Symptom duration versus survival in non‐emergency colorectal cancer

Olsson, Louise; Bergkvist, Leif; Ekbom, Anders

doi:10.1080/00365520310005342

Cited by 28 publications

(20 citation statements)

References 18 publications

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“…This seems consistent with the published data on the lack of s relationship between the duration of symptoms and mortality in patients with colorectal cancer, even when corrected for possible confounders (6,16,(18)(19)(20)(21)(22).…”

Section: Discussionsupporting

confidence: 81%

The relation of presenting symptoms with staging, grading, and postoperative 3-year mortality in patients with stage I–III nonmetastatic colon cancer

Bedir¹,

Kızıltaş²,

Köstek³

et al. 2016

Turk J Gastroenterol

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Section: Discussionsupporting

confidence: 81%

The relation of presenting symptoms with staging, grading, and postoperative 3-year mortality in patients with stage I–III nonmetastatic colon cancer

Bedir¹,

Kızıltaş²,

Köstek³

et al. 2016

Turk J Gastroenterol

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“…However, none of the patients with positive family history for CRC was diagnosed by screening and a multivariate analysis including the stage did not reduce the likelihood of better survival in patients with positive family history for CRC. Regarding earlier diagnosis, a study on patients with positive family history of cancer displayed that they do not seek help earlier for their symptoms than those with no family history [31]. Other possible explanations for the survival differences and the difference in T stage are tumor biologic factors, such as microsatellite instability (MSI) [32], MSI tumors have a more indolent biology, thus, diminishing the potential for developing lymph node and distant metastases [33,34].…”

Section: Discussionmentioning

confidence: 97%

The correlation between a family history of colorectal cancer and survival of patients with colorectal cancer

et al. 2009

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The purpose was to analyze survival of patients with colorectal cancer and a positive family history for colorectal cancer in first degree relatives compared with those with no such family history and to determine whether differences in survival could be explained by known clinico-pathological factors. During 2000-2003, 318 consecutive patients with colorectal cancer answered a written questionnaire about their family history for colorectal cancer. During a 6-year follow-up, recurrences and survival were registered. Thirty-one (10%) patients had a first-degree relative with colorectal cancer, moreover two patients fulfilled the criteria of hereditary non-polyposis colorectal cancer and were excluded. Patients with a first-degree relative with colorectal cancer had better survival and lower risk for recurrences compared to those with no relatives with colorectal cancer. In a multivariate analysis including age, gender, stage of disease, tumor differentiation, vascular invasion and family history, patients with first-degree relatives with colorectal cancer had lower risks for death (RR 0.37; 95% CI 0.17-0.78) and death from cancer (RR 0.25; 95% CI 0.08-0.80), compared to those with a no relative with colorectal cancer. The differences were seen in patients with colon cancer but not rectal cancer. Family history for colorectal cancer in a first-degree relative is an individual prognostic factor in patients with colon cancer and could not be explained by known clinico-pathological factors. The value of family history taking in patients with colon cancer is therefore not only to identify families with hereditary colorectal cancer, but also to add information to the prognosis of the patients.

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“…23,24 Pathologic analysis by Burton et al 24 of 445 colonic tumor and rectal tumor specimens retrieved during elective and emergency operations demonstrated that T4, N2, and poorly differentiated tumors (themselves indicators of poor outcome) were more likely to present first in an emergency. Retrieval of an appropriate number of lymph nodes is important in staging colorectal cancer.…”

Section: The Unitedmentioning

confidence: 99%

Emergency First Presentation of Colorectal Cancer Predicts Significantly Poorer Outcomes

Bass

Fleming²,

Conneely³

et al. 2009

Diseases of the Colon &Amp; Rectum

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PURPOSE: Colorectal cancer commonly presents first as an emergency and is likely to be complicated by bowel obstruction/perforation requiring more difficult procedures, with poorer outcomes. Analysis of all of the procedures performed on patients diagnosed in Wexford General Hospital, Ireland, during the period 2000 to 2006 was carried out to validate this hypothesis in our western European population.METHODS: Retrospective analysis of a prospectively maintained database of patient demographics, diagnosis, procedures, and mode of presentation (elective, emergency) was undertaken. RESULTS: A total of 356 patients with colorectal cancer underwent 498 procedures during the years 2000 to 2006.Eighty-four emergency endoscopies and 100 emergency bowel resections were performed. Obstructive lesions were more likely to require emergency resection (P G 0.001). Median survival time for patients treated electively was 82 months vs. 59 months for patients treated on an emergency basis.CONCLUSIONS: Of all colonic resections, 34 percent were carried out as emergencies and were significantly more likely to be complicated by obstruction or perforation (P G 0.001). Emergency resections were associated with a significantly poorer perioperative mortality and five-year survival rate (P G 0.001). Forty-one percent of colorectal cancers diagnosed at endoscopy were first seen emergently. These data raise concerns regarding public awareness of colorectal cancer and resource allocation and reemphasize the need for a national colorectal screening program.

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Symptom duration versus survival in non‐emergency colorectal cancer

Abstract: To diminish the impact of colorectal cancer on public health, strategies other than a shortening of symptom duration are needed.

Cited by 28 publications

References 18 publications

The relation of presenting symptoms with staging, grading, and postoperative 3-year mortality in patients with stage I–III nonmetastatic colon cancer

The relation of presenting symptoms with staging, grading, and postoperative 3-year mortality in patients with stage I–III nonmetastatic colon cancer

The correlation between a family history of colorectal cancer and survival of patients with colorectal cancer

Emergency First Presentation of Colorectal Cancer Predicts Significantly Poorer Outcomes

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