Symptom clusters and symptom interference of HCC patients undergoing TACE: a cross-sectional study in China

Cao, Wenting; Li, Juan; Hu, Chen; Shen, Jie; Liu, Xiangyan; Xu, Yan; Zhixia, Ye

doi:10.1007/s00520-012-1541-5

Cited by 45 publications

(74 citation statements)

References 19 publications

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“…A study conducted in China investigated the presence of symptoms and symptom clusters and their association with symptom interference in patients with hepatocellular carcinoma before and after transcatheter arterial chemoembolization (21). The most severe symptoms were fatigue, distress, sadness, lack of appetite and sleep disturbance which were similar to our findings.…”

Section: Discussionmentioning

confidence: 99%

Symptom Interference Severity and Health-Related Quality of Life in Pulmonary Arterial Hypertension

Matura

McDonough

Carroll

2016

Journal of Pain and Symptom Management

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Context While assessing symptom severity is an important component of evaluating symptoms, understanding those symptoms that interfere with patients’ lives is also key. Pulmonary arterial hypertension (PAH) is a chronic disease resulting in right heart failure and increased mortality. Patients with PAH experience multiple symptoms but we do not know which symptoms and to what extent their symptoms interfere with daily life. Objectives To: 1) describe the prevalence of those symptoms that interfere with life; 2) describe the severity of symptom interference; and 3) determine those sociodemographic and clinical characteristics, and interfering symptoms associated with health-related quality of life (HRQOL) in patients with PAH. Methods A convenience sample of 191 patients with PAH completed a sociodemographic form; the Pulmonary Arterial Hypertension Symptom Interference Scale (PAHSIS) and the Medical Outcomes Survey Short Form-36 (SF-36) to measure HRQOL. Hierarchical multiple linear regression was used to analyze demographic and medical characteristics along with symptom interference from the PAHSIS as predictors of HRQOL from the composite mental and physical health summary scores of the SF-36. Results The most interfering symptoms reported were fatigue, shortness of breath with exertion and difficulty sleeping. Age, gender, functional class, oxygen use, fatigue, dizziness and Raynaud’s phenomenon were associated with the HRQOL physical health summary scores. The symptoms fatigue and SOB while lying down were associated with the HRQOL mental health summary scores. Conclusion Patients with PAH are experiencing multiple symptoms that are interfering with their HRQOL and ability to function.

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Section: Discussionmentioning

confidence: 99%

Symptom Interference Severity and Health-Related Quality of Life in Pulmonary Arterial Hypertension

Matura

McDonough

Carroll

2016

Journal of Pain and Symptom Management

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“…In recent years, the incidence of HCC in China has increased year after year (Zhu, Tan, Peng, Liu, & Song, ). The number of patients with liver cancer in China accounts for approximately 55% of the total number of patients in the world (Cao et al, ). The etiology and exact molecular mechanism of HCC are not fully understood, and the pathogenesis of HCC is a multifactorial and multistep complex process.…”

Section: Introductionmentioning

confidence: 99%

Role of the novel gene BZW2 in the development of hepatocellular carcinoma

Jin

Liao

Zhang

et al. 2019

Journal Cellular Physiology

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Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in adults. Basic leucine zipper and W2 domains 2 (BZW2) is a member of the basic‐region leucine zipper (bZIP) superfamily of transcription factors. Here, we found that BZW2 expression was substantially increased in both human HCC tissues and cell lines, which was correlated with the clinical progression of patients with HCC. Silence of BZW2 in HCC cells by infecting with the lentivirus for delivering BZW2 shRNA (short hairpin RNA), prohibits cell progression, as determined by the suppressed cell proliferation, clonality, invasion, and increased cell apoptosis. Furthermore, overexpression of BZW2 promotes drug resistance of HCC cells, as shown by the attenuated suppression of cell viability and invasion following rapamycin (RAPA) treatment. Mechanistically, overexpression (or silence) of BZW2 in HCC cells significantly stimulates (or decreases) the activation of the PI3K/AKT/mTOR signaling pathway, which is responsible for HCC progression. Thus, increased BZW2 expression in HCC can induce HCC progression and drug resistance via stimulating the PI3K/AKT/mTOR pathway, which may represent a new therapeutic target for HCC.

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“…In order to discuss these combinations of various factors, a variety of approaches have been taken 23 , such as multivariable regression, principal component analysis 24-28 or neural networks 27,29-32 . Regression methods become too complicated for considering complete tumor-environment interactions; and the principal component and neural network analyses provide statistically significant associations for diagnosis and prognosis, which are difficult to interpret in simple clinical terms.…”

Section: Discussionmentioning

confidence: 99%

Macro- and Micro-environmental Factors in Clinical Hepatocellular Cancer

Pančoška

Carr

2014

Seminars in Oncology

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We previously developed a network phenotyping strategy (NPS), a graph theory-based transformation of clinical practice data, for recognition of two primary subgroups of hepatocellular cancer (HCC), called S and L, which differed significantly in their tumor masses. In the current study, we have independently validated this result on 641 HCC patients from another continent. We identified the same HCC subgroups with mean tumor masses 9 cm×n (S) and 22 cm×n (L), p<10−14. The means of survival distribution (not available previously) for this new cohort were also significantly different (S was 12 months, L was 7 months, p<10−5). We characterized nine unique reference patterns of interactions between tumor and clinical environment factors, identifying four subtypes for S- and five subtypes for L-phenotypes, respectively. In L phenotype, all reference patterns were PVT (portal vein thrombosis) positive, all platelet/AFP levels were high, and all were chronic alcohol consumers. L had phenotype landmarks with worst survival. S phenotype interaction patterns were PVT negative, with low platelet/AFP levels. We demonstrated that tumor-clinical environment interaction patterns explained how a given parameter level can have a different significance within a different overall context. Thus, baseline bilirubin is low in S1 and S4, but high in S2 and S3, yet all are S subtype patterns, with better prognosis than in L. Gender and age, representing macro-environmental factors, and bilirubin, INR and AST levels representing micro-environmental factors, had a major impact on subtype characterization. Clinically important HCC phenotypes are therefore represented by complete parameter relationship patterns and cannot be replaced by individual parameter levels.

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Symptom clusters and symptom interference of HCC patients undergoing TACE: a cross-sectional study in China

Cited by 45 publications

References 19 publications

Symptom Interference Severity and Health-Related Quality of Life in Pulmonary Arterial Hypertension

Symptom Interference Severity and Health-Related Quality of Life in Pulmonary Arterial Hypertension

Role of the novel gene BZW2 in the development of hepatocellular carcinoma

Macro- and Micro-environmental Factors in Clinical Hepatocellular Cancer

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