Symptomatic Disseminated Histoplasmosis Acquired by Liver Transplantation

Niyazi, Fadi; Ahmed, Shahzad; Tosch, Kimberly; Mullins, Keith; Jafri, Syed-Mohammed

doi:10.14309/00000434-201510001-00803

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our review of the literature found two case reports that featured presumed donor-derived histoplasmosis after liver transplantation (Table 1). Niyazi et al described a 61-year-old male who received an OLT from a donor that was observed to have granulomatous inflammation of the spleen at autopsy [17]. The OLT recipient was placed on itraconazole for prophylaxis but developed severe infection five months post-transplant after discontinuing his antifungal medication.…”

Section: Modes Of Acquisitionmentioning

confidence: 99%

Histoplasmosis in Liver Transplant Recipients: Case Reports and a Review of the Literature

Spallone¹,

Dhal²,

Woc-Colburn³

et al. 2020

OBM Transplantation

View full text Add to dashboard Cite

We report two cases of histoplasmosis in orthotopic liver transplant (OLT) recipients to illustrate the variable presentations, complications encountered during treatment, the spectrum of diagnostic modalities, and case outcomes. Case 1 describes the insidious presentation of presumed gastrointestinal histoplasmosis 12 years after OLT, which was defined by months of intermittent diarrhea and focal colonic disease on colonoscopy. A diagnosis of Histoplasma capsulatum was ultimately made by broad range PCR performed on colonic tissue. Due to the patient's inability to tolerate itraconazole, treatment consisted of two weeks of liposomal amphotericin B with resolution of colonic ulcers on follow-up colonoscopy. Case 2 illustrates a case of severe pulmonary histoplasmosis with dissemination in an OLT recipient one year after transplantation. Treatment was complicated by the development of acute respiratory distress syndrome requiring mechanical ventilation and hemodynamic shock requiring extracorporeal membrane oxygenation therapy. A review of the literature on histoplasmosis in OLT recipients accompanies our cases and emphasizes the epidemiology, clinical manifestations, diagnosis, treatment, and prevention.

show abstract

Section: Modes Of Acquisitionmentioning

confidence: 99%