Symptomatic sensorineural hearing loss in patients with ulcerative colitis

Casella, Giovanni; Corbetta, Davide; Zolezzi, Monica; Bella, Camillo Di; Villanacci, Vincenzo; Salemme, Marianna; Milanesi, U.; Antonelli, Elisabetta; Baldini, Vittorio; Bassotti, Gabrio

doi:10.1007/s10151-015-1349-7

Cited by 11 publications

(4 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a retrospective study, SNHL was found in about 2% of patients with ulcerative colitis [137]. In these patients, OAE play a central role as they may indicate a cochlear involvement even when normal hearing thresholds are present [138].…”

Section: Inner Ear Involvement In Autoimmune Diseasesmentioning

confidence: 99%

Audiovestibular Symptoms in Systemic Autoimmune Diseases

Ralli

D’Aguanno

Stadio

et al. 2018

Journal of Immunology Research

View full text Add to dashboard Cite

Immune-mediated inner ear disease can be primary, when the autoimmune response is against the inner ear, or secondary. The latter is characterized by the involvement of the ear in the presence of systemic autoimmune conditions. Sensorineural hearing loss is the most common audiovestibular symptom associated with systemic autoimmune diseases, although conductive hearing impairment may also be present. Hearing loss may present in a sudden, slowly, rapidly progressive or fluctuating form, and is mostly bilateral and asymmetric. Hearing loss shows a good response to corticosteroid therapy that may lead to near-complete hearing restoration. Vestibular symptoms, tinnitus, and aural fullness can be found in patients with systemic autoimmune diseases; they often mimic primary inner ear disorders such as Menière's disease and mainly affect both ears simultaneously. Awareness of inner ear involvement in systemic autoimmune diseases is essential for the good response shown to appropriate treatment. However, it is often misdiagnosed due to variable clinical presentation, limited knowledge, sparse evidence, and lack of specific diagnostic tests. The aim of this review is to analyse available evidence, often only reported in the form of case reports due to the rarity of some of these conditions, of the different clinical presentations of audiological and vestibular symptoms in systemic autoimmune diseases.

show abstract

Section: Inner Ear Involvement In Autoimmune Diseasesmentioning

confidence: 99%

Audiovestibular Symptoms in Systemic Autoimmune Diseases

Ralli

D’Aguanno

Stadio

et al. 2018

Journal of Immunology Research

View full text Add to dashboard Cite

show abstract

“…Mice lacking Gzms exhibited a reduced immune tolerance and increased inflammation levels through a type I interferon-dependent pathway, leading to the development of autoimmune diseases, including diabetes (43,45) and ulcerative colitis (46). These two autoimmune diseases were further associated with SNHL (47,48). Gzmm was proposed to be downregulated in AIED, which was in accordance with the results of the current study.…”

Section: Discussionmentioning

confidence: 96%

Screening of genes associated with inﬂammatory responses in the endolymphatic sac reveals underlying mechanisms for autoimmune inner ear diseases

