Symptom Profile of Major Depressive Disorder in Women with Eating Disorders

Fernández‐Aranda, Fernando; Pinheiro, Andréa Poyastro; Tozzi, Federica; Via, Maria La; Thornton, Laura M.; Plotnicov, Katherine; Kaye, Walter H.; Fichter, Manfred M.; Halmi, Katherine A.; Kaplan, Allan S.; Woodside, D. Blake; Klump, Kelly L.; Strober, Michael; Crow, Scott J.; Mitchell, James E.; Rotondo, Alessandro; Keel, Pamela K.; Berrettini, Wade H.; Rickels, Karl; Crawford, Steven; Brandt, Harry; Johnson, Craig; Bulik, Cynthia M.

doi:10.1080/00048670601057718

Cited by 92 publications

(58 citation statements)

References 51 publications

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“…12 Present findings seem to be in agreement with previous results showing that UMs are more frequent among suicide cases, 13 persistent mood-disordered patients 14 and among women with symptoms of depression, 15 which usually overlap with ED. [16][17][18] In addition, we have previously reported that PMs are less frequent among schizophrenic patients than among healthy subjects (2.3 vs 8.5%, respectively), 19 which would be in accordance with lower scores on a measure of risk to psychopathology or general distress also found among PM healthy volunteers. 11 Moreover, PMs seem to perform better on a cognitive task that assesses sustained attention, a trait characteristically impaired in patients with schizophrenia, bipolar depression and attention and deficit hyperactive disorder.…”

Section: Discussionsupporting

confidence: 75%

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CYP2D6 polymorphism in patients with eating disorders

et al. 2010

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CYP2D6 polymorphism is associated with variability in drug response, endogenous metabolism (that is, serotonin), personality, neurocognition and psychopathology. The relationship between CYP2D6 genetic polymorphism and the risk of eating disorders (ED) was analyzed in 267 patients with ED and in 285 controls. A difference in the CYP2D6 active allele distribution was found between these groups. Women carrying more than two active genes (ultrarapid metabolizers) (7.5 vs 4.6%) or two (67 vs 58.9%) active genes were more frequent among patients with ED, whereas those with one (20.6 vs 30.2%) or zero active genes (4.9 vs 6.3%) were more frequent among controls (Po0.05). Although further research is needed, present findings suggest an association between CYP2D6 and ED. CYP2D6 allele distribution in patients with ED seems related to increased enzyme activity.

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Section: Discussionsupporting

confidence: 75%

“…15 In addition, altered serotonin neurotransmission and associated comorbid affective disorders are frequently described in ED. [16][17][18] Thus, in light of these observations, we aimed to analyze the relationship between CYP2D6 genetic polymorphism and susceptibility to ED.…”

Section: Introductionmentioning

confidence: 99%

CYP2D6 polymorphism in patients with eating disorders

et al. 2010

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“…We have recently reported increased BDNF levels for ED [11] . Moreover, high comorbidity between ED and Axis I or Axis II disorders, such as affective disorders, personality disorders, anxiety disorders, obsessive compulsive disorders, impulse control disorders and substance abuse, has been described [13][14][15][16][17][22][23][24] . Accordingly, the degree of comorbidity could be modulated by BDNF expression levels.…”

Section: Discussionmentioning

confidence: 99%

“…have been reported in the literature [22][23][24] and are linked to ED severity [25] and poorer prognosis [26] .…”

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confidence: 99%

Blood Levels of Brain-Derived Neurotrophic Factor Correlate with Several Psychopathological Symptoms in Anorexia Nervosa Patients

et al. 2007

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Background: Evidence of a role of brain-derived neurotrophic factor (BDNF) in the pathophysiology of eating disorders (ED) has been provided by association studies and by murine models. BDNF plasma levels have been found altered in ED and in psychiatric disorders that show comorbidity with ED. Aims: Since the role of BDNF levels in ED-related psychopathological symptoms has not been tested, we investigated the correlation of BDNF plasma levels with the Symptom Checklist 90 Revised (SCL-90R) questionnaire in a total of 78 ED patients. Methods: BDNF levels, measured by the enzyme-linked immunoassay system, and SCL-90R questionnaire, were assessed in a total of 78 ED patients. The relationship between BDNF levels and SCL-90R scales was calculated using a general linear model. Results: BDNF plasma levels correlated with the Global Severity Index and the Positive Symptom Distress Index global scales and five of the nine subscales in the anorexia nervosa patients. BDNF plasma levels were able to explain, in the case of the Psychoticism subscale, up to 17% of the variability (p = 0.006). Conclusion: Our data suggest that BDNF levels could be involved in the severity of the disease through the modulation of psychopathological traits that are associated with the ED phenotype.

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“…7 AN is often comorbid with major depressive disorder, anxiety disorders, and multiple somatic complications. [8][9][10][11][12] Although most individuals recover, ~25% develop a chronic and relapsing course. 13 AN ranks among the ten leading causes of disability among young women 14 and has one of the highest mortality rates of any psychiatric disorder.…”

Section: Introductionmentioning

confidence: 99%