Symptomatic Bilateral Sacroiliitis in a Patient with Juvenile Systemic Lupus Erythematosus: A Rare Association

Gupta, Vikas; Dhanota, Devinderpal Singh

doi:10.31138/mjr.34.1.105

MJR

2023

DOI: 10.31138/mjr.34.1.105

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Symptomatic Bilateral Sacroiliitis in a Patient with Juvenile Systemic Lupus Erythematosus: A Rare Association

Vikas Gupta

Devinderpal Singh Dhanota

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2024

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The Onset of Systemic Lupus Erythematosus Triggers Nucleus Pulposus Cell Pyroptosis to Exacerbate Intervertebral Disc Degeneration

Lao,

Fang,

Shen

et al. 2024

JIR

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Purpose Systemic lupus erythematosus (SLE) is an autoimmune disorder marked by immune system dysregulation and autoantibodies production, causing widespread inflammation and damage across various body systems. Despite the prevalent back pain in SLE patients, the link between SLE and intervertebral disc (IVD) degeneration, a primary contributor to back pain, remains inadequately understood. This study explored the impact of SLE on IVD degeneration using the MRL/ lpr mouse model, which effectively replicates human SLE manifestations. Methods The study utilized MRL/ lpr mice to investigate the effects of SLE on IVD degeneration. The mice were evaluated for typical SLE phenotypes and indicators of IVD degeneration, including IVD height, IVD score, tissue integrity, extracellular matrix degradation, and apoptosis of IVD cells. Additionally, the study examined nucleus pulposus (NP) pyroptosis and inflammatory cytokine secretion. Mechanistic analysis focused on the antioxidant pathway, specifically the expression levels of NRF2, HO-1, KEAP1, and the phosphorylation levels of p65. Results MRL/ lpr mice displayed typical SLE phenotypes and exacerbated profiles of IVD degeneration, including reduced IVD height, lower IVD score, significant IVD tissue impairment, extracellular matrix degradation, and increased apoptosis of IVD cells. Notably, SLE stimulated NP pyroptosis and excessive secretion of inflammatory cytokines. Mechanistic analysis indicated that the progression of SLE impedes the antioxidant pathway by downregulating NRF2 and HO-1 expression, upregulating KEAP1, and enhancing phosphorylation levels of p65. Conclusion Our findings highlight the mechanistic link between SLE and IVD degeneration, suggesting potential therapeutic targets for mitigating back pain in SLE patients.

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The Onset of Systemic Lupus Erythematosus Triggers Nucleus Pulposus Cell Pyroptosis to Exacerbate Intervertebral Disc Degeneration

Lao,

Fang,

Shen

et al. 2024

JIR

View full text Add to dashboard Cite

show abstract

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Symptomatic Bilateral Sacroiliitis in a Patient with Juvenile Systemic Lupus Erythematosus: A Rare Association

Cited by 1 publication

References 16 publications

The Onset of Systemic Lupus Erythematosus Triggers Nucleus Pulposus Cell Pyroptosis to Exacerbate Intervertebral Disc Degeneration

The Onset of Systemic Lupus Erythematosus Triggers Nucleus Pulposus Cell Pyroptosis to Exacerbate Intervertebral Disc Degeneration

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