Symptom clusters of pain, depressed mood, and fatigue in lung cancer: assessing the role of cytokine genes

Reyes‐Gibby, Cielito C.; Swartz, Michael D.; Yu, Xiaoying; Wu, Xifeng; Yennurajalingam, Sriram; Anderson, Karen O.; Spitz, Margaret R.; Shete, Sanjay

doi:10.1007/s00520-013-1885-5

Cited by 54 publications

(49 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Possibly the analyses of symptoms may help to find the underlying causes of associations among clusters of symptoms. Identifying patients at risk who show specific symptoms and assessing the role of genetic polymorphisms may facilitate the development of tailored therapies for lung cancer patients (25).…”

Section: Discussionmentioning

confidence: 99%

Is nutritional status associated with the level of anxiety, depression and pain in patients with lung cancer?

Chabowski¹,

Polański²,

Jankowska‐Polańska³

et al. 2018

J. Thorac. Dis.

View full text Add to dashboard Cite

Background: Nutritional deficiencies are common in lung cancer patients, especially in those with advanced and metastatic cancers. The pathogenesis of the development of nutritional disorders in cancer patients has not been fully explained. The study was performed in order to research associations between nutritional status and mental condition and pain. The aim of the study was to assess the relationship between nutritional status and the level of anxiety, depression and perceived pain in patients with lung cancer. Methods: A total of 257 patients with lung cancer were enrolled. The Mini-Nutritional Assessment (MNA) questionnaire was used to assess their nutritional status; the Hospital Anxiety and Depression Scale (HADS) was used to assess their levels of anxiety and depression; the Visual Analog Scale (VAS) was used to assess levels of perceived pain. Results: The MNA showed that 23% of the study group was malnourished, 33% at risk of malnutrition and 44% displayed a normal nutritional status. The HADS questionnaire showed that 65% of the study group had depressive symptoms and 65% had anxiety. The mean score of the VAS was 4.35. A significant negative correlation between nutritional status and pain was observed (r=−0.65; P<0.001) as well as between nutritional status and anxiety and depression (r=−0.68; P<0.001 and r=−0.60; P<0.001, respectively). Conclusions:The prevalence of nutritional disorders and the intensity of somatic symptoms and psychological distress are high among lung cancer patients. The significant levels of depression, anxiety and pain in patients at risk of malnutrition which were highlighted in comparison to patients with a normal nutritional status indicate the need for early supportive psychotherapy or pharmacological interventions.

show abstract

Section: Discussionmentioning

confidence: 99%

Is nutritional status associated with the level of anxiety, depression and pain in patients with lung cancer?

Chabowski¹,

Polański²,

Jankowska‐Polańska³

et al. 2018

J. Thorac. Dis.

View full text Add to dashboard Cite

show abstract

“…In 10 of these papers (2,3,(48)(49)(50)(51)(52)(53)(54)(55), patients with cancer were evaluated. In the 11th paper (56), elderly individuals with impaired cardiac function or heart failure were evaluated.…”

Section: Mechanistic Considerationsmentioning

confidence: 99%

“…Of the eight studies that evaluated cytokines and inflammation, four of them evaluated for differences in cytokine gene polymorphisms in subgroups of patients with different experiences with a prespecified symptom cluster (eg, low symptom burden vs a high symptom burden) (2,3,50,51). In all four of these studies, associations were found between single-nucleotide polymorphisms (SNPs) in inflammatory genes (eg, interleukin 6 [IL6], IL13, tumor necrosis factor [TNF] alpha, IL4, IL1B, TNFR2, PTGS2, and IL10RB) and a higher symptom burden.…”

Section: Mechanistic Considerationsmentioning

confidence: 99%

Advancing Symptom Science Through Symptom Cluster Research: Expert Panel Proceedings and Recommendations

