Symptomatic Acquired Haemophilia Due to Circulating Antibodies Against Both Factor VIII and IX in a Non-haemophiliac Patient

Abstract

Abstracts Acquired haemophilia is a very rare condition, occurring in less than 2 per million populations. This condition is caused commonly by acquired antibodies against factor VIII and rarely by antibodies against factor IX. Here we describe an extremely rare presentation of idiopathic acquired haemophilia in an otherwise healthy male patient, caused by simultaneous occurrence of circulating antibodies against both factor VIII and IX.

Acquired Hemophilia A: Experience of a Tertiary Care Institute from North India

“…The median age of the AHA patients reported in the literature is approximately 75 years [4]. Our patients are somewhat younger than those reported from other parts of the world but are relatively older than those from our region (median 60 years, range 53.8-56.3 years) [7][8][9][10][11][12][13].…”

“…Data on AHA in the literature is mainly from western countries and case series from China. AHA from India finds mention as an occasional case series or a few case reports [7][8][9][10][11][12][13]. This bleeding disorder occurs predominantly in adults.…”

Acquired FVIII and FIX Inhibitors after Pregnancy: A Case Report

“…An explanation is that the smaller FIX protein may be less immunogenic than the FVIII molecule and therefore less likely to provoke antibody formation [1]; the co-occurrence of inhibitors to multiple coagulation factors, as in our case, is uncommon. Only 6 case reports that describe FVIII and FIX codeficiencies have been published to date [2,3,4,5,6,7]. These autoantibodies may induce spontaneous life-threatening bleeding in patients who have no previous history of bleeding disorder.…”