Symptomatic Hemorrhage Associated With Recurrent Pilocytic Astrocytoma With Granulation Tissue-Case Report-

Shingu, Takashi; Akiyama, Yasuhiko; Daisu, Mitsuhiro; Maruyama, Nobuyuki; Matsumoto, Yoshihisa; Miyazaki, Takeshi; Nagai, Hidemasa; Yamamoto, Yoshiaki; Yamasaki, Toshiki; Yoshida, Manabu; Maruyama, Riruke; Moritake, Kouzo

doi:10.2176/nmc.47.222

Cited by 8 publications

(5 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The histopathology revealed an organizing hematoma with some granulation tissue. [8] Some granulation tissue was seen in our case, but most of it was an organized hematoma. In the only other two patients that had nonaneurysmal hemorrhage after radiation for an optico-chiasmatic/hypothalamic glioma, 10 and 4 years after RT, respectively, the hemorrhage was asymptomatic and remote from the site of the tumor, in the temporal lobe.…”

Section: Discussionmentioning

confidence: 59%

See 1 more Smart Citation

Delayed hemorrhage after surgery and radiation in suprasellar pilocytic astrocytomas

2016

View full text Add to dashboard Cite

Delayed intracranial hemorrhage is a rare complication of treatment for central nervous system tumors. This may be secondary to malignant transformation of the tumor or vasculopathy related to radiation therapy (RT). While most reports on radiation-induced vasculopathy in children with optic pathway gliomas are associated with ischemic complications, there are only two reports of hemorrhagic complications in these patients. In both cases, the hemorrhage was asymptomatic and remote from the site of the original tumor but within the field of irradiation. We describe a female patient who underwent surgery for an optico-chiasmatic pilocytic astrocytoma (PA) at the age of 12 followed by RT at the age of 17 for tumor progression. The patient was followed with serial magnetic resonance imaging (MRI) scans showing marginal regression and no subsequent evidence of tumor recurrence, including the most recent MRI done only 6 months before the latest presentation. She then developed a symptomatic intratumoral hemorrhage at the age of 32 for which she underwent emergent surgery. To our knowledge, this is the first report of a nonaneurysmal-delayed hemorrhage within the site of previous surgery, several years after RT for a suprasellar PA. We review literature on delayed vasculopathy following the treatment of pediatric optic pathway gliomas and discuss the possible mechanisms of hemorrhage in our case. These long-term follow-up outcomes add significant insight and have implications in patient management.

show abstract

Section: Discussionmentioning

confidence: 59%

“…While a large hemorrhage causing sudden symptoms and signs may be rare, repeated microbleeds are common in PA since regressive alterations are well-known in these tumors. [8]…”

Section: Discussionmentioning

confidence: 99%

Delayed hemorrhage after surgery and radiation in suprasellar pilocytic astrocytomas

2016

View full text Add to dashboard Cite

show abstract

“…Lyons reported on a case of a spontaneous intracerebral hemorrhage in association with a pilocytic astrocytoma in a 75-year-old man [ 8 ]. Recurrent pilocytic astrocytomas are rare; however, recurrence associated with an intracerebral hemorrhage has been noted in the literature [ 10 ]. Another rare presentation of pilocytic astrocytomas has been reported in association with subarachnoid hemorrhage [ 1 , 4 ].…”

Section: Discussionmentioning

confidence: 99%

Hemorrhagic Pilocytic Astrocytomas in Adults: A Case Report and Literature Review

Galgano¹,

Padalino²,

Fullmer³

et al. 2016

Cureus

View full text Add to dashboard Cite

Pilocytic astrocytomas are histologically benign tumors, generally found in the pediatric population. Onset of symptoms is generally insidious, predominantly stemming from mass effect upon nearby structures. Patients harboring a pilocytic astrocytoma may present with gait disturbance, headaches, cranial nerve deficits, as well as hydrocephalus, depending on the exact location. Although cases of adult pilocytic astrocytomas in the adult population are described, they are quite uncommon. We present a case of an adult female presenting with acute neurological compromise resulting from an acutely hemorrhagic posterior fossa pilocytic astrocytoma. Her initial neurological assessment was consistent with a Glasgow coma scale of 4T, as the patient was experiencing decerebrate posturing. An emergent external ventricular drain was placed in the emergency department for acute hydrocephalus as a temporizing measure, prior to evacuation of the associated subdural and intratumoral hemorrhages, as well as resection of the mass. After a long hospital course and extensive rehabilitation, the patient made a remarkable recovery and eventually gave birth to a child via Caesarean section three years after her initial presentation.

show abstract

“…We aim to present the case of an adult harboring a posterior fossa pilocytic astrocytoma presenting in an acute fashion with a rapidly deteriorating neurological exam after spontaneous intratumoral hemorrhage. Cases of hemorrhagic presentation of these tumors have been reported in the literature [1][2][3][4][5][6][7][8][9][10][11], although they are quite rare. The vast majority of pilocytic astrocytomas are not associated with hemorrhage, leading one to infer that a small sub-population of these tumors may have inherent features making them more susceptible to hemorrhagic complications.…”

Section: Introductionmentioning

confidence: 99%

Acute Neurological Deterioration in an Adult with a Cerebellar Pilocytic Astrocytoma Accompanied by Intratumoral Hemorrhage, Subdural Hematoma, and Obstructive Hydrocephalus

Galgano¹,

Padalino²,

Fullmer³

et al. 2014

Cureus

View full text Add to dashboard Cite

Symptomatic Hemorrhage Associated With Recurrent Pilocytic Astrocytoma With Granulation Tissue-Case Report-

Cited by 8 publications

References 31 publications

Delayed hemorrhage after surgery and radiation in suprasellar pilocytic astrocytomas

Delayed hemorrhage after surgery and radiation in suprasellar pilocytic astrocytomas

Hemorrhagic Pilocytic Astrocytomas in Adults: A Case Report and Literature Review

Acute Neurological Deterioration in an Adult with a Cerebellar Pilocytic Astrocytoma Accompanied by Intratumoral Hemorrhage, Subdural Hematoma, and Obstructive Hydrocephalus

Contact Info

Product

Resources

About