Symptom Burden in Patients With Reduced Performance Status at the Start of Palliative Radiotherapy

Nieder, Carsten; Kämpe, Thomas A

doi:10.21873/invivo.11832

Cited by 6 publications

(6 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous findings on marital status were inconsistent; some were non-significant findings while some found that widowed older adults were less likely to go to medicalized settings at the end of life. 32,33 We found that people who were divorced with children or single or never married were more likely to prefer receiving palliative care at home than those married with children. It could be the reason that Chinese people with intact families tend to feel more connected to their families, regardless of the physical location of home; in contrast, those who were not married or divorced might need to be physically at home to feel the sense of being safe and belonged.…”

Section: Discussionmentioning

confidence: 79%

Do People Prefer Home Palliative Care? A Survey Study and Assessment of Associated Factors in China

Tong,

Wang,

Cao

2024

J Palliat Care

View full text Add to dashboard Cite

Objectives: This study examined people's preference for the location to receive palliative care services and determined the associated factors. Methods: A questionnaire with reference to the Chinese version of the Hospice Attitude Scale and the Death Correspondence Scale was designed, piloted, revised, and distributed online and in person to collect data (N = 762). Binary logistic regression was used to analyze the effects of relevant factors. Results: The average age of the participants was 38.1, with a relatively even gender distribution. Over 90% of the participants were either single/never married (44.9%) or married with children (46.0%). 58.1% of the respondents (N = 428) indicated that they would like to receive palliative care at home, compared to 41.9% who preferred receiving such care in institutions or other places (N = 309). Each time people's attitudes toward death became one point more positive, they were 10.2% more likely to choose to receive palliative care services at home. People with a neutral attitude toward palliative care, single/never married or divorced with children, and having/had an occupation in health and social work had higher odds of preferring receiving palliative care at home. Those who had poor self-rated health or with an educational background of primary school or lower or some college had lower odds of preferring receiving palliative care at home. Conclusions: The research showed that attitudes toward death and other factors were associated with people's preferences for palliative care locations. More accessible and affordable community-based and home-based palliative care services should be further explored and provided.

show abstract

Section: Discussionmentioning

confidence: 79%

Do People Prefer Home Palliative Care? A Survey Study and Assessment of Associated Factors in China

Tong,

Wang,

Cao

2024

J Palliat Care

View full text Add to dashboard Cite

show abstract

“…Multiple prior analyses have demonstrated a relationship between PROs and survival outcomes in several different cancer populations 2,9,30‐32 . In the baseline setting, these findings may be attributed to a higher symptom burden at the initiation of systemic chemotherapy correlating with a lower performance status, a metric also previously shown to correlate with overall survival 33,34 . Patients with reduced performance status and/or higher symptom burden may be less able to tolerate therapy, thus attenuating the ability of cancer treatment to offer survival benefits 35 .…”

Section: Discussionmentioning

confidence: 99%

“…2,9,[30][31][32] In the baseline setting, these findings may be attributed to a higher symptom burden at the initiation of systemic chemotherapy correlating with a lower performance status, a metric also previously shown to correlate with overall survival. 33,34 Patients with reduced performance status and/or higher symptom burden may be less able to tolerate therapy, thus attenuating the ability of cancer treatment to offer survival benefits. 35 In addition, we found that baseline PROs are associated with unplanned hospitalizations.…”

Section: Discussionmentioning

confidence: 99%

Associations of baseline patient‐reported outcomes with treatment outcomes in advanced gastrointestinal cancer