Miaskowski

Barsevick

Berger

et al. 2017

JNCI J Natl Cancer Inst

339

330

View full text Add to dashboard Cite

An overview of proceedings, findings, and recommendations from the workshop on "Advancing Symptom Science Through Symptom Cluster Research" sponsored by the National Institute of Nursing Research (NINR) and the Office of Rare Diseases Research, National Center for Advancing Translational Sciences, is presented. This workshop engaged an expert panel in an evidenced-based discussion regarding the state of the science of symptom clusters in chronic conditions including cancer and other rare diseases. An interdisciplinary working group from the extramural research community representing nursing, medicine, oncology, psychology, and bioinformatics was convened at the National Institutes of Health. Based on expertise, members were divided into teams to address key areas: defining characteristics of symptom clusters, priority symptom clusters and underlying mechanisms, measurement issues, targeted interventions, and new analytic strategies. For each area, the evidence was synthesized, limitations and gaps identified, and recommendations for future research delineated. The majority of findings in each area were from studies of oncology patients. However, increasing evidence suggests that symptom clusters occur in patients with other chronic conditions (eg, pulmonary, cardiac, and end-stage renal disease). Nonetheless, symptom cluster research is extremely limited and scientists are just beginning to understand how to investigate symptom clusters by developing frameworks and new methods and approaches. With a focus on personalized care, an understanding of individual susceptibility to symptoms and whether a "driving" symptom exists that triggers other symptoms in the cluster is needed. Also, research aimed at identifying the mechanisms that underlie symptom clusters is essential to developing targeted interventions.Patients with chronic conditions, such as cancer and other rare diseases, experience an array of multiple co-occurring symptoms (eg, pain, fatigue, sleep disturbance). When these symptoms remain underdiagnosed and undertreated, they have a negative impact on patient-reported outcomes (PROs) including functional performance, cognitive status, and quality of life (QOL). A reduction in symptom burden in these patients has the potential to improve their capacity to live well over their entire lives. To achieve this goal, a transformation is needed in how multiple co-occurring symptoms are assessed and managed in order to improve patient outcomes and stimulate a reduction in health care utilization and costs. A strategic plan that advances REVIEW

show abstract

“…Nociceptive pain was the major pathophysiological subtype in lung cancer pain, but neuropathic pain accounted for 30% (range 25−32%) of cases [27]. Cytokines associated with inflammation or tissue damage due to tumor growth and spreads have been thought to contribute to pain hypersensitivity by modifying the activity of nociceptors [28]. Furthermore, tumors growing in the vicinity of peripheral nerves can compromise the integrity of the nerve, inducing a neuropathic condition accompanied by persistent pain, hyperalgesia, or allodynia [29].…”

Section: Pathophysiologymentioning

confidence: 99%

Pain Management in Lung Cancer

Nurwidya

Syahruddin

Yunus

2016

Advances in Respiratory Medicine

View full text Add to dashboard Cite

Lung cancer is the leading cause of cancer-related mortality worldwide. Not only burdened by the limited overall survival, lung cancer patient also suffer from various symptoms, such as pain, that implicated in the quality of life. Cancer pain is a complicated and transiently dynamic symptom that results from multiple mechanisms. This review will describe the pathophysiology of cancer pain and general approach in managing a patient with lung cancer pain. The use of opioids, nonsteroidal anti-inflammatory drugs (NSAIDs), and adjuvant analgesia, as part of the pharmacology therapy along with interventional strategy, will also be discussed.

show abstract

Symptom clusters of pain, depressed mood, and fatigue in lung cancer: assessing the role of cytokine genes

Cited by 54 publications

References 41 publications

Is nutritional status associated with the level of anxiety, depression and pain in patients with lung cancer?

Is nutritional status associated with the level of anxiety, depression and pain in patients with lung cancer?

Advancing Symptom Science Through Symptom Cluster Research: Expert Panel Proceedings and Recommendations

Pain Management in Lung Cancer

Contact Info

Product

Resources

About