Symptomatic Radiation Pneumonitis After Stereotactic Body Radiation Therapy for Multiple Pulmonary Oligometastases or Synchronous Primary Lung Cancer

Kishi, Noriko; Matsuo, Yukinori; Yoneyama, Masahiro; Ueki, Kunikazu; Mizowaki, Takashi

doi:10.1016/j.adro.2022.100911

Cited by 1 publication

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References 31 publications

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“…Lung V5, V20, and MLD have been reported as risk factors for symptomatic pneumonitis after SBRT (32)(33)(34)(35)(36)(37). The difference in the irradiated volume in PBT compared with SBRT was larger for lung V5 than for lung V20, indicating that the larger the tumor size, the more PBT could reduce the irradiated volume with a lower dose (16).…”

Section: Discussionmentioning

confidence: 99%

Long-term Outcomes After Moderate Hypofractionated Proton Therapy for Centrally Located Non-small Cell Lung Cancer

et al. 2023

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Background/Aim: To investigate the outcomes of patients with centrally located non-small-cell lung cancer (NSCLC) treated with proton beam therapy (PBT) using moderate hypofractionation. Patients and Methods: Between 2006 and 2019, 34 patients with centrally located T1-T4N0M0 NSCLC who received moderate hypofractionated PBT were retrospectively reviewed. Results: The median follow-up was 50.8 months (range=5.8-100.4 months). The 3-year overall survival, progression-free survival (PFS), and local control rates were 70.4%, 55.5% and 80.5%, respectively. Grade 2 or 3 lung adverse events (AEs) after PBT were observed in five (14.7%) patients; however, grade 3 radiation pneumonitis was observed in one (2.9%) patient. Notably, no grade 4 or higher AEs were observed. Regarding the correlation between the lung dose and proximal bronchial tree maximum dose and grade 2 or higher lung AEs, a weak correlation was observed between the mean lung dose and AEs (p=0.035). Although the clinical target volume (CTV) was a risk factor for poor PFS, no significant correlation was found between the CTV and lung AEs after PBT. Conclusion: Moderate hypofractionated PBT may be a useful radiotherapy method for centrally located cT1-T4N0M0 NSCLC.

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