Symptomatic gastro-oesophageal reflux disease: double blind controlled study of intermittent treatment with omeprazole or ranitidine

Abstract

Objective To assess intermittent treatment over 12 months in patients with symptomatic gastro-oesophageal reflux disease.

Unmet Needs in the Treatment of Gastroesophageal Reflux Disease

“…This is primarily due to studies showing that most patients with symptomatic GERD (60%) are contented with on-demand or intermittent PPI therapy. 40 On-demand therapy is a self-managed therapeutic strategy in which PPI intake is completely symptom driven, but patients are instructed not to take more than one PPI dose daily. 41 Studies have shown that 50% of the patients who consume PPI daily become on-demand takers within one month.…”

Discontinuation of proton pump inhibitors in patients on long‐term therapy: a double‐blind, placebo‐controlled trial

“…Comparison of gastrointestinal symptom rating scale (GSRS) total score, GSRS reflux score, GSRS abdominal pain score and Glasgow dyspepsia score as well as the psychological general well-being (PGWB) score during the course of the study and in those who had a successful PPI discontinuation Recent studies have shown that many GERD patients take PPIs on demand. 1,[19][20][21][22] In the current study, patients taking PPIs on demand were excluded. Most patients with GERD were willing to continue with PPIs on demand to control their symptoms but 50-60% of patients continued with placebo on demand.…”

Overview: initial and long‐term management of gastro‐oesophageal reflux disease

“…9 There is increasing support for the on-demand approach as the preferred strategy. [10][11][12] For example, Bardhan et al prospectively enrolled 526 patients and treated them with either an H 2 RA or proton pump inhibitor taken as needed. 10 Approximately 50% of the patients did not need to take any acid-suppressive medication for a minimum of 6 of the 12 months of the study.…”