Symptom Control and Palliative Care in Hematopoietic Stem Cell Transplantation

Kim, Sola; Nguyen, Nhu Nhu; Haider, Ali

doi:10.1016/b978-0-323-56802-9.00027-4

Cited by 2 publications

(2 citation statements)

References 80 publications

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“…Mucositis is the most common and most severe non-haematological complication of cancer chemo- or radiotherapy [ 1 ]. The treatment is focused on pain management and the use of natural anti-inflammatory and sometimes weakly antiseptic compounds in combination with optimal oral cavity hygiene.…”

Section: Introductionmentioning

confidence: 99%

A 3D Model of Human Buccal Mucosa for Compatibility Testing of Mouth Rinsing Solutions

et al. 2023

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Oral mucositis is the most common and severe non-hematological complication associated with cancer radiotherapy, chemotherapy, or their combination. Treatment of oral mucositis focuses on pain management and the use of natural anti-inflammatory, sometimes weakly antiseptic mouth rinses in combination with optimal oral cavity hygiene. To prevent negative effects of rinsing, accurate testing of oral care products is necessary. Due to their ability to mimic realistic in-vivo conditions, 3D models may be an appropriate option in compatibility testing of anti-inflammatory and antiseptically effective mouth rinses. We present a 3D model of oral mucosa based on the cell line TR-146 with a physical barrier, characterized by high transepithelial electrical resistance (TEER) and confirmed cell integrity. Histological characterization of the 3D mucosa model showed a stratified, non-keratinized multilayer of epithelial cells similar to that of human oral mucosa. By means of immuno-staining, tissue-specific expression of cytokeratin 13 and 14 was shown. Incubation of the 3D mucosa model with the rinses had no effects on cell viability, but TEER decreased 24h after incubation in all solutions except ProntOral®. Analogous to skin models, the established 3D model meets the quality control criteria of OECD guidelines and may therefore be suitable for comparing the cytocompatibility of oral rinses.

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Section: Introductionmentioning

confidence: 99%

A 3D Model of Human Buccal Mucosa for Compatibility Testing of Mouth Rinsing Solutions

et al. 2023

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“…Another particularly useful tool is that developed by the National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events, in short, NCI-CTCAE, which is based on clinical examination, combined with functionality evaluation and local symptoms. In this regard, the oral mucosa is assessed as having 5 grades, starting with grade 1 with mucosal erythema, minimal symptoms, normal swallowing and unchanged diet, and going up to grade 4, in which advanced local necrosis is present, having significant spontaneous life-threatening bleeding with subsequent patient death (grade 5) [31].…”

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confidence: 99%

Oral Mucositis Induced by Chemoradiotherapy in Head and Neck Cancer—A Short Review about the Therapeutic Management and the Benefits of Bee Honey

et al. 2022

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Background and Objectives: Oral mucositis, a severe non-hematological complication, can be induced by chemoradiotherapy. It is associated with severe local dysfunction, severely affecting the patient’s quality of life; it increases the risk of oral infections and interrupts oncological treatment, thus prolonging the duration and cost of hospitalization. Besides all of the agents used in the prevention and treatment of oral mucositis induced by oncological treatment, can there be found an easier one to administer, with an effective preparation, high addressability, both for adults and paediatric patients, without side effects, and at the same time cheap and easy to purchase? The aim of the present paper is to demonstrate the existence of this product, which is available to everyone, having multiple benefits. Materials and Methods: For the purpose of writing this article, materials were searched in electronic databases in between 2019 and 2021, taking into consideration papers where authors have demonstrated the effectiveness of this product through its topical or systemic use. Results: Numerous studies have highlighted the benefits of honey on oral mucositis. Through its analgesic, anti-inflammatory, anti-cancerous and antibacterial action, honey has proved to have a major impact on the patient’s quality of life and nutritional status by promoting tissue epithelialization and healing of the chemoradiotherapy-induced lesions. Conclusions: Superior to many natural agents, bee honey can be successfully used in both preventing and treating oral mucositis. There are currently numerous studies supporting and recommending the use of bee honey in the management of this oncological toxicity.

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Symptom Control and Palliative Care in Hematopoietic Stem Cell Transplantation

Cited by 2 publications

References 80 publications

A 3D Model of Human Buccal Mucosa for Compatibility Testing of Mouth Rinsing Solutions

A 3D Model of Human Buccal Mucosa for Compatibility Testing of Mouth Rinsing Solutions

Oral Mucositis Induced by Chemoradiotherapy in Head and Neck Cancer—A Short Review about the Therapeutic Management and the Benefits of Bee Honey

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