Symptomatic differences and symptoms stability in unipolar and bipolar depression. Medical charts review in 99 inpatients

Gosek, Paweł; Heitzman, Janusz; Stefanowski, Bogdan; Antosik-Wójcińska, Anna; Parnowski, Tadeusz

doi:10.12740/pp/102656

Cited by 8 publications

(9 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Those findings highlight the potential of reward processing deficits related to anhedonia to be trait factors of mood disorders. Interestingly, a recent study demonstrated that anhedonia was more frequent in BD patients compared to MDD patients [34], which is in line with our current findings but opposite to an earlier investigation reported that unipolar depressed patients exhibited greater severity of anhedonia [35]. However, most previous studies did not use specialized tools to assess anhedonia, and this might be the main explanation for the existing discrepancy.…”

Section: Discussionsupporting

confidence: 79%

Anhedonia difference between major depressive disorder and bipolar disorder II

et al. 2021

View full text Add to dashboard Cite

Objective This study aims to explore the difference in anhedonia between Major Depressive Disorder (MDD) and Bipolar Disorder II (BD-II), and attempt to distinguish the two diseases through Snaith-Hamilton Pleasure Scale (SHAPS). Methods A total of 164 drug-free depressive patients (98 MDD patients, 66 BD-II patients) completed the investigation. 17-item Hamilton Depression Scale (HAMD-17) and Hamilton Anxiety Scale (HAMA) and SHAPS were assessed in all participants. Results Our results showed that BD-II patients had higher SHAPS scores than MDD patients. The stepwise logistic regression analysis further revealed that SHAPS score, drinking habit, and extroversion as influencing factors for the identification of BD-II. The ROC curve analysis indicated that SHAPS could differentiate BD-II from MDD patients (AUC = 0.655, P = 0.001, 95% CI = 0.568 to 0.742), with the best screening cutoff at 26, and the corresponding sensitivity and specificity was 0.788 and 0.520, respectively. Conclusion Our results suggest that BD-II patients had more severe anhedonia compared to MDD patients, and the difference in anhedonia may help clinicians preliminary identify BD patients from MDD patients. The preliminary findings are worthly of further exploration.

show abstract

Section: Discussionsupporting

confidence: 79%

Anhedonia difference between major depressive disorder and bipolar disorder II

et al. 2021

View full text Add to dashboard Cite

show abstract

“…7 The relative stability of suicidal ideation across depressive episodes has been replicated in bipolar disorder. 12 Other studies, however, have found sleep disturbance and concentration difficulties to be the most stable symptoms, 13 or all symptoms to have equally low stability. [4][5][6] These inconsistencies and low stability estimates may be influenced by both study design (small samples) and psychometric limitations of the measures used to quantify consistency (i.e.…”

Section: Discussionmentioning

confidence: 99%

“…On the contrary, previous studies have indicated high consistency for anhedonia, at least between two consecutive episodes. 7,13…”

Section: Discussionmentioning

confidence: 99%

Suicidal ideation across depressive episodes: 9-year longitudinal cohort study

Kivelä,

Antypa,

Fried

et al. 2023

BJPsych open

View full text Add to dashboard Cite

Background Depression is a highly recurrent disorder, with more than 50% of those affected experiencing a subsequent episode. Although there is relatively little stability in symptoms across episodes, some evidence indicates that suicidal ideation may be an exception. However, these findings warrant replication, especially over longer periods and across multiple episodes. Aims To assess the relative stability of suicidal ideation in comparison with other non-core depressive symptoms across episodes. Method We examined 490 individuals with current major depressive disorder (MDD) at baseline and at least one subsequent episode during 9-year follow-up within the Netherlands Study of Depression and Anxiety (NESDA). The Inventory of Depressive Symptomatology (IDS) was used to assess DSM-5 non-core MDD symptoms (fatigue, appetite/weight change, sleep disturbance, psychomotor disturbance, concentration difficulties, worthlessness/guilt, suicidal ideation) at baseline and 2-, 4-, 6- and 9-year follow-up. We examined consistency in symptom presentation (i.e. whether the symptom met the diagnostic threshold, based on a binary categorisation of the IDS) using kappa (κ) and percentage agreement, and stability in symptom severity using Spearman correlation, based on the continuous IDS scores. Results Out of all non-core depressive symptoms, insomnia appeared the most stable across episodes (r = 0.55–0.69, κ = 0.31–0.47) and weight decrease the least stable (r = 0.03–0.33, κ = 0.06–0.19). For suicidal ideation, correlations across episodes ranged from r = 0.36 to r = 0.55 and consistency ranged from κ = 0.28 to κ = 0.49. Conclusions Suicidal ideation is moderately stable in recurrent depression over 9 years. Contrary to prior reports, however, it does not exhibit substantially more stability than most other non-core symptoms of depression.

show abstract

“…According to some researchers, there are certain groupings of serotonin neurons in the brain that are over-active in people suffering from depression [ 33 ]. Interestingly, features of increased impulsivity were observed in analyses of symptoms of depressive disorders [ 34 ]. Clinically, drugs affecting serotonergic transmission can be used in the prevention of impulsive and aggressive behavior [ 35 , 36 ].…”

Section: Discussionmentioning

confidence: 99%

Neuropathological Changes in the Brains of Suicide Killers

et al. 2021

Self Cite

View full text Add to dashboard Cite

Background: Homicide combined with subsequent suicide of the perpetrator is a particular form of interpersonal violence and, at the same time, a manifestation of extreme aggression directed against oneself. Despite the relatively well-described individual acts of homicide and suicide, both in terms of psychopathology and law, acts of homicide and subsequent suicide committed by the same person are not well-studied phenomena. The importance of emotional factors, including the influence of mental state deviations (psychopathology), on this phenomenon, is discussed in the literature, but still there is relatively little data with which to attempt neuropathological assessments of the brains of suicide killers. This paper is dedicated to the issue based on the neuropathological studies performed. Methods: We analyzed a group of murder–suicides using histochemical and immunohistochemical methods. Results: The results of our research indicate the presence of neurodegenerative changes including multiple deposits of ß-amyloid in the form of senile/amyloid plaques and perivascular diffuse plaques. Conclusions: Neurodegenerative changes found in the analyzed brains of suicide killers may provide an interesting starting point for a number of analyses. The presence of neurodegenerative changes at such a young age in some murderers may suggest preclinical lesions that affect cognitive functions and are associated with depressed moods.

show abstract

Symptomatic differences and symptoms stability in unipolar and bipolar depression. Medical charts review in 99 inpatients

Cited by 8 publications

References 40 publications

Anhedonia difference between major depressive disorder and bipolar disorder II

Anhedonia difference between major depressive disorder and bipolar disorder II

Suicidal ideation across depressive episodes: 9-year longitudinal cohort study

Neuropathological Changes in the Brains of Suicide Killers

Contact Info

Product

Resources

About