagonism by propranolol: a dose of propranolol sufficient to cause a shift of the isoprenaline doseresponse curve on the hepatic arterial vasculature to the right, was without any effect on the form or position of the phenylephrine dose-response curve in this vascular bed.…”
Section: Discussionmentioning
confidence: 99%
“…These effects were dose-dependent and were not followed at any dose level in any experiment by secondary rises in hepatic arterial blood flow, which would indicate hepatic arterial vasodilatation. It is established that phenylephrine produces vasoconstriction in other vascular beds by direct a-adrenoceptor stimulation, and is devoid of actions on cardiac and other /3-adrenoceptors (Aviado, 1959;1970;Innes & Nickerson, 1975): on these grounds, it is commonly used as a pure a-adrenoceptor stimulant in the analysis and definition of adrenoceptor populations in vascular and non-vascular tissues. In the present experiments the specificity of phenylephrine as an aadrenoceptor agonist was confirmed by the lack of antagonism by propranolol: a dose of propranolol sufficient to cause a shift of the isoprenaline doseresponse curve on the hepatic arterial vasculature to the right, was without any effect on the form or position of the phenylephrine dose-response curve in this vascular bed.…”
Section: Discussionmentioning
confidence: 99%
“…the possibility that 6-OHDA might have a postsynaptic effect was explored. Methoxamine is a pure alpha-adrenoceptor ago nist (Aviado, 1970) and is not a substrate for neuronal uptake (Trendelenburge\. al., 1970).…”
Section: Discussionmentioning
confidence: 99%
“…Phenylpropanolamine, an analog of amphetamine, was reported to induce moderate anorexia and weight loss in rodents and humans but was without the properties of arousal and dependence that are characteristic of the amphetamines (Aviado, 1970; Epstein, 1959; Griboff, Berman, & Silverman, 1975;Kornblith & Hoebel, 1976). It is precisely because of these properties (and lack thereof) that over-the-counter weight loss preparations containing PP A have enjoyed considerable commercial success.…”
mentioning
confidence: 99%
“…Comparison of the dose-response curves for the aversion and hypodipsia induced by PPA indicates that a single process, presumably malaise or toxicosis, may mediate these effects. These findings question the notion that PPA induces anorexia via activation of a CNS satiety mechanism and lend credence to the suggestion advanced herein that nonspecific malaise may mediate the moderate anorectic activity of PPA observed in rodents and humans.Of the numerous drugs ascribed anorectic properties over the past four decades (Aviado, 1970; Costa & Garratini, 1970), phenylpropanolamine (PPA) has perhaps held the greatest promise as a weight control substance for obese humans. Phenylpropanolamine, an analog of amphetamine, was reported to induce moderate anorexia and weight loss in rodents and humans but was without the properties of arousal and dependence that are characteristic of the amphetamines (Aviado, 1970;Epstein, 1959;Griboff, Berman, & Silverman, 1975;Kornblith & Hoebel, 1976).…”
mentioning
confidence: 99%
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