Symptomatic cerebral vasospasm in the setting of carmustine wafer placement for glioblastoma: A case presentation and review of literature

Khan, Maheen; Cirjan, Cristian; Quadri, Nabiha; Alexopoulos, Georgios; Coppens, Jeroen

doi:10.25259/sni_257_2020

Cited by 3 publications

(2 citation statements)

References 36 publications

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“…Twenty-nine articles reporting 42 cases are included, analyzed, and summarized in Table 1. [1,2,[5][6][7][8]12,[14][15][16][17][18][23][24][25][26][28][29][30]32,33,35,36,38,42,43,[46][47][48]3,11,13,19,20,27,37,39,41,44,45]…”

Section: Resultsmentioning

confidence: 99%

Management of postoperative cerebral vasospasm in skull base surgeries: A systematic review of case reports and series

Hamzah

Alharbi

Abdulhamid

et al. 2023

Surgical Neurology International

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Background: This study provides a comprehensive overview of the management of postoperative vasospasm after skull base surgeries. This phenomenon is rare but can be of serious sequelae. Methods: Medline, Embase, and PubMed Central were searched, along with examining the references of the included studies. Only case reports and series that reported vasospasm following a skull base pathology were incorporated. Cases with pathologies other than skull base, subarachnoid hemorrhage, aneurysm, and reversible cerebral vasoconstriction syndrome were excluded from the study. Quantitative data were presented as mean (Standard Deviation) or median (range), accordingly, while qualitative data were presented as frequency (percentage). Chi- square test and one-way analysis of variance were used to assess for any association between the different factors and patient outcomes. Results: We had a total of 42 cases extracted from the literature. The mean age was 40.1 (±16.1) with approximately equal males and females (19 [45.2%] and 23 [54.8%], respectively). The time to develop vasospasm after the surgery was 7 days (±3.7). Most of the cases were diagnosed by either angiogram or magnetic resonance angiography. Seventeen of the 42 patients had pituitary adenoma as the pathology. Anterior circulation was nearly affected in all patients. For management, most patients received pharmacological with supportive management. Twenty-three patients had an incomplete recovery as a result of vasospasm. Conclusion: Vasospasm following skull base operations can affect males and females, and most patients in this review were middle-aged adults. The outcome of patients varies; however, most patients did not achieve a full recovery. There was no correlation between any factors and the outcome.

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Section: Resultsmentioning

confidence: 99%

Management of postoperative cerebral vasospasm in skull base surgeries: A systematic review of case reports and series

Hamzah

Alharbi

Abdulhamid

et al. 2023

Surgical Neurology International

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“…The major vascular complication after surgery is called cerebral vasospasm and is associated with high morbidity and mortality in the reported cases (~30%) [ 186 ]. The cerebral vasospasm implies a narrowing of the blood vessels resulting in decreased blood flow and eventually ischemia to distal tissues in the brain [ 187 ].…”

Section: Conventional and New Interventions That Target The Endothmentioning

confidence: 99%

Endothelial-Tumor Cell Interaction in Brain and CNS Malignancies

Peleli

Moustakas

Papapetropoulos

2020

IJMS

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Glioblastoma and other brain or CNS malignancies (like neuroblastoma and medulloblastoma) are difficult to treat and are characterized by excessive vascularization that favors further tumor growth. Since the mean overall survival of these types of diseases is low, the finding of new therapeutic approaches is imperative. In this review, we discuss the importance of the interaction between the endothelium and the tumor cells in brain and CNS malignancies. The different mechanisms of formation of new vessels that supply the tumor with nutrients are discussed. We also describe how the tumor cells (TC) alter the endothelial cell (EC) physiology in a way that favors tumorigenesis. In particular, mechanisms of EC–TC interaction are described such as (a) communication using secreted growth factors (i.e., VEGF, TGF-β), (b) intercellular communication through gap junctions (i.e., Cx43), and (c) indirect interaction via intermediate cell types (pericytes, astrocytes, neurons, and immune cells). At the signaling level, we outline the role of important mediators, like the gasotransmitter nitric oxide and different types of reactive oxygen species and the systems producing them. Finally, we briefly discuss the current antiangiogenic therapies used against brain and CNS tumors and the potential of new pharmacological interventions that target the EC–TC interaction.

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Carmustine-polifeprosan-20-wafer

2020

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Symptomatic cerebral vasospasm in the setting of carmustine wafer placement for glioblastoma: A case presentation and review of literature

Cited by 3 publications

References 36 publications

Management of postoperative cerebral vasospasm in skull base surgeries: A systematic review of case reports and series

Management of postoperative cerebral vasospasm in skull base surgeries: A systematic review of case reports and series

Endothelial-Tumor Cell Interaction in Brain and CNS Malignancies

Carmustine-polifeprosan-20-wafer

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