Symptomatic management of neurodegenerative disease in the elderly

Oliver, David; Veronese, Simone

doi:10.1080/09699260.2016.1193968

Cited by 4 publications

(1 citation statement)

References 27 publications

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“…[4] CurrentN Dt herapies mainly consist of palliative treatments to reduce symptoms. [5,6] Thus, there is an urgent need to find effective drugs and explore other approaches for the treatment of NDs. In recent years, two parallel approaches have been developed.…”

Section: Introductionmentioning

confidence: 99%

Carnoquinolines Target Copper Dyshomeostasis, Aberrant Protein–Protein Interactions, and Oxidative Stress

Bellia

Grasso

Ahmed

et al. 2020

Chemistry A European J

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Metal dysregulation, oxidative stress, protein modification, and aggregation are factors strictly interrelated and associated with neurodegenerative pathologies. As such, all of these aspects represent valid targets to counteract neurodegeneration and, therefore, the development of metal‐binding compounds with other properties to combat multifactorial disorders is definitely on the rise. Herein, the synthesis and in‐depth analysis of the first hybrids of carnosine and 8‐hydroxyquinoline, carnoquinolines (CarHQs), which combine the properties of the dipeptide with those of 8‐hydroxyquinoline, are reported. CarHQs and their copper complexes were characterized through several techniques, such as ESI‐MS and NMR, UV/Vis, and circular dichroism spectroscopy. CarHQs can modulate self‐ and copper‐induced amyloid‐β aggregation. These hybrids combine the antioxidant activity of their parent compounds. Therefore, they can simultaneously scavenge free radicals and reactive carbonyl species, thanks to the phenolic group and imidazole ring. These results indicate that CarHQs are promising multifunctional candidates for neurodegenerative disorders and they are worthy of further studies.

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Section: Introductionmentioning

confidence: 99%