Symptom clusters and their predictors in patients with lung cancer and treated with programmed cell death protein 1 immunotherapy

Zhang, Guolong; Weng, Hui-Wen; Li, Yinghong; Li, Pingdong; Gong, Yucui; Chen, Jieya; Lin, Wei; Zeng, Ling‐Hui; Zeng, Yingchun; Cheng, Andy S. K.

doi:10.1016/j.apjon.2022.100103

Cited by 6 publications

(6 citation statements)

References 42 publications

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“…Prior research has utilized the Anderson Symptom Inventory to categorize cough and shortness of breath as lung cancer-speci c symptom clusters. Additionally, fatigue has repeatedly emerged as the most prevalent and severe symptom, aligning with the ndings of the present study [13,22]. Coughing and shortness of breath are frequently observed clinical manifestations of lung cancer, and their exacerbations may serve as indicators of disease progression or the emergence of medication resistance.…”

Section: Discussionsupporting

confidence: 85%

“…Our study that the neural symptom clusters included pain, numbness or tingling in hands or feet, and sweats, consistent with previous ndings [13,22]. Previous studies have shown that around 68% of patients experience numbness in their hands or feet, stinging or pain within a month of receiving chemotherapy, which affects their physical function during and within years of completion of the treatment, and increases the risk of falls, thereby affecting the quality of life of the patient, and there are very limited options for effective treatment [32,33].…”

Section: Neural Symptom Clusters and Quality Of Lifesupporting

confidence: 92%

“…MSAS was not utilized in any of the previous investigations, our research aligns with two separate papers that have shown symptom clusters in lung cancer patients undergoing immunotherapy. The psychological symptom of sadness was found to be prevalent in both trials [13,22]. Previous studies found that emotional problems affected global quality of life [23,24] which was consistent with our study.…”

Section: Multiple Linear Regression Analysis Of Quality Of Lifesupporting

confidence: 91%

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Symptom Clusters and Quality of Life in Patients With Lung Cancer Receiving Immunotherapy in China

Yang,

Zhu,

Bai

et al. 2023

Preprint

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Objectives: Lung cancer patients undergoing immunotherapyexperience various symptoms that have long-term effects on their quality of life. However, which symptom clusters are expressed and affect patients’ quality of life remain significantly controversial. Therefore, we aimed to explore symptom clusters among lung cancer patients receiving immunotherapy and identify the impact of these clusters on their quality of life. Data Sources: This was a cross-sectional study aimed at exploring the symptom experiences and quality of life of lung cancer patients receiving immunotherapy. The participants were invited to complete the Memorial Symptom Assessment Scale (MSAS) and Quality of Life Quality of Life Questionnaire—Lung Cancer 43 (QLQ-LC43). Principal component analysis, Spearman correlation analyses, and multiple linear regression were used to explore symptom clusters and identify their influence on quality of life. Conclusion: Data from 240 participants was obtained, and identified five symptom clusters: emotion-related, lung cancer-specific, perceptual, skin, and neural symptom clusters. Adjustment for covariates revealed that emotion-related, lung cancer-specific, perceptual symptom clusters were negative predictors of quality of life. The fitted model explained approximately 56% of the variance. Implications for Nursing Practice: This study demonstrated that lung cancer patients receiving immunotherapy experienced symptoms that tended to occur in five clusters (i.e., emotion-related, lung cancer-specific, perceptual, skin, and neural symptoms). Developing interventions for emotion-related, lung cancer-specific, perceptual symptom clusters may effectively improve patients’ quality of life.

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Section: Discussionsupporting

confidence: 85%

Section: Neural Symptom Clusters and Quality Of Lifesupporting

confidence: 92%

Section: Multiple Linear Regression Analysis Of Quality Of Lifesupporting

confidence: 91%

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Symptom Clusters and Quality of Life in Patients With Lung Cancer Receiving Immunotherapy in China

Yang,

Zhu,

Bai

et al. 2023

Preprint

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Section: Introductionmentioning

confidence: 99%

“…Previous studies have demonstrated that during immunotherapy, lung cancer patients experience multiple symptom clusters [44,45]. Current research on symptom clusters in lung cancer patients primarily focuses on the exploration and classi cation of these clusters [19,20,22,35,45]. While the introduction of the symptom cluster concept facilitates the clustered management of symptoms, the lack of differentiation in the primary and secondary relationships can lead to non-targeted management, resulting in ine ciency [37].…”

Section: Introductionmentioning

confidence: 99%

Symptom Clusters and Symptom Network Analysis During Immunotherapy in Lung Cancer Patients

Yang,

Bai,

liu

et al. 2024

Preprint

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Objective: This study aimed to analyze symptoms in lung cancer patients undergoing immunotherapy and to identify core symptom clusters through network analysis, thereby laying the groundwork for effective symptom management programs. Methods: The study involved 240 lung cancer patients receiving immunotherapy. Participants were assessed using the memory symptom scale. Exploratory factor analysis extracted symptoms, and network analysis using JASP 0.17.3 explored centrality indices and density in these symptom networks. Results: Five symptom clusters were identified: emotion-related, lung cancer-specific, perception, skin, and neurological symptom clusters, with a cumulative variance contribution rate of 55.819%. Network analysis revealed sadness as the most intense symptom (rs = 2.189), dizziness as the most central (rc = 1.388), and fatigue as the most significant bridging symptom (rB = 2.575). Conclusion: This study identified five symptom clusters and networks during the immunotherapy in lung cancer patients. The centrality indices and network density from the network analysis can assist healthcare professionals in devising more precise symptom management strategies.

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Symptom clusters and symptom network analysis during immunotherapy in lung cancer patients

Yang,

Bai,

Liu

et al. 2024

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Symptom clusters and their predictors in patients with lung cancer and treated with programmed cell death protein 1 immunotherapy

Cited by 6 publications

References 42 publications

Symptom Clusters and Quality of Life in Patients With Lung Cancer Receiving Immunotherapy in China

Symptom Clusters and Quality of Life in Patients With Lung Cancer Receiving Immunotherapy in China

Symptom Clusters and Symptom Network Analysis During Immunotherapy in Lung Cancer Patients

Symptom clusters and symptom network analysis during immunotherapy in lung cancer patients

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