Symptom Clusters and Quality of Life in Gastric Cancer Patients Receiving Chemotherapy

Fu, Liang; Feng, Xiuqin; Jin, Yujia; Lu, Zhenqi; Li, Rufang; Xu, Wenxia; Chang, Victor; Hu, Yan; Ye, Xianghong

doi:10.1016/j.jpainsymman.2021.09.003

Cited by 38 publications

(17 citation statements)

References 47 publications

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“…The present study demonstrate that in patients with MG, the major contributor to the poorer QOL in MG patients is the direct effect from SC, that is, the higher the SC score, the worse the QOL, which is consistent with previous findings by Al et al (2021) and Fu et al (2022). For instance, patients with pure ocular symptoms have little effect on their QOL.…”

Section: Discussionsupporting

confidence: 93%

Effects of symptom clusters on quality of life mediated by self‐efficacy among individuals with myasthenia gravis: A structural equation modelling analysis

Song

Huang

2022

Journal of Clinical Nursing

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Aims and Objectives: To determine whether self-efficacy mediates the relationship between Symptom Clusters (SC) and quality of life (QOL) in patients with myasthenia gravis (MG). Background:The QOL in patients with MG can be affected not only by the SC but the self-efficacy in previous studies, while the latter may also be contributed by the former. However, it is still unclear whether self-efficacy mediates the relationship between SC and QOL in patients with MG.Design: A cross-sectional survey was conducted in patients with MG who were recruited from our institution from October 2021 to March 2022, which was reported in line with the STROBE guidelines. Methods:The hypothetical model was tested and all the effects of SC and self-efficacy on QOL were estimated based on structural equation modelling (SEM) analysis after conducting a confirmatory factor analysis of the scales in a separate cohort.Results: Three scales for symptoms (four summated items), self-efficacy (four plus one parcelled item) and MG-QOL (three summated items) were validated according to the confirmatory factor analysis in 72 patients. An SEM analysis of another 310 participants revealed that SC exerted significant direct effects on QOL and self-efficacy, with values of .585 and −.293, respectively, and self-efficacy also had a significant effect on QOL (−.141). The indirect effect of SC on QOL via self-efficacy was .041, accounting for 6.6% of the overall effect. Male and female patients did not differ in the direct and indirect effects of symptoms on QOL. Conclusions:This study suggests that, although self-efficacy partially mediates the relationship between SC and QOL in patients with MG, worsening of symptoms remains the leading contributor to the decreased QOL. Relevance to Clinical Practice:These results may provide a potential clue for doctors, nurses, and other caregivers to optimise treatment strategies for targeted patients with MG.

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Section: Discussionsupporting

confidence: 93%

Effects of symptom clusters on quality of life mediated by self‐efficacy among individuals with myasthenia gravis: A structural equation modelling analysis

Song

Huang

2022

Journal of Clinical Nursing

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“…In addition, the effects of sociodemographic and clinical variables on QoL were controlled in our final model. The results of this study revealed that monthly income appeared to positively correlated with QoL, which echoes the previous study (4,59). The possible explanation is that the choice of treatment modalities was affected by the economic status of the patients, resulting in differences in health outcomes and QoL.…”

Section: Discussionsupporting

confidence: 79%

Symptom Clusters and Quality of Life in Cervical Cancer Patients Receiving Concurrent Chemoradiotherapy: The Mediating Role of Illness Perceptions

