Symptom Dimensions of Depression and Anxiety and the Metabolic Syndrome

Luppino, Floriana S.; Dortland, Arianne K. B. van Reedt; Wardenaar, Klaas J.; Bouvy, Paul F.; Giltay, Erik J.; Zitman, Frans G.; Penninx, Brenda W. J. H.

doi:10.1097/psy.0b013e31820a59c0

Cited by 52 publications

(35 citation statements)

References 59 publications

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“…Maybe this finding occurred by chance due to the small sample size and should be confirmed in futures studies. On the other hand, the association between MetS and role emotional domain can be explained and corroborated by the already know association of MetS with depression and anxiety [26,[54][55][56][57], because this domain analyze role limitations due to emotional problems.…”

Section: Discussionmentioning

confidence: 92%

Association between metabolic syndrome and quality of life

Saboya

Bodanese²,

Zimmermann³

et al. 2016

Sci Med

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Aims: Despite all progress made in understanding and treating metabolic syndrome, the study of its impact on quality of life is still controversial and not well understood. The aim of this study was to test the hypothesis that metabolic syndrome can be associated with a worse quality of life. Methods: A controlled cross-sectional study included individuals with metabolic syndrome, from the sub-analysis of a randomized clinical trial about lifestyle modification and cardiovascular risk factors, as well as individuals with no metabolic syndrome, attended as outpatients in several clinics at a general university hospital in Southern Brazil. Measurements were made in individual interviews and included data collection, laboratory tests, and application of general scales such as Mini-Mental State Examination and Medical Outcomes Study Short Form, General Health Survey (SF-36). Comparisons of quantitative data used the Student's t test, followed by analysis of covariance or multiple linear regression for adjustment, and correlation coefficient. For categorical data, the Chi-square or Fisher's exact test were used. Results: The study included 229 individuals, 118 metabolic syndrome and 111 no metabolic syndrome. In univariate analysis, metabolic syndrome was significantly associated with lower scores in the social functioning (p<0.001) and role emotional (p=0.019) quality of life domains, and with the Mental Component Summary score of the SF-36 (p=0.013). However, after adjustments for confounding factors, especially body mass index, the significance of these associations was lost. The only significant association between metabolic syndrome and quality of life that has remained after the adjustments was with worse QOL in the role emotional domain, but only in men (p=0.049). Conclusions: After adjusting for multiple variables, metabolic syndrome was significantly associated with decreased quality of life scores in men in the role emotional domain.Key woRds: metabolic syndrome X; risk factors; quality of life.RESuMO objetivos: Apesar dos avanços no entendimento e tratamento da síndrome metabólica, o estudo do seu impacto sobre a qualidade de vida é ainda controverso e inconclusivo. O objetivo deste estudo foi testar a hipótese de que a síndrome metabólica estaria associada à piora da qualidade de vida. Métodos: Um estudo transversal controlado incluiu indivíduos com síndrome metabólica, advindos da subanálise de um estudo controlado randomizado sobre modificação de estilo de vida e fatores de risco cardiovascular; e indivíduos sem síndrome metabólica, provenientes de diversos ambulatórios de um hospital geral no sul do Brasil. As medidas foram realizadas em entrevistas individuais, que incluíram coleta de dados demográficos, testes laboratoriais e aplicação do Exame do Estado Mental e o Medical Outcome Study Short Form, General Health Survey (SF-36). Para comparações entre dados quantitativos, foram utilizados teste t de Student, análise de covariância ou regressão linear múltipla para os ajustes dos fatores confu...

