Symptomatic and Asymptomatic Respiratory Viral Infections in the First Year of Life: Association With Acute Otitis Media Development

Chonmaitree, Tasnee; Alvarez-Fernandez, Pedro; Jennings, Kristofer; Trujillo, Rocio; Marom, Tal; Loeffelholz, Michael J.; Miller, Aaron L.; McCormick, David P.; Patel, Janak A.; Pyles, Richard B.

doi:10.1093/cid/ciu714

Cited by 99 publications

(101 citation statements)

References 29 publications

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“…None of the infants were hospitalised. In a similar study of a panel of viruses by CHONMAITREE et al [8] a virus was identified in 795 (39%) of samples, with two or more viruses in 228 of these. Predictably, rhinovirus was the most commonly identified virus.…”

Section: Identification Of Pathogens and Relationship To Disease Andmentioning

confidence: 84%

Paediatric respiratory infections

Everard

2016

Eur Respir Rev

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Pulmonary infections remain a major cause of infant and child mortality worldwide and are responsible for a substantial burden of morbidity. During the 2015 European Respiratory Society International Congress in Amsterdam, some of the main findings from peer-reviewed articles addressing this topic that were published in the preceding 12 months were reviewed in a Paediatric Clinical Year in Review session. The following article highlights some of the insights provided by these articles into the complex interactions of the human host with the extensive and dynamic populations of microorganisms that call an individual "home". @ERSpublications A review of publications from the past year addressing acute life-threatening and chronic respiratory infections http://ow.ly/W4ahI

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Section: Identification Of Pathogens and Relationship To Disease Andmentioning

confidence: 84%

Paediatric respiratory infections

Everard

2016

Eur Respir Rev

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“…Several studies showed that children who attend day-care centres have an increased risk of ARI, due to the close contact among each other, thus increasing the viral transmission (2,3,34). Moreover, the data was collected in winter, so there was a high frequency of ARI due to seasonality (1,35).…”

Section: Discussionmentioning

confidence: 99%

“…Parents make a considerable use of healthcare services to cope with ARI, thus becoming a burden for children and their families (1,4). Furthermore, ARI are the main cause of worldwide morbidity, leading to school and work absenteeism (5).…”

Section: Introductionmentioning

confidence: 99%

Subjective and objective parameters in paediatric respiratory conditions: cultural adaptation to Portuguese population

et al. 2017

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“…WBC counts and CRP levels are of limited value, and the significance of RV loads as a surrogate marker of disease severity is still inconclusive (10,(46)(47)(48). Our study introduces a proof of concept: The combination of molecular microbiological data and systemic host responses could help in assessment of the significance of pathogen detection and the causality of clinical illness.…”

Section: Original Articlementioning

confidence: 93%

Rhinovirus Detection in Symptomatic and Asymptomatic Children: Value of Host Transcriptome Analysis

Heinonen

Jartti²,

García

et al. 2016

Am J Respir Crit Care Med

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Rationale: Rhinoviruses (RVs) are a major cause of symptomatic respiratory tract infection in all age groups. However, RVs can frequently be detected in asymptomatic individuals.Objectives: To evaluate the ability of host transcriptional profiling to differentiate between symptomatic RV infection and incidental detection in children.Methods: Previously healthy children younger than 2 years old (n = 151) were enrolled at four study sites and classified into four clinical groups: RV2 healthy control subjects (n = 37), RV1 asymptomatic subjects (n = 14), RV1 outpatients (n = 30), and RV1 inpatients (n = 70). Host responses were analyzed using whole-blood RNA transcriptional profiles.Measurements and Main Results: RV infection induced a robust transcriptional signature, which was validated in three independent cohorts and by quantitative real-time polymerase chain reaction with high prediction accuracy. The immune profile of symptomatic RV infection was characterized by overexpression of innate immunity and underexpression of adaptive immunity genes, whereas negligible changes were observed in asymptomatic RV1 subjects. Unsupervised hierarchical clustering identified two main clusters of subjects. The first included 93% of healthy control subjects and 100% of asymptomatic RV1 subjects, and the second comprised 98% of RV1 inpatients and 88% of RV1 outpatients. Genomic scores of healthy control subjects and asymptomatic RV1 children were similar and significantly lower than those of RV1 inpatients and outpatients (P , 0.0001).Conclusions: Symptomatic RV infection induced a robust and reproducible transcriptional signature, whereas identification of RV in asymptomatic children was not associated with significant systemic transcriptional immune responses. Transcriptional profiling represents a useful tool to discriminate between active infection and incidental virus detection.

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Symptomatic and Asymptomatic Respiratory Viral Infections in the First Year of Life: Association With Acute Otitis Media Development

Abstract: Compared to symptomatic infection, asymptomatic viral infection in infants is associated with young age, male sex, low viral load, specific viruses, and single virus detection. Asymptomatic viral infection did not result in AOM.

Cited by 99 publications

References 29 publications

Paediatric respiratory infections

Paediatric respiratory infections

Subjective and objective parameters in paediatric respiratory conditions: cultural adaptation to Portuguese population

Rhinovirus Detection in Symptomatic and Asymptomatic Children: Value of Host Transcriptome Analysis

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