et al. 2022

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ObjectivesAlthough studies shows that symptom clusters and illness perceptions are negatively associated with quality of life (QoL), it is unclear how these variables of cervical cancer patients who receive concurrent chemoradiotherapy (CCRT) relate to each other. This study aimed to identify the symptom clusters in cervical cancer patients who receive CCRT and evaluate the mediating effect of illness perceptions on the relationship between symptom clusters and QoL.MethodsA cross-sectional survey was conducted on 286 cervical cancer patients receiving CCRT from October 2019 to October 2020. M.D. Anderson Symptom Inventory, Brief Illness Perception Questionnaire, and Functional Assessment Cancer Therapy-Cervix were applied to investigate the symptom clusters, illness perceptions and QoL of the participants, respectively. Exploratory factor analysis was conducted to identify symptom clusters. The relationships among symptom clusters, illness perceptions, and QoL were analyzed with the structural equation modeling.ResultsA total of four symptom clusters were identified, including psychological status symptom cluster, therapy side-effect symptom cluster, sickness symptom cluster, and gastrointestinal symptom cluster (χ2 = 1,552.282, Df = 78, P < 0.001). Symptom clusters, illness perceptions, and QoL were significantly correlated. Symptom clusters had significant direct (β = −0.38, P < 0.001) and indirect effects (β = −0.21, P < 0.001) on QoL.ConclusionIllness perceptions played a significant mediating role between symptom clusters and QoL in cervical cancer patients receiving CCRT. Strategies like prompting effective symptom management for the purposes of alleviating illness perceptions may contribute to improving their QoL.

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“…6 Fatiguerelated symptom cluster and malnutrition related symptom cluster are common for gastric cancer patients. 54 Our study showed gastric cancer patients had more fatigue compared to other cancers; the possible reason may be lack of energy led by malnutrition and anemia due to appetite loss and vomiting 55 . Advanced cancer patients experience symptoms throughout the disease trajectory, often with greater intensity as death approaches.…”

Section: Characteristics Of Symptoms Prevalence Among Individual Datamentioning

confidence: 61%

Symptomatic Features and Factors Associated With Do-Not-Resuscitate Consent in Advanced Cancer Patients Admitted to Palliative Care Ward

Fan

Yang

et al. 2022

Am J Hosp Palliat Care

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This study aimed to conduct a retrospective cross-sectional study to investigate the prevalence of symptoms and symptom clusters on sociodemographic and disease characteristics, as well as factors associated with Do-Not-Resuscitate (DNR) consent. Advanced cancer patients were enrolled between 2018 and 2020 with available data. Demographic and clinical data were obtained for analysis from Hospital Information System (HIS) in China. Symptom clusters were extracted by hierarchical cluster analysis. Chi-square test and multiple logistic regression were conducted to investigate the prevalence characteristics of symptoms and influencing factors of DNR consent, respectively. 798 advanced cancer patients were enrolled. The most prevalent symptoms were pain (93%), anorexia (36.5%), and sleep disorders (34.2%). High heart rate was associated with poor performance status and more symptoms. Three clusters were extracted: fatigue-related, respiratory-circulatory system, and digestive system symptom clusters. The incidence of symptoms was statistically significant in age, gender, education level, residence, BMI, performance status, distress score, ADL, and primary pain level. The DNR signature rate was 15.5%. Female, distant metastasis, in-ward rescue, and appearance of dyspnea were independent influencing factors of DNR signature. Chinese hospitalized cancer patients had more symptoms burden that were influenced by various demographic characteristics, especially pain and fatigue-related symptoms. Concerning the trajectory of vital signs is important among advanced cancer patients. The DNR signature rate was lower and our finding indicating an urgency to accurately assess the prognosis and give more palliative care education to enhance DNR rates and early signing in Chinese context.

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Symptom Clusters and Quality of Life in Gastric Cancer Patients Receiving Chemotherapy

Cited by 38 publications

References 47 publications

Effects of symptom clusters on quality of life mediated by self‐efficacy among individuals with myasthenia gravis: A structural equation modelling analysis

Effects of symptom clusters on quality of life mediated by self‐efficacy among individuals with myasthenia gravis: A structural equation modelling analysis

Symptom Clusters and Quality of Life in Cervical Cancer Patients Receiving Concurrent Chemoradiotherapy: The Mediating Role of Illness Perceptions

Symptomatic Features and Factors Associated With Do-Not-Resuscitate Consent in Advanced Cancer Patients Admitted to Palliative Care Ward

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