Seventer

Fish

Fosbenner

et al. 2020

Cancer

View full text Add to dashboard Cite

Background Patient‐reported outcomes (PROs) assessing quality of life (QOL) and symptom burden correlate with clinical outcomes in patients with cancer. However, to the authors' knowledge, data regarding associations between PROs and treatment response are lacking. Methods The authors prospectively approached consecutive patients with advanced gastrointestinal cancer who were initiating a new treatment. Prior to treatment, patients reported their QOL (Functional Assessment of Cancer Therapy‐General [FACT‐G], 4 subscales: Functional, Physical, Emotional, Social; higher scores indicate better QOL) and symptom burden (Edmonton Symptom Assessment System [ESAS], Patient Health Questionnaire‐4 [PHQ‐4]; higher scores represent greater symptoms). Regression models were used to examine associations of baseline PROs with treatment response (clinical benefit or progressive disease [PD] at time of first scan), healthcare utilization, and survival. Results From May 2019 to April 2020, a total of 112 patients with advanced gastrointestinal cancer were enrolled. For treatment response, 64.3% had CB and 35.7% had PD. Higher baseline ESAS‐Physical (odds ratio, 1.04; P = .027) and lower FACT‐G Functional (odds ratio, 0.92; P = .038) scores were associated with PD. Higher ESAS‐Physical (hazard ratio [HR], 1.03; P = .044) and lower FACT‐G Total (HR, 0.96; P = .005), FACT‐G Physical (HR, 0.89; P < .001), and FACT‐G Functional (HR, 0.87; P < .001) scores were associated with a greater hospitalization risk. Lower FACT‐G Total (HR, 0.96; P = .009) and FACT‐G Emotional (HR, 0.86; P = .012) scores as well as higher ESAS‐Total (HR, 1.03; P = .014) and ESAS‐Physical (HR, 1.04; P = .032) scores were associated with worse survival. Conclusions Baseline PROs are associated with treatment response in patients with advanced gastrointestinal cancer, namely physical symptoms and functional QOL, in addition to health care use and survival. The findings of the current study support the association between PROs and important clinical outcomes, including the novel finding of treatment response.

show abstract

“…However, the balance between providing symptomatic relief and ensuring patient safety remains a critical concern. Patients with a limited life expectancy and a compromised performance status might not derive a net advantage from undergoing palliative radiotherapy (9). There is a pressing need for endeavors directed towards the improvement and precision of the criteria employed for determining the appropriate timing of radiotherapy initiation (10).…”

Section: Discussionmentioning

confidence: 99%

Thirty-day Mortality in Palliative Radiotherapy: A Retrospective Cohort Analysis in a Single Center

KATANO,

TONGYU,

MINAMITANI

et al. 2023

CDP

View full text Add to dashboard Cite

Background/Aim: Palliative radiotherapy is a critical component of cancer care aimed at symptom management and enhancing the quality of life of patients with advanced cancer. Balancing symptom relief and potential risks is pivotal in clinical decision-making. This study explored the 30-day mortality (30-DM) rate after palliative radiotherapy in a single-center setting to shed light on potential prognostic factors and safety considerations. Patients and Methods: This retrospective cohort study included patients who underwent palliative radiotherapy for various indications between March 2020 and February 2023. Data were retrieved from electronic medical records and analyzed according to ethical guidelines. The primary outcome measure was 30-DM rate, and multivariate logistic regression analysis was conducted to identify the independent predictors of 30-DM. Results: A total of 931 palliative radiotherapy sessions were administered to 601 patients, with a median of one session per patient. The cohort had a median age of 70 years, predominantly men (58%), and featured diverse primary cancer types, with lung cancer being the most prevalent (15.8%). The 30-DM rate was 12.9%. Multivariate analysis identified Karnofsky Performance Status (KPS) as the sole independent prognostic factor significantly associated with 30-DM. Conclusion: This study provides valuable insights into 30-DM rates following palliative radiotherapy. Future research should focus on prospective multicenter investigations with larger cohorts and comprehensive data collection, ultimately leading to improved risk prediction models for personalized treatment decisions in palliative radiotherapy.

show abstract

Symptom Burden in Patients With Reduced Performance Status at the Start of Palliative Radiotherapy

Cited by 6 publications

References 20 publications

Do People Prefer Home Palliative Care? A Survey Study and Assessment of Associated Factors in China

Do People Prefer Home Palliative Care? A Survey Study and Assessment of Associated Factors in China

Associations of baseline patient‐reported outcomes with treatment outcomes in advanced gastrointestinal cancer

Thirty-day Mortality in Palliative Radiotherapy: A Retrospective Cohort Analysis in a Single Center

Contact Info

Product

Resources

About