Symptomatic Thrombosis in Turkish Neonates

Gürgey, Aytemiz; Tekinalp, Gülsevin; Cinar, Asli; Çakmak, Fatmanur

doi:10.1097/00043426-200407000-00003

Cited by 8 publications

(8 citation statements)

References 18 publications

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“…Male sex is proposed as a risk factor, with more embolization occurring in males than females [6,7,10,[12][13][14]28,29,[46][47][48][49][50][51], but this is inconsistent across studies [35]. Of the 83 reported cases, 19 newborns were female (23%), 24 were male (29%), and in 40 (48%) the sex was unspecified.…”

Section: Congenital Risk Factorsmentioning

confidence: 99%

Spontaneous neonatal arterial thromboembolism

Rashish

Paes²,

Nagel³

et al. 2013

Blood Coagulation &Amp; Fibrinolysis

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Neonatal spontaneous arterial thromboembolism is a rare phenomenon with a high risk of morbidity and mortality. Currently, there is little information regarding common risk factors, diagnostic strategies, therapeutic interventions, and outcomes of this condition. The objective was to nucleate the best evidence regarding the disorder in order to facilitate early detection and treatment recommendations and document adverse outcomes. Web of Science, PubMed, Medline, CINAHL, Cochrane Databases, DARE, and OVID databases were searched using the following keywords: 'arterial' AND 'thrombus' OR 'thrombosis' OR 'thromboembolism' OR 'embolism' AND 'spontaneous' AND 'at birth' OR 'newborn' OR 'neonatal' OR 'fetal' AND 'umbilical cord' OR 'umbilical wall necrosis' AND 'coagulation abnormality' OR 'placenta bits' OR 'ischemic limbs'. The search yielded 172 articles, all of which were case series or single case descriptions. Twenty-seven met inclusion criteria, with a total of 53 newborns and 30 newborn pathology reports. Ultrasound was the preferred method of diagnosis and thromboembolic locations varied with the most common site being umbilical, resulting in embolism and vascular compromise. Treatment interventions and drug dosages were not standardized and ranged from use of anticoagulants to surgery and hyperbaric oxygen. The reported mortality rate was 32.8%. Recurring etiological features facilitated identification of possible sequences of events contributing to the disorder. The literature lacks empirical evidence to affirm causes and predisposing risk factors for timely diagnosis and effective treatment of spontaneous neonatal arterial thromboembolism. Further research is needed to clearly establish the causes and the efficacy of specific treatment options.

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Section: Congenital Risk Factorsmentioning

confidence: 99%

Spontaneous neonatal arterial thromboembolism

Rashish

Paes²,

Nagel³

et al. 2013

Blood Coagulation &Amp; Fibrinolysis

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“…Various risk factors for thrombosis in newborns have been reported in the literature. In a study by Gurgey and colleagues [32], which consisted of 26 newborns with thrombosis, patients with an infection were largest group, and those with hypoxia were the second-largest group. Another study by Nowak-Gottl and colleagues [31], which consisted of 79 newborns with thrombosis, showed that the largest patient groups had a central venous catheter, spontaneous thrombosis, and infection, respectively.…”

Section: Incidence Of Thrombosismentioning

confidence: 99%

INCIDENCE OF AND RISK FACTORS FOR CHILDHOOD THROMBOSIS: A Single-Center Experience in Ankara, Turkey

Özbek

Alioğlu

Avcı

et al. 2009

Pediatric Hematology and Oncology

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This study was conducted to analyze the incidence of and risk for thrombosis in thrombotic children monitored in the Department of Pediatric Hematology of our hospital at the time of diagnosis, in addition to the clinical characteristics of those patients. The clinical and laboratory findings of 122 patients diagnosed with thrombosis from 1997 to 2006 were retrospectively analyzed. The incidence of thrombosis was 88.6/10,000 hospital admissions. The authors found that 31.1% of the patients studied had a thrombosis in more than 1 region. The incidence of thrombosis by anatomic site was as follows: 42 thromboses in the peripheral arterial system, 39 in an intracardiac region, 38 in the abdominal venous system, 36 in the deep peripheral venous system, and 28 in the cerebral vascular system. The mean age of the patients at the time of diagnosis was 4.9 years. Of the patients studied, 10.7% were neonates, 35.3% were infants younger than 1 year, and 48.4% were younger than 2 years. Most of the patients had a congenital cardiac disease and spontaneous thrombosis, and 66.1% had at least 1 acquired risk factor, the most common of which were having undergone surgery (42%) or wearing a central venous catheter (39%). A hereditary factor for the development of thrombosis was present in 54% of the patients. The most frequently observed hereditary risk factor was the MTHFR 677C-T mutation, and the second most common was the factor V Leiden mutation. Thrombosis should be considered a systemic disorder, and thrombotic patients should be evaluated with appropriate methods. Acquired and hereditary risk factors should be analyzed systematically in thrombotic patients.

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“…The congenital prothrombotic disorders that have been linked to TEs in newborns include deficiencies of antithrombin, protein C, protein S and plasminogen and the presence of prothrombin gene 20210A and Factor V Leiden. 3 The methylene tetrahydrofolate reductase (MTHFR) C677T genotype found in our patient has been positively associated with arterial and venous thrombotic disease in some populations; however, this mutation alone may not sufficiently explain this arterial clot. 4,5 The use of HBOT has been shown by several investigators to restore a favorable cellular environment for wound healing and support vascular proliferation by increasing the oxygen content of the plasma.…”

Section: Case Presentationmentioning

confidence: 73%

Hyperbaric oxygen in treatment of neonatal arterial thromboembolism of lower extremities

et al. 2006

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Arterial thromboembolism (TE) in the absence of current or recent history of a central catheter is a rare condition in newborn period. We report a case of severe lower extremities arterial TE of unclear etiology in a full-term neonate. By adding hyperbaric oxygenation to thrombolytic and antithrombotic therapy, we achieved improved perfusion of the upper leg tissues, preserving the knee and enabling below-the-knee amputation.

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Symptomatic Thrombosis in Turkish Neonates

Cited by 8 publications

References 18 publications

Spontaneous neonatal arterial thromboembolism

Spontaneous neonatal arterial thromboembolism

INCIDENCE OF AND RISK FACTORS FOR CHILDHOOD THROMBOSIS: A Single-Center Experience in Ankara, Turkey

Hyperbaric oxygen in treatment of neonatal arterial thromboembolism of lower extremities

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