Symptomatic Helicobacter pylori infection in young patients with severe neurologic impairment

Proujansky, Roy; Shaffer, Stephen; Vinton, Nancy E.; Bachrach, Steven J.

doi:10.1016/s0022-3476(06)80175-7

Cited by 24 publications

(14 citation statements)

References 9 publications

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“…As humans are considered to be the sole natural hosts of H. pylori , this suggests that person‐to‐person contact plays a key role in transmission. Physically and mentally disabled children may be particularly exposed to microorganisms because of different feeding abilities, toilet needs, and living and sanitary arrangements, and a higher frequency of H. pylori infection has been shown among institutionalised children with mental retardation (MR) [6–10]. Since institutionalised healthy subjects also display a higher prevalence of H. pylori infection [11,12], the present study investigated the seroprevalence of H. pylori infection among non‐institutionalised children with MR.…”

Section: Socio‐economic Features In Age‐ and Gender‐matched Children mentioning

confidence: 99%

High seroprevalence of Helicobacter pylori infection in non-institutionalised children with mental retardation

Luzza¹,

Concolino

Imeneo³

et al. 2004

Clinical Microbiology and Infection

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Eighty-four children with mental retardation (34 boys, 50 girls; age range 2-18 years, median 6 years) and 84 age- and gender-matched outpatient controls were studied. All children were living at home, had never stayed in an institution, and came from the same urban area. Seropositivity for Helicobacter pylori was found in 42 (50%) of 84 mentally retarded children and 16 (19%) of 84 controls (p < 0.01). Socio-economic factors did not differ between the two groups. The findings indicated that a higher prevalence of H. pylori infection occurs in children with mental retardation, regardless of whether they are institutionalised.

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Section: Socio‐economic Features In Age‐ and Gender‐matched Children mentioning

confidence: 99%

High seroprevalence of Helicobacter pylori infection in non-institutionalised children with mental retardation

Luzza¹,

Concolino

Imeneo³

et al. 2004

Clinical Microbiology and Infection

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“…Studies of H. pylori infection in institutionalized individuals with ID have consistently reported much higher rates of infection (60–90%) compared to matched groups in the general population (30–40%) (Berkowicz & Lee 1987; Lambert et al 1990; Proujansky et al 1994; Marshall 1994; Harris et al 1995; Bohmer et al 1997a; Lewindon et al 1997). Two‐fold higher rates of peptic ulcer disease and gastric cancer have been reported in institutionalized groups of adults with ID (Kim et al 1981; M. Duff, personal communication).…”

Section: Introductionmentioning

confidence: 99%

Environmental, medical, behavioural and disability factors associated with Helicobacter pylori infection in adults with intellectual disability

Wallace

Webb

Schluter

2002

J intellect Disabil Res

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In institutionalized adults with intellectual disability (ID), Helicobacter pylori infection occurs at approximately twice the rate it appears in the general population, and it may be responsible for the twofold higher rates of peptic ulcer disease and gastric cancer in this population. Medical, behavioural and additional environmental factors, as well as level of ID, may be related to the risk of infection with H. pylori. One hundred and sixty-eight adults with ID who were currently, had previously been or had never been institutionalized underwent a biopsychosocial evaluation. This included assessment of: level of ID using the Adaptive Behaviour Scale (ABS) Part I; levels of maladaptive behaviour using the ABS Part II; demographic, medical and environmental factors; as well as H. pylori tests using serology and faecal antigen. The overall rates of past or current infection with H. pylori in institutionalized and previously institutionalized participants were about twice that of the overall group of never-institutionalized participants, i.e. 87% and 79% compared to 44%, respectively (P < 0.001). The rates of H. pylori infection appeared to increase with age in the never-institutionalized group, but were consistently high across all ages in the other groups. The rate of infection was higher in those institutionalized for more than 5 years (95% versus 76%, P=0.02), in those with flatmates with excessive oral secretions (65% versus 21%, P < 0.001) or faecal incontinence (67% versus 27%, P < 0.001), and in those with more chronic illness and medications. All mean domain scores of the ABS Part I (Intellectual Disability) were significantly lower (indicating more severe ID) in the group currently infected with H. pylori compared to their non-infected counterparts. The majority of mean domain scores of the ABS Part II (Behaviour) were also worse, with half of these score differences reaching statistical significance in the currently infected group. The presence of alarm symptoms (e.g. vomiting, weight loss, haematemesis and melena), iron deficiency and body mass index were not significantly different in currently infected subjects. Adults with ID appear to be particularly at risk of infection with H. pylori. Environmental associations with infection include past or current institutionalization, a longer period of institutionalization, living with flatmates with excessive oral secretions and faecal incontinence. Medical associations include chronic disease and more medications, but not alarm symptoms or body mass index. Demographic associations may include increasing age in never-institutionalized adults, but no age effect in currently or previously institutionalized individuals. Psychosocial associations include more severe ID and maladaptive behaviour with current infection.

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“…Physically and mentally disabled children are particularly vulnerable to microorganisms because of their different feeding abilities, toilet needs, and sanitary arrangements. A high frequency of H. pylori infection has been shown among children with mental retardation (14)(15)(16)(17)(18)(19); however, there are no data regarding H. pylori infection in other metabolic diseases with mental retardation in the literature. Therefore, we evaluated the frequency of H. pylori infections among children with PKU.…”

mentioning

confidence: 99%

<i>Helicobacter pylori</i> Infection among Children with Phenylketonuria

2013

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SUMMARY: This study aimed to determine the frequency of Helicobacter pylori infections in children with phenylketonuria (PKU). Sixty-six children with PKU (35 boys, 31 girls; mean age, 8.2 ± 6.7 years) and 32 outpatient controls (15 boys, 17 girls; mean age, 9.6 ± 4.7 years) were studied. Socioeconomic factors did not differ between the two groups. The frequency of H. pylori infections was higher in patients with PKU (28.1z) than in healthy controls (9.4z). In particular, a higher frequency of infection was detected in patients with PKU with poor metabolic control (51.8z). The frequency of H. pylori infection in patients with PKU with good metabolic control was only 10.2z. There was no difference in the mean total WISC-R score between the poor and good metabolic control groups. A high frequency of H. pylori infection in children with PKU with poor metabolic control could be related to many factors. Advanced and standardized clinical studies on H. pylori infections in children with PKU are required.

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Symptomatic Helicobacter pylori infection in young patients with severe neurologic impairment

Cited by 24 publications

References 9 publications

High seroprevalence of Helicobacter pylori infection in non-institutionalised children with mental retardation

High seroprevalence of Helicobacter pylori infection in non-institutionalised children with mental retardation

Environmental, medical, behavioural and disability factors associated with Helicobacter pylori infection in adults with intellectual disability

<i>Helicobacter pylori</i> Infection among Children with Phenylketonuria

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