Symptom severity and attitudes toward medication: Impacts on adherence in outpatients with schizophrenia

Medication-related factors of non adherence among patients with schizophrenia and bipolar disorder: Outcome of a cross-sectional survey in Maiduguri, North-eastern Nigeria

“…This roughly translates to every four and every six out of ten subjects with bipolar disorder and schizophrenia were nonadherent, while overall, over five subjects out of ten across the diagnostic groups were nonadherent. This overall non-adherence rate falls within the range of 30 to 65% reported in previous studies by Yang et al (2012) and Kassis et al (2014). The reported higher rate of nonadherence among subjects with schizophrenia than among those with bipolar disorder might be attributed to: higher rate of the prescription of conventional anti- psychotics and their attendant side effects such as the extrapyramidal ones which may encumber adherence, and probable lower levels of insight and residual psychopathology among the schizophrenic subjects in comparison to their bipolar disorder counterparts that might have negatively affected adherence.…”

“…The reported higher rate of nonadherence among subjects with schizophrenia than among those with bipolar disorder might be attributed to: higher rate of the prescription of conventional anti- psychotics and their attendant side effects such as the extrapyramidal ones which may encumber adherence, and probable lower levels of insight and residual psychopathology among the schizophrenic subjects in comparison to their bipolar disorder counterparts that might have negatively affected adherence. Though, the prevalence of non-adherence reported in this study, falls within the range of most studies conducted earlier by Adewuya et al (2009), Yang et al (2012 and Kassis et al (2014), the rate was below 66.9 and 74% reported in Egypt by Amr et al (2013) and by Banerjee and Varma (2013) in India respectively. This discrepancy could be attributed to the methodological differences in the studies, such as the tools used for the assessment of adherence and the different cut-off values used for the definition of adherence and non-adherence.…”

“…Nonadherence rates among patients with schizophrenia and bipolar disorder ranged between 30 and 65% (Yang et al, 2012;Demoz et al, 2014). In a review of studies published between 1980 and 2000, Lacro et al (2002), reported an unweighted mean non-adherence frequency of 40.5% among patients with schizophrenia.…”

Symptom severity, quality of sleep, and treatment adherence among patients suffering from schizophrenia and depression

“…An association between less severe psychiatric symptoms and better treatment adherence was found, [20] and both the severity of the disease and the patient's attitude towards the prescribed medication were found to be related to adherence in patients with schizophrenia. [21] In this case, the severity was found to correlate negatively with treatment adherence while the patient's attitude towards the prescribed medication was found to correlate positively with treatment adherence.…”

Effect of a Telephone Intervention upon Medication Adherence and Related Outcomes in Outpatients with Schizophrenia Spectrum Disorders (SSDs)

“…Great number (upto 74%) of persons with schizophrenia spectrum disorders (schizophrenia, schizophreniform disorder and schizoaffective disorder-SSDs) are defined as nonadherent (take less than 80% of doses prescribed) to their antipsychotic medications [1], and poor adherence is leading contributor to SSD relapse [2]. Relapses increase disability, shorten remissions and reduce responsiveness to subsequent treatments, all of which increase the likelihood of costly rehospitalizations.…”