Symptomatic Rathke cleft cyst

Zhong, Weiying; You, Chao; Jiang, Shu; Huang, Suli; Chen, Haifeng; Liu, Jiagang; Zhou, Peizhi; Liu, Yi; Cai, Biao

doi:10.1016/j.jocn.2011.07.022

Cited by 34 publications

(24 citation statements)

References 29 publications

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“…However, these features were not effective for differential diagnosis. MRI signal intensity depends on the composition of the cyst, which may include protein, mucopolysaccharides, and cholesterol (23,24). Hence intensity is insufficient for making the diagnosis.…”

Section: Discussionmentioning

confidence: 99%

A New Perspective About Diagnosing Rathke’s Cleft Cyst: Localization of the Cyst in Reference to the Pituitary Gland

Fan

Luo

et al. 2017

Iran J Radiol

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Background: Rathke's cleft cysts (RCCs) were diagnosed mostly by shape, signal intensity and enhancement characteristics on MR images. Objectives: To identify the diagnosis of RCC by an improved understanding about the cyst's localization in reference to the pituitary gland. Patients and Methods:We retrospectively evaluated 124 patients with pituitary cystic lesions, verified surgically and histologically. The patients were divided into RCC and cystic pituitary adenoma (CPA) groups. The cysts in both groups were observed and compared, focusing on the shape and size, as well as clinical and MRI features, especially localization. Receiver-operating-characteristic (ROC) curve was performed with the clinical and MRI findings between the groups. Results: The RCC group included 90 patients (33 men) with a mean age of 40.9 years, while the CPA group included 34 patients (12 men) with a mean age of 43.5 years. On MRI, the RCCs were mostly located without shift of the pituitary stalk on the coronal view, with the superior margin of the cyst lying behind or across the junction point of the pituitary stalk on the sagittal view. The ROC curve was performed, and the following two variables exhibited good performances in diagnosing RCCs: the coronal localization (sensitivity, 91.1%; specificity, 79.4%; AUC = 0.853, 95% confidence interval: 0.778 -0.910, P < 0.0001), and the sagittal localization (sensitivity, 88.9%; specificity, 91.2%; AUC = 0.889, 95% confidence interval: 0.821 -0.939, P < 0.0001). Conclusion: Cyst localization, observed easily on MRI, can be used as an effective parameter for diagnosing RCC and distinguishing it from a CPA.

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Section: Discussionmentioning

confidence: 99%

A New Perspective About Diagnosing Rathke’s Cleft Cyst: Localization of the Cyst in Reference to the Pituitary Gland

Fan

Luo

et al. 2017

Iran J Radiol

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“…Typical symptoms associated with Rathke's cleft cysts are headache, endocrine dysfunction, and visual loss. 7,13,21 They tend to remain stable over time; only approximately 5.4% increase in size. 1,14 The pathogenesis of Rathke's cleft cysts is not clear, but the pattern of embryological formation of the hypothalamic-pituitary axis may play a major role in their development.…”

Section: Discussionmentioning

confidence: 99%

Rathke's cleft cysts in twins with Type 2C von Hippel-Lindau disease

Huff

Bonnin

Fulkerson

2014

PED

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Von Hippel-Lindau disease (VHLD) is characterized by a spectrum of benign and malignant tumors in the CNS and visceral organs. Rathke's cleft cysts are benign, nonneoplastic sellar lesions that are often asymptomatic. The authors report the case of twin sisters with VHLD Type 2C with radiographically similar sellar lesions. One twin required surgery for progressive visual loss. Pathological examination of resected tissue demonstrated Rathke's cleft cyst.

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“…An RCC most commonly involves both the sellar and suprasellar compartments, although it can be solely sellar or rarely solely suprasellar in location. 33,58 An RCC is commonly an incidental discovery on imaging or autopsy, although up to 3% to 9% of symptomatic sellar lesions are caused by RCCs. 33,58 A symptomatic RCC can present with headache, visual disturbances, or endocrine disorders from mass effect on surrounding structures.…”

Section: Rccmentioning

confidence: 99%

“…33,58 An RCC is commonly an incidental discovery on imaging or autopsy, although up to 3% to 9% of symptomatic sellar lesions are caused by RCCs. 33,58 A symptomatic RCC can present with headache, visual disturbances, or endocrine disorders from mass effect on surrounding structures. 33 Rarely, an RCC can present with apoplexy caused by intracystic hemorrhage.…”

Section: Rccmentioning

confidence: 99%