Symptom management: the utility of regional cooling for hand-foot syndrome induced by pegylated liposomal doxorubicin in ovarian cancer

Bun, Seiko; Yunokawa, Mayu; Tamaki, Y.; Shimomura, Akihiko; Shimoi, Tatsunori; Kodaira, Makoto; Shimizu, Chikako; Yonemori, Kan; Fujiwara, Yasuhiro; Makino, Yoshinori; Terakado, Hiroyuki; Tamura, Kenji

doi:10.1007/s00520-018-4054-z

Cited by 28 publications

(23 citation statements)

References 14 publications

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“…As previously described, PEGylation may extend the blood circulation time of liposomes and improve accumulation in tumor tissues, hence reducing related adverse effects (e.g., cardiotoxicity). However, PLD causes specific side effects, such as handfoot syndrome (HFS), hypersensitivity reaction, stomatitis and mucositis (Bozzuto and Molinari 2015;Chang and Yeh 2012;Zhao et al 2017;Casadei et al 2018;Jung et al 2017;Bun et al 2018). PLDs are small enough to pass through the vasculature in both tumor and healthy organs, including the skin (Bun et al 2018).…”

Section: Doxorubicin and Daunorubicinmentioning

confidence: 99%

“…Thus, PLDs are secreted in sweat after intravenous infusion. This causes an oxidant/antioxidant imbalance in the skin, since doxorubicin and the Cu(II) ions that are abundant in skin tissue generate reactive oxygen species, leading to HFS lesions (Jung et al 2017;Bun et al 2018). As Table 7 shows, only > 3rd grade stomatitis/mucositis and HFS appeared in the PLD studies, but not in the three studies that used Myocet ® , a non-PEGylated version of liposomal doxorubicin formulation (NPLD).…”

Section: Doxorubicin and Daunorubicinmentioning

confidence: 99%

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Nanomedicine review: clinical developments in liposomal applications

et al. 2019

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Background Many conventional drugs exhibit poor pharmacokinetics, limited bioavailability and a high toxicity, all of which restrain their use. To overcome these issues and improve the therapeutic indexes of the drug, the emergent fields of nanotechnology and nanomedicine have made significant progress in detection, diagnosis and treatment of several diseases at clinical level (Li et al. 2014; Yingchoncharoen et al. 2016; Signorell et al. 2018). In fact, thanks to nanoparticles and liposomes, it has been possible to decrease the toxicity and improve the pharmacokinetics parameters, such as distribution, increased circulation time, targeted controlled release, increased intracellular concentration, and

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Section: Doxorubicin and Daunorubicinmentioning

confidence: 99%

Section: Doxorubicin and Daunorubicinmentioning

confidence: 99%

Nanomedicine review: clinical developments in liposomal applications

et al. 2019

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“…The severity of PPE may range from mild erythema to severe skin damage causing temporary invalidity to the patient ( Figure 2 ). It must be mentioned that this skin affection is temporary, and the patients show a complete restitution after 2–3 weeks [ 21 , 31 ]. Dosage reduction seems to have little impact on the occurrence of PPE.…”

Section: Side Effects Of Pld Treatmentmentioning

confidence: 99%

Therapeutic Apheresis, Circulating PLD, and Mucocutaneous Toxicity: Our Clinical Experience through Four Years

et al. 2020

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Cancer treatment has been greatly improved by the combined use of targeted therapies and novel biotechnological methods. Regarding the former, pegylated liposomal doxorubicin (PLD) has a preferential accumulation within cancer tumors, thus having lower toxicity on healthy cells. PLD has been implemented in the targeted treatment of sarcoma, ovarian, breast, and lung cancer. In comparison with conventional doxorubicin, PLD has lower cardiotoxicity and hematotoxicity; however, PLD can induce mucositis and palmo-plantar erythrodysesthesia (PPE, hand-foot syndrome), which limits its use. Therapeutical apheresis is a clinically proven solution against early PLD toxicity without hindering the efficacy of the treatment. The present review summarizes the pharmacokinetics and pharmacodynamics of PLD and the beneficial effects of extracorporeal apheresis on the incidence of PPE during chemoradiotherapy in cancer patients.

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“…The prevention guidelines for HFS currently consist of avoidance of extreme temperature, irritants, or friction and application of emollients (Qiao and Fang, 2012). Small prospective and retrospective studies investigating regional cooling (ice packs applied to the wrists and ankles or frozen gloves/socks) during PLD infusion in patients with ovarian and other gynecologic cancers showed a significantly reduced incidence or delayed onset of HFS (Bun et al, 2018, Mangili et al, 2008, Molpus et al, 2004, Sayer et al, 2006). Some cancer centers offer regional cryotherapy as a preventive measure.…”

Section: Traditional Chemotherapymentioning

confidence: 99%

Dermatologic conditions in women receiving systemic cancer therapy

Ferreira

Ramseier

Leventhal

2019

International Journal of Women's Dermatology

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As advances in cancer therapies have improved cancer-related survival, novel therapeutics have also introduced a variety of dermatologic toxicities, and an increased number of patients are living with these sequalae. Women with cancer in particular experience a spectrum of dermatologic conditions that affect their skin, hair, nail, and mucosal surfaces. Studies have shown that these toxic effects can significantly affect quality of life and alter a woman’s self-image, cultural identity, femininity, sexuality, and mental health. In severe instances, dermatologic toxicities may even disrupt cancer therapy and can therefore affect overall survival and treatment response. In this article, we review the dermatologic adverse effects from traditional chemotherapy, targeted therapy, immune checkpoint inhibitors, and endocrine therapy that disproportionately affect women. The timely diagnosis and management of these dermatologic conditions is crucial in the multidisciplinary care of women with cancer.

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Symptom management: the utility of regional cooling for hand-foot syndrome induced by pegylated liposomal doxorubicin in ovarian cancer

Abstract: Our study indicates that FGS is a safe, simple method with good tolerability. A prospective study is needed for further assessment.

Cited by 28 publications

References 14 publications

Nanomedicine review: clinical developments in liposomal applications

Nanomedicine review: clinical developments in liposomal applications

Therapeutic Apheresis, Circulating PLD, and Mucocutaneous Toxicity: Our Clinical Experience through Four Years

Dermatologic conditions in women receiving systemic cancer therapy

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