Zhang

Wang

2018

Exp Ther Med

View full text Add to dashboard Cite

The current study analyzed gene expression profiles of the endolymphatic sac (ES) in rats and identified expressed genes, present in the human and rat ES, to reveal key hubs for inflammatory responses. Microarray data (accession no. E-MEXP-3022) were obtained from the European Bioinformatics Institute database, including three biological replicates of ES plus dura tissues and three replicates of pure dura tissues form rats. Differentially expressed genes (DEGs) were screened using the Linear Model for Microarray data method and a protein-protein interaction (PPI) network was constructed using data from the Search Tool for the Retrieval of Interacting Genes/Proteins database followed by a module analysis via Clustering with Overlapping Neighborhood Expansion. Function enrichment analysis was performed using the Database for Annotation, Visualization and Integrated Discovery online tool. A total of 612 DEGs were identified, including 396 upregulated and 216 downregulated genes. Gene ontology term enrichment analysis indicated DEGs were associated with cell adhesion, including α5-integrin (Itga1) and secreted phosphoprotein 1 (Spp1); T cell co-stimulation, including C-C chemokine ligand (Ccl)21 and Ccl19; and the toll-like receptor signaling pathway, including toll-like receptor (Tlr)2, Tlr7 and Tlr8. These conclusions were supported by Kyoto Encyclopedia of Genes and Genomes pathway analyses revealing extracellular matrix-receptor interaction, including Itga1 and Spp1; leukocyte transendothelial migration, includingclaudin-4 (Cldn4); and malaria, including Tlr2. The hub roles of Itga1, Cd24 and Spp1 were revealed by calculating three topological properties of the PPI network. Ccl21, Ccl19 and Cldn4 were demonstrated to be crucial following significant module analysis according to the corresponding threshold, which revealed they were enriched in inflammation pathways. Tlr7, Tlr2, granzyme m and Tlr8 were common genes associated with inflammatory responses in rat and human ES. In conclusion, abnormal expression of the aforementioned inflammation-associated genes may be associated with the development of autoimmune inner ear diseases.

show abstract

“…As a result, a severe Th1 response and tissue damage occurs (20). SNHL in IBD patients can be in acute or silent form, or there may be periods of remission and exacerbations (9).…”

Section: Discussionmentioning

confidence: 99%

“…Hearing loss is acute and bilateral and occurs in a short period of weeks to months in the active period of the disease (4). In a few studies, significant levels of SNHL have been reported, especially in UC patients, but in some studies, these rates were found to be lower (7)(8)(9)(10). Therefore we aimed to determine the frequency of SNHL in patients with UC and CD and to evaluate the relationship between audiological features and clinical findings in IBD.…”

Section: Introductionmentioning

confidence: 98%

Ulcerative colitis may be a risk factor for sensorineural hearing loss

Yozgat

Gürler

2021

Journal of Health Sciences and Medicine

View full text Add to dashboard Cite

Introduction: Inner ear involvement of inflammatory bowel disease (IBD), which causes sensorineural hearing loss (SNHL) is acute and bilateral and arises in a short period of weeks to months in the active period of the disease. We aimed to determine the frequency of SNHL in patients with UC and CD and to evaluate the relationship between audiological features and clinical findings in IBD. Material and Method:The present study included 53 IBD patients and 20 healthy control patients who were followed up in the gastroenterology outpatient clinic of Abant Izzet Baysal University Hospital between January and May 2020 and accepted to participate in the study. Tympanometry, otoscopy, and audiometry examinations were performed. Results: There was no significant difference in terms of gender and age between the IBD and control groups. While there was no significant difference in air and bone conduction in both ears in patients with CD, there was a significant difference between both conductions in UC (p: 0.0001 in the left ear, p: 0.004 in the right ear). SNHL was detected in 45.2% (n:14) of UC patients and 13.6% (n:3) of CD patients in audiometry. Three of our UC patients had moderate, one had moderately severe, and one had profound hearing loss. Conclusion: SNHL has been detected in a significant number of UC patients. Also, the hearing functions deteriorate significantly as the age of the patients and the duration of the disease increases. UC patients with a long-term disease or older patients should be evaluated for SNHL.

show abstract

Symptomatic sensorineural hearing loss in patients with ulcerative colitis

Abstract: In our series, sensorineural hearing loss was found in less than 2 % of adult patients with ulcerative colitis evaluated in a department of otolaryngology. Systematic evaluation for this extraintestinal manifestation should not be carried out unless hearing loss is present.

Cited by 11 publications

References 23 publications

Audiovestibular Symptoms in Systemic Autoimmune Diseases

Audiovestibular Symptoms in Systemic Autoimmune Diseases

Screening of genes associated with inﬂammatory responses in the endolymphatic sac reveals underlying mechanisms for autoimmune inner ear diseases

Ulcerative colitis may be a risk factor for sensorineural hearing loss

Contact Info

Product

Resources

About