Symptoms and quality of life in HIV-infected patients with benign prostatic hyperplasia are improved by the consumption of a newly developed whole tomato-based food supplement. A phase II prospective, randomized double-blinded, placebo-controlled study

Quirós-Roldán, Eugenia; Carriero, Canio; Paghera, Simone; Antoni, Melania Degli; Fiorini, Chiara; Quaresima, Virginia; Castelli, Francesco

doi:10.1016/j.jff.2021.104495

Cited by 3 publications

(2 citation statements)

References 62 publications

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“…In view of the fact that metabolic syndrome and chronic inflammation, both considered to be risk factors for BHP, are frequently observed in HIV-infected patients [ 90 ] (in whom PCa incidence is expected to increase in the near future [ 91 ]), a validation study was performed on HIV+ patients with BPH using the treatment schedule. Additionally, in this trial, the daily WTFS consumption resulted in a significant amelioration in LUTSs, quality of life, free/total PSA ratio, and diastolic blood pressure, with a trend in the decrease in the IL-6 serum level [ 92 ].…”

Section: Tomato and Olive Oil In Prostate Healthmentioning

confidence: 99%

Improving Whole Tomato Transformation for Prostate Health: Benign Prostate Hypertrophy as an Exploratory Model

Natali

Piantelli

Minacori

et al. 2023

IJMS

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It is well-established that the beneficial properties of single phytonutrients can be better attained when they are taken with the complex of the molecules present in their natural milieu. Tomato, the fruit providing the most comprehensive complex of prostate-health-preserving micronutrients, has been shown to be superior to its single-nutrient counterparts in decreasing the incidence of age-related prostate diseases. Herein, we describe a novel tomato food supplement enriched with olive polyphenols, containing cis-lycopene concentrations far exceeding those present in industry-produced tomato commodities. The supplement, endowed with antioxidant activity comparable to that of N-acetylcysteine, significantly reduced, in experimental animals, the blood levels of prostate-cancer-promoting cytokines. In prospective, randomized, double-blinded, placebo-controlled studies performed on patients affected by benign prostatic hyperplasia, its uptake significantly improved urinary symptoms and quality of life. Therefore, this supplement can complement and, in some cases, be an alternative to current benign prostatic hyperplasia management. Furthermore, the product suppressed carcinogenesis in the TRAMP mouse model of human prostate cancer and interfered with prostate cancer molecular signaling. Thus, it may offer a step forward in exploring the potential of tomato consumption to delay or prevent the onset of age-related prostate diseases in high-risk individuals.

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Section: Tomato and Olive Oil In Prostate Healthmentioning

confidence: 99%

Improving Whole Tomato Transformation for Prostate Health: Benign Prostate Hypertrophy as an Exploratory Model

Natali

Piantelli

Minacori

et al. 2023

IJMS

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“…These effects are associated with significant reductions in the levels of some proinflammatory and proangiogenic cytokines such as VEGF and IL-6 (Pannellini et al, 2010). Furthermore, clinical training and validation trials have shown that WTBFS significantly relieves urinary symptoms and improves the quality of life of patients suffering from benign prostatic enlargement (Cormio et al, 2021; Quiros-Roldan et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Development of the whole tomato and olive-based food supplement enriched with anti-platelet aggregating nutrients

et al. 2022

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Background Platelet dysfunctions are shared by cardiovascular diseases and a wide range of inflammatory diseases. Aims To determine the ability of a new whole tomato-based food supplement (WTBFS) containing carotenoid and olive polyphenols to inhibit platelet aggregation. Methods Aggregation was evaluated in platelet-rich plasma using microtiter plates and a plate reader. Results Platelets treated with WTBFS showed a >70% reduction of 5 µM adenosine diphosphate (ADP)-induced platelet aggregation; at 10 µM of ADP, the inhibitory effect of WTBFS was reduced of about 50%. Similarly, 78% and 48% reduction were obtained using 5 µg/mL and 10 µg /mL of collagen as an agonist Conclusion Since the compounds in WTBFS share the ability to inhibit STAT3, the inhibition of its signaling pathway may represent the mechanism underlying the antiplatelet activities. The activity of a lipophilic solution prepared from WTBS was in vitro tested on the platelet aggregation in response to ADP agonists and Collagen.

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Exploring natural herbs: their role in treating male infertility, enhancing sexual desire and addressing urological disorders

Nasir,

Yabalak

2024

International Journal of Environmental Health Research

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Symptoms and quality of life in HIV-infected patients with benign prostatic hyperplasia are improved by the consumption of a newly developed whole tomato-based food supplement. A phase II prospective, randomized double-blinded, placebo-controlled study

Cited by 3 publications

References 62 publications

Improving Whole Tomato Transformation for Prostate Health: Benign Prostate Hypertrophy as an Exploratory Model

Improving Whole Tomato Transformation for Prostate Health: Benign Prostate Hypertrophy as an Exploratory Model

Development of the whole tomato and olive-based food supplement enriched with anti-platelet aggregating nutrients

Exploring natural herbs: their role in treating male infertility, enhancing sexual desire and addressing urological disorders

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