Symptom burden in stable COPD patients with moderate or severe airflow limitation

Eckerblad, Jeanette; Tödt, Kristina; Jakobsson, Per; Unosson, Mitra; Skargren, Elisabeth; Kentsson, Magnus; Theander, Kersti

doi:10.1016/j.hrtlng.2014.04.004

Cited by 49 publications

(49 citation statements)

References 51 publications

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“…While instruments like the Memorial Symptom Assessment Scale have been used to assess symptoms in patients with heart failure (68-70), COPD (71,72), and HIV disease (11,73), the most valid and reliable instrument to assess symptoms for symptom cluster research across a variety of chronic conditions is yet to be developed.…”

Section: Transferability To Other Chronic Conditionsmentioning

confidence: 99%

Advancing Symptom Science Through Symptom Cluster Research: Expert Panel Proceedings and Recommendations

Miaskowski

Barsevick

Berger

et al. 2017

JNCI J Natl Cancer Inst

338

330

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An overview of proceedings, findings, and recommendations from the workshop on "Advancing Symptom Science Through Symptom Cluster Research" sponsored by the National Institute of Nursing Research (NINR) and the Office of Rare Diseases Research, National Center for Advancing Translational Sciences, is presented. This workshop engaged an expert panel in an evidenced-based discussion regarding the state of the science of symptom clusters in chronic conditions including cancer and other rare diseases. An interdisciplinary working group from the extramural research community representing nursing, medicine, oncology, psychology, and bioinformatics was convened at the National Institutes of Health. Based on expertise, members were divided into teams to address key areas: defining characteristics of symptom clusters, priority symptom clusters and underlying mechanisms, measurement issues, targeted interventions, and new analytic strategies. For each area, the evidence was synthesized, limitations and gaps identified, and recommendations for future research delineated. The majority of findings in each area were from studies of oncology patients. However, increasing evidence suggests that symptom clusters occur in patients with other chronic conditions (eg, pulmonary, cardiac, and end-stage renal disease). Nonetheless, symptom cluster research is extremely limited and scientists are just beginning to understand how to investigate symptom clusters by developing frameworks and new methods and approaches. With a focus on personalized care, an understanding of individual susceptibility to symptoms and whether a "driving" symptom exists that triggers other symptoms in the cluster is needed. Also, research aimed at identifying the mechanisms that underlie symptom clusters is essential to developing targeted interventions.Patients with chronic conditions, such as cancer and other rare diseases, experience an array of multiple co-occurring symptoms (eg, pain, fatigue, sleep disturbance). When these symptoms remain underdiagnosed and undertreated, they have a negative impact on patient-reported outcomes (PROs) including functional performance, cognitive status, and quality of life (QOL). A reduction in symptom burden in these patients has the potential to improve their capacity to live well over their entire lives. To achieve this goal, a transformation is needed in how multiple co-occurring symptoms are assessed and managed in order to improve patient outcomes and stimulate a reduction in health care utilization and costs. A strategic plan that advances REVIEW

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Section: Transferability To Other Chronic Conditionsmentioning

confidence: 99%

Advancing Symptom Science Through Symptom Cluster Research: Expert Panel Proceedings and Recommendations

Miaskowski

Barsevick

Berger

et al. 2017

JNCI J Natl Cancer Inst

338

330

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“…106 Patients rank cough as the second most prevalent symptom. Chronic cough with sputum production is common and is often considered to be the first symptom of COPD.…”

Section: Cancermentioning

confidence: 99%

Management of chronic refractory cough

Gibson

Vertigan

2015

BMJ

110

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Chronic refractory cough (CRC) is defined as a cough that persists despite guideline based treatment. It is seen in 20-46% of patients presenting to specialist cough clinics and it has a substantial impact on quality of life and healthcare utilization. Several terms have been used to describe this condition, including the recently introduced term cough hypersensitivity syndrome. Key symptoms include a dry irritated cough localized around the laryngeal region. Symptoms are not restricted to cough and can include globus, dyspnea, and dysphonia. Chronic refractory cough has factors in common with laryngeal hypersensitivity syndromes and chronic pain syndromes, and these similarities help to shed light on the pathophysiology of the condition. Its pathophysiology is complex and includes cough reflex sensitivity, central sensitization, peripheral sensitization, and paradoxical vocal fold movement. Chronic refractory cough often occurs after a viral infection. The diagnosis is made once the main diseases that cause chronic cough have been excluded (or treated) and cough remains refractory to medical treatment. Several treatments have been developed over the past decade. These include speech pathology interventions using techniques adapted from the treatment of hyperfunctional voice disorders, as well as the use of centrally acting neuromodulators such as gabapentin and pregabalin. Potential new treatments in development also show promise.

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“…This study is part of a cross‐sectional study designed to examine symptoms, function and health in patients with stable COPD . Eligible subjects were all patients that had visited the outpatient clinic in one university hospital and one county hospital in Sweden.…”

Section: Methodsmentioning

confidence: 99%

Factors associated with low physical activity in patients with chronic obstructive pulmonary disease: a cross‐sectional study

Tödt

Skargren

Jakobsson

et al. 2015

Scandinavian Caring Sciences

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Symptom burden in stable COPD patients with moderate or severe airflow limitation

Cited by 49 publications

References 51 publications

Advancing Symptom Science Through Symptom Cluster Research: Expert Panel Proceedings and Recommendations

Advancing Symptom Science Through Symptom Cluster Research: Expert Panel Proceedings and Recommendations

Management of chronic refractory cough

Factors associated with low physical activity in patients with chronic obstructive pulmonary disease: a cross‐sectional study

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