Symposium: Binding of upids by proteins conducted Ly The American Oil Chemists舗 Society at its 37tn pall meeting, Minneapolis, Minnesota September 30舑Octoter 2, 1963

Therriault, D. H.; Wheeler, D. H.; Program,

doi:10.1007/bf02670028

Cited by 33 publications

(1 citation statement)

References 28 publications

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“…Saliva has been proven to have high correlation values to cortisol levels in blood with a non-invasive in situ collection method, so it is more lucrative for cortisol determination compared with blood [ 16 , 17 ]. In clinical practice, about 80% of the cortisol in the blood is combined with cortieosteroid-binding globulin (CBG), and the rest is in a free state [ 18 ]. It is only the free fraction that is biologically active and can activate signaling pathways via glucocorticoid hormone receptors in cells [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Stimulated Parotid Saliva Is a Better Method for Depression Prediction

et al. 2022

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Background: Saliva cortisol is considered to be a biomarker of depression prediction. However, saliva collection methods can affect the saliva cortisol level. Objective: This study aims to determine the ideal saliva collection method and explore the application value of saliva cortisol in depression prediction. Methods: 30 depressed patients and 30 healthy controls were instructed to collect saliva samples in the morning with six collection methods. Simultaneous venous blood was collected. Enzyme-linked immunosorbent assay was used to determine the cortisol level. The 24-observerrated Hamilton depression rating scale (HAMD-24) was used to assess the severity of depression. Results: The significant differences in saliva cortisol levels depend on the saliva collection methods. The level of unstimulated whole saliva cortisol was most correlated with blood (r = 0.91). The stimulated parotid saliva cortisol can better predict depression. The area under the curve was 0.89. In addition, the saliva cortisol level of the depression patients was significantly higher than the healthy controls. The correlation between the cortisol level and the HAMD-24 score was highly significant. The higher the saliva cortisol level, the higher the HAMD-24 score. Conclusions: All the above findings point to an exciting opportunity for non-invasive monitoring of cortisol through saliva.

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Section: Introductionmentioning

confidence: 99%

Stimulated Parotid Saliva Is a Better Method for Depression Prediction

et al. 2022

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Anti‐Inflammatory Steroids

Avery

Woolfrey

2003

Burger's Medicinal Chemistry and Drug Discovery

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We know today that structural changes in steroids can bring about potency alterations in animal pharmacology through a number of mechanisms. The processes that are affected include pharmacokinetic parameters such as drug absorption and drug distribution, as well as drug metabolism to more or less active metabolites. There is now a large body of literature dealing with these phenomena that makes predictive thinking possible in these areas. Other mechanisms that are involved in the effect of structural changes on pharmacological activity in steroids include the effect of steroid structure on receptor affinity and the manner in which changes in the steroid agonist affect intrinsic activity through alterations in gene expression. These and other concepts relating to anti‐inflammatory steroids are discussed in this chapter.

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Anti‐Inflammatory Glucocorticoids

Avery

Chittiboyina

2010

Burger's Medicinal Chemistry and Drug Discovery

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Glucocorticoids are the first line medication used in the treatment of afflictions ranging from the moderate skin rash to severe acute inflammatory disorders. They exert their activity through binding to the glucocorticoid receptor, a ligand‐dependent transcription factor, and result in either activation or repression of a large set of glucocorticoid responsive genes. The glucocorticoid receptor ( GR ) is a cytoplasmic protein of complex structure that is associated with various heat shock proteins (e.g., hsp 90). The desired immunosuppressive effect is apparently due largely to the downregulation of a variety of proinflammatory factors, whereas adverse reactions such as corticoid‐induced diabetes and osteoporosis could be connected to the inappropriate activation of genes involved in the control of metabolic processes. The discovery of selective receptor modulators, which maintain beneficial therapeutic activity together with a diminished risk of side effects, focuses on ligands that lead to repression rather than activation of genes targeted by the glucocorticoid receptor. Current drug‐screening programs have yielded a number of molecules including steroidal as well as nonsteroidal compounds, which preferentially induce receptor‐mediated repression.

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Symposium: Binding of upids by proteins conducted Ly The American Oil Chemists舗 Society at its 37tn pall meeting, Minneapolis, Minnesota September 30舑Octoter 2, 1963

Cited by 33 publications

References 28 publications

Stimulated Parotid Saliva Is a Better Method for Depression Prediction

Stimulated Parotid Saliva Is a Better Method for Depression Prediction

Anti‐Inflammatory Steroids

Anti‐Inflammatory Glucocorticoids

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