Abstract. Suppose that C = (C 1 , . . . , Cm) is a configuration of 2-dimensional symplectic submanifolds in a symplectic 4-manifold (X, ω) with connected, negative definite intersection graph Γ C . We show that by replacing an appropriate neighborhood of ∪C i with a smoothing W S of a normal surface singularity (S, 0) with resolution graph Γ C , the resulting 4-manifold admits a symplectic structure. This operation generalizes the rational blow-down operation of Fintushel-Stern for other configurations, and therefore extends Symington's result about symplectic rational blow-downs.