Symptomatology and Clinic of Hydronephrosis Associated With Uretero Pelvic Junction Anomalies

Bilge, İlmay

doi:10.3389/fped.2020.00520

Cited by 8 publications

(3 citation statements)

References 72 publications

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“…Ureteropelvic junction obstruction (UPJO), classified as congenital anomalies of the kidney and urinary tract (CAKUT) with an obstructive pattern, constitutes the most important etiology of hydronephrosis and also one of the common causes of chronic kidney disease (CKD) in children. Severe UPJO is associated with obstruction to urine flow from the renal pelvis to the ureter and can result in ultimately complete loss of the involved kidney [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

Exacerbation of Congenital Hydronephrosis as the First Presentation of COVID-19 Infection in Children

Mohkam

Jamee

Kompani

et al. 2022

Case Reports in Nephrology

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Background. Congenital hydronephrosis is one of the most common abnormalities of the upper urinary tract, which can be exacerbated by a variety of intrinsic or extrinsic triggers. The urinary tract system is one of the major organs complicated by COVID-19 infection. Case Presentations. Here, we report five patients with an established diagnosis of congenital hydronephrosis, who presented with acute abdominal pain and fever and an abrupt increase in the anteroposterior pelvic diameter (APD). Patients had a previous stable course and were under regular follow-up with serial ultrasonographic studies. They underwent surgery or supportive treatment due to the later exacerbation of hydronephrosis. Based on the clinical and imaging findings, no plausible etiologies for these exacerbation episodes, including infection, nephrolithiasis, or abdominal masses, could be postulated. The common aspect in all these patients was the evidence of a COVID-19 infection. Conclusions. Infection with COVID-19 in children with antenatal hydronephrosis may exacerbate the degree of hydronephrosis and renal APD in ultrasonography, which itself may be mediated by the increase in inflammatory mediators.

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Section: Discussionmentioning

confidence: 99%

Exacerbation of Congenital Hydronephrosis as the First Presentation of COVID-19 Infection in Children

Mohkam

Jamee

Kompani

et al. 2022

Case Reports in Nephrology

View full text Add to dashboard Cite

show abstract

“…Ureteropelvic junction obstruction (UPJO), classi ed as congenital anomalies of the kidney and urinary tract (CAKUT) with an obstructive pattern, constitutes the most important etiology of hydronephrosis and also one of the common causes of chronic kidney disease (CKD) in children. Severe UPJO is associated with obstruction to urine ow from the renal pelvis to the ureter and can result in ultimately complete loss of the involved kidney [9].…”

Section: Discussionmentioning

confidence: 99%

Exacerbation of Congenital Hydronephrosis as the First Presentation of COVID-19 Infection in Children: A Case Series

Mohkam

Jamee

Kompani

et al. 2021

Preprint

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Background:Congenital hydronephrosis is one of the most common abnormalities of the upper urinary tract, which can be exacerbated by a variety of intrinsic or extrinsic triggers. The urinary tract system is one of the major organs complicated by COVID-19 infection. Case presentations:Here we report five patients with an established diagnosis of congenital hydronephrosis, who presented with acute abdominal pain and fever and an abrupt increase in the anteroposterior pelvic diameter (APD). Patients had a previous stable course and were under regular follow-up with serial ultra-sonographic studies. They underwent surgery or supportive treatment due to the later exacerbation of hydronephrosis. Based on the clinical and imaging findings, no plausible etiologies for these exacerbation episodes, including infection, nephrolithiasis or abdominal masses, could be postulated. The common aspect in all these patients was the evidence of a COVID-19 infection. Conclusions:Infection with COVID-19 in children with antenatal hydronephrosis may exacerbate the degree of hydronephrosis and renal APD in ultrasonography, which itself may be mediated by the increase in inflammatory mediators.

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“…In the context of symptomatology of UPJO, pain response, correlated with the extent of pyelocaliceal system dilatation, is relatively rare, particularly among younger children [8]. On the contrary, in older children with hydronephrosis the pain in the lumbar or midabdominal region occurs more frequently.…”

Section: Introductionmentioning

confidence: 99%

Interstitial Cells of Cajal and P2X3 Receptors at Ureteropelvic Junction Obstruction and Their Relationship with Pain Response

Borselle,

Kaczorowski,

Gogolok

et al. 2024

JCM

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Introduction: Etiopathogenesis and the symptomatology of ureteropelvic junction obstruction (UPJO) in the pediatric population has not yet been definitely clarified, suggesting a multifactorial nature of the condition. The aim was to analyze the association between the number of Interstitial Cells of Cajal (ICCs), as well as P2X3 receptors in ureteropelvic junction (UPJ) and the pain response in pediatric patients with hydronephrosis. Methods: 50 patients with congenital hydronephrosis underwent open or laparoscopic pyeloplasty at one of two departments of pediatric surgery and urology in Poland. Patients were divided into two groups according to the pain symptoms before surgery. A total of 50 samples of UPJ were obtained intraoperatively and underwent histopathological and immunohistochemical (IHC) analysis. Quantitative assessment of ICCs was based on the number of CD117(+) cells of adequate morphology in the subepithelial layer and the muscularis propria. Expression of P2X3 receptors was evaluated as the intensity of IHC staining. Results: Patients with hydronephrosis and accompanying pain were on average 60 months older (77 vs. 17 months) than children with asymptomatic hydronephrosis (p = 0.017). Symptomatic children revealed higher numbers of ICCs in both the subepithelial layer and in the lamina muscularis propria. In particular, symptomatic patients aged 2 years or more exhibited significantly higher numbers of ICCs in the subepithelial layer. Significant differences in the distribution of ICCs between the subepithelial layer and the lamina muscularis propria were observed in both groups. Expression of P2X3 receptors was limited to the urothelium and the muscle layer and correlated between these structures. There was no relationship between pain response and the expression of P2X3 receptors. Conclusions: ICCs and P2X3 receptors may participate in the pathogenesis of UPJO and in the modulation of pain response to a dilatation of the pyelocaliceal system. Explanation of the role of ICCs and P2X3 receptors in propagation of ureteral peristaltic wave and the modulation of pain stimuli requires further studies.

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Symptomatology and Clinic of Hydronephrosis Associated With Uretero Pelvic Junction Anomalies

Cited by 8 publications

References 72 publications

Exacerbation of Congenital Hydronephrosis as the First Presentation of COVID-19 Infection in Children

Exacerbation of Congenital Hydronephrosis as the First Presentation of COVID-19 Infection in Children

Exacerbation of Congenital Hydronephrosis as the First Presentation of COVID-19 Infection in Children: A Case Series

Interstitial Cells of Cajal and P2X3 Receptors at Ureteropelvic Junction Obstruction and Their Relationship with Pain Response

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