Symptoms and Pathophysiological Correlations in Patients with Constipation and Functional Dyspepsia

Abstract

Introduction: Patients with constipation often report dyspeptic symptoms, but whether constipation is associated with specific dyspeptic symptoms and altered gastrointestinal (GI) motility, remains to be established. Our aim was to study symptoms association and GI motility parameters in patients with constipation and functional dyspepsia. Patients and Method: 42 patients with different symptoms and severity of constipation and dyspepsia were enrolled. Scintigraphic gastric emptying, colonic transit time and gallbladder contraction were studied in all subjects. Results: No significant association was observed between individual symptoms of constipation and dyspepsia. Patients with more severe constipation did not have higher dyspepsia severity scores. Colonic transit time, gastric half emptying and gallbladder contraction were not significantly correlated. Although patients with severe nausea had faster colonic transit than those with absent/mild symptom (19 ± 2 vs. 48 ± 7 h; p < 0.05), the multivariate analysis only revealed a significant association between severe postprandial fullness, delayed t_1/2 (OR 1.05, CI 1–1.1) and impaired gallbladder contraction (OR 0.94, CI 0.89–0.99). Conclusions: Constipation was not associated with severity, or any particular dyspeptic symptom. Although motor abnormalities of both colon and proximal GI tract regions existed in the subset of constipated dyspeptic patients, they did not seem associated with the genesis of different dyspeptic symptoms.

Thermal Care of Functional Dyspepsia Based on Bicarbonate‐Sulphate‐Calcium Water: A Sequential Clinical Trial

“…Thermal water and care has no significant effects on heartburn and the abdominal syndrome ( Fig. 6 ), suggesting a specific effect of therapy at the gastroduodenal level and the possibility of different mechanisms for therapies targeted at the esophageal and abdominal walls ( 36 – 39 ).…”

Pharmacokinetic study of the prokinetic compounds meranzin hydrate and ferulic acid following oral administration of Chaihu-Shugan-San to patients with functional dyspepsia

“…Functional dyspepsia (FD) refers to postprandial fullness and early satiation that are thought to be the results of dysfunctional gastrointestinal motility (Sarnelli et al, 2003(Sarnelli et al, , 2005. The high incidence (10-20%) (Olafsdottir et al, 2010) of FD is a burden to the economy and quality of life for people worldwide (Talley, 1996(Talley, , 2008.…”