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Section: Discussionmentioning

confidence: 92%

Association between metabolic syndrome and quality of life

Saboya

Bodanese²,

Zimmermann³

et al. 2016

Sci Med

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“…However, a sensitivity analysis of including this article did not change the results. Two articles (12,13) used the same samples as the other two studies (14,15), and articles with longer follow-up and more detailed information were retained (14,15). Finally, 39 articles were included (for the complete references of the 39 articles, please see references in Supplementary Data).…”

Section: Resultsmentioning

confidence: 99%

Bidirectional Association Between Depression and Metabolic Syndrome

Pan

Keum

Okereke³

et al. 2012

Diabetes Care

632

393

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OBJECTIVEEpidemiological studies have repeatedly investigated the association between depression and metabolic syndrome (MetS). However, the results have been inconsistent. This meta-analysis aimed to summarize the current evidence from cross-sectional and prospective cohort studies that evaluated this association.RESEARCH DESIGN AND METHODSMEDLINE, EMBASE, and PsycINFO databases were searched for articles published up to January 2012. Cross-sectional and cohort studies that reported an association between the two conditions in adults were included. Data on prevalence, incidence, unadjusted or adjusted odds ratio (OR), and 95% CI were extracted or provided by the authors. The pooled OR was calculated separately for cross-sectional and cohort studies using random-effects models. The I2 statistic was used to assess heterogeneity.RESULTSThe search yielded 29 cross-sectional studies (n = 155,333): 27 studies reported unadjusted OR with a pooled estimate of 1.42 (95% CI 1.28–1.57; I2 = 55.1%); 11 studies reported adjusted OR with depression as the outcome (1.27 [1.07–1.57]; I2 = 60.9%), and 12 studies reported adjusted OR with MetS as the outcome (1.34 [1.18–1.51]; I2 = 0%). Eleven cohort studies were found (2 studies reported both directions): 9 studies (n = 26,936 with 2,316 new-onset depression case subjects) reported adjusted OR with depression as the outcome (1.49 [1.19–1.87]; I2 = 56.8%), 4 studies (n = 3,834 with 350 MetS case subjects) reported adjusted OR with MetS as the outcome (1.52 [1.20–1.91]; I2 = 0%).CONCLUSIONSOur results indicate a bidirectional association between depression and MetS. These results support early detection and management of depression among patients with MetS and vice versa.

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“…The rate of the metabolic syndrome is especially high among persons with anxiety [121] and psychiatric disorders [122], including PTSD, as outlined in work by Pervanidou and Chrousos [68] as well as Rasmusson et al [65]. PTSD patients with comorbid depression appear to be at even greater risk for the metabolic syndrome [65,123].…”

Section: Metabolic Syndromementioning

confidence: 99%

Posttraumatic Stress Disorder and Cardiometabolic Disease

Levine¹,

Levine

Levine³

2013

Cardiology

133

118

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The need for addressing posttraumatic stress disorder (PTSD) among combat veterans returning from Afghanistan and Iraq is a growing public health concern. Current PTSD management addresses psychiatric parameters of this condition. However, PTSD is not simply a psychiatric disorder. Traumatic stress increases the risk for inflammation-related somatic diseases and early mortality. The metabolic syndrome reflects the increased health risk associated with combat stress and PTSD. Obesity, dyslipidemia, hypertension, diabetes mellitus, and cardiovascular disease are prevalent among PTSD patients. However, there has been little appreciation for the need to address these somatic PTSD comorbidities. Medical professionals treating this vulnerable population should screen patients for cardiometabolic risk factors and avail themselves of existing preventive diet, exercise, and pharmacologic modalities that will reduce such risk factors and improve overall long-term health outcomes and quality of life. There is the promise that cardiometabolic preventive therapy complementing psychiatric intervention may, in turn, help improve the posttraumatic stress system dysregulation and favorably impact psychiatric and neurologic function.

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Symptom Dimensions of Depression and Anxiety and the Metabolic Syndrome

Abstract: Our results demonstrate a strong association of most of the MetSyn components with the SA dimension, but not with the NA and PA scales.

Cited by 52 publications

References 59 publications

Association between metabolic syndrome and quality of life

Association between metabolic syndrome and quality of life

Bidirectional Association Between Depression and Metabolic Syndrome

Posttraumatic Stress Disorder and Cardiometabolic Disease

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