(250 words)Context: Breathlessness, fatigue, and anxiety are distressing symptoms for patients with advanced lung cancer. Usually managed as isolated symptoms, they can often occur simultaneously. Previous research has often addressed management of discrete symptoms rather than considering them as a cluster, which in reality is the situation faced by patients.Objectives: This study aims to examine the effectiveness of a psychoeducational intervention (PEI) on the symptom cluster of anxiety, breathlessness and fatigue, compared with usual care.
Methods:A pre-test post-test 2-group randomized controlled trial was conducted.Education on symptom management and coaching in the use of progressive muscle relaxation were delivered to patients one week prior to commencing radiotherapy (RT), and repeated 3 weeks after the first. Symptom data were collected at 4 time points: prior to the intervention, 3 weeks, 6 weeks, and 12 weeks post intervention.Results: 140 lung cancer patients receiving palliative RT were recruited from a public funded hospital in Hong Kong. Doubly multivariate MANOVA revealed a significant difference (Time *group interaction effect, p = .003) over time between the PEI and usual care control group on the pattern of change of the symptom cluster. Significant effects on the patterns of changes in breathlessness (p = .002), fatigue (p = .011), anxiety (p = .001) and functional ability (p = .000) were also found.
4Conclusions: PEI was a promising treatment for relieving the symptom cluster and each of the individually assessed symptoms. More effort needs to be directed at studying impact of interventions on common symptom clusters.