2018
DOI: 10.3168/jds.2017-13340
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Symposium review: Modulating adipose tissue lipolysis and remodeling to improve immune function during the transition period and early lactation of dairy cows

Abstract: Despite major advances in our understanding of transition and early lactation cow physiology and the use of advanced dietary, medical, and management tools, at least half of early lactation cows are reported to develop disease and over half of cow deaths occur during the first week of lactation. Excessive lipolysis, usually measured as plasma concentrations of free fatty acids (FFA), is a major risk factor for the development of displaced abomasum, ketosis, fatty liver, and metritis, and may also lead to poor … Show more

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Cited by 66 publications
(53 citation statements)
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References 156 publications
(187 reference statements)
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“…A certain level of FFA is considered normal and necessary. However, FFA concentrations increase when lipolysis is excessive; this is associated with a detrimental effect on immunity, metabolism, and milk production (Roche et al, 2013;Contreras et al, 2018). Part of the circulating FFA are converted into ketone Clusters were created using the k-means clustering method based on the log-transformed and standardized concentrations of glucose, IGF-I, FFA, and BHB.…”
Section: Discussionmentioning
confidence: 99%
“…A certain level of FFA is considered normal and necessary. However, FFA concentrations increase when lipolysis is excessive; this is associated with a detrimental effect on immunity, metabolism, and milk production (Roche et al, 2013;Contreras et al, 2018). Part of the circulating FFA are converted into ketone Clusters were created using the k-means clustering method based on the log-transformed and standardized concentrations of glucose, IGF-I, FFA, and BHB.…”
Section: Discussionmentioning
confidence: 99%
“…An additional factor that might confound the results of the present study is the fact that mRNA expression was determined at the level of the adipose tissue. This comprises the mRNA expression of all the cells that reside within the adipose tissue, including preadipocytes, fibroblasts, endothelial cells, mast cells, dendritic cells, neutrophils, eosinophils, basophils, lymphocytes, and macrophages (Heilbronn and Campbell, 2008;Contreras et al, 2018). Based on the results of the present study, it is not possible to identify the cellular source of the different adipokines.…”
Section: Influence Of Adipocyte Size and Adipose Depot On Atmmentioning
confidence: 82%
“…Postpartum uterine disease has long-term effects on the subsequent establishment of pregnancy (Carneiro et al, 2016;Ribeiro et al, 2016). The inability of the cow to resolve uterine disease may be explained in part by immune dysfunction early postpartum that is caused by a metabolic profile that antagonizes the innate immune system (Contreras et al, 2018;Sheldon et al, 2018).…”
Section: Uterine Involutionmentioning
confidence: 99%
“…The cow's immune system is primarily responsible for resolution of disease and recovery from inflammation within the uterus postpartum (Contreras et al, 2018;Sheldon et al, 2018). The low circulating glucose and elevated circulating BHB that are found during early lactation can antagonize circulating immune cell function (Lucy et al, 2014).…”
Section: Uterine Healthmentioning
confidence: 99%