Symptoms during chemotherapy in colorectal cancer patients

Röhrl, Kari; Guren, Marianne G.; Småstuen, Milada Cvancarova; Rustøen, Tone

doi:10.1007/s00520-018-4598-y

Cited by 37 publications

(35 citation statements)

References 36 publications

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“…18 In a study of 120 patients with colorectal cancer that completed PROMs for symptom burden, the severity score for worrying and lack of energy was significantly higher in women compared with men. 19 Similarly, in a cohort of more than 400 patients with melanoma, female patients reported significantly more anxiety over a 2-year prospective follow-up assessment period compared with male patients. 20 In a population of patients with advanced cancer, including lung, pancreatic or oesophageal tumours, male sex predicted a better emotional wellbeing, assessed by the Functional Assessment of Cancer Therapy questionnaire (FACT-G).…”

Section: Pros In Oncologymentioning

confidence: 96%

Sex-specific and gender-specific aspects in patient-reported outcomes

et al. 2020

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Patient-reported outcomes (PROs) are important tools in patient-centred medicine and allow for individual assessment of symptom burden and aspects of patients’ quality of life. While sex and gender differences have emerged in preclinical and clinical medicine, these differences are not adequately represented in the development and use of patient-reported outcome measures. However, even in personalised approaches, undesirable biases may occur when samples are unbalanced for certain characteristics, such as sex or gender. This review summarises the current status of the literature and trends in PROs with a focus on sex and gender aspects.

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Section: Pros In Oncologymentioning

confidence: 96%

Sex-specific and gender-specific aspects in patient-reported outcomes

et al. 2020

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“…Although they adapt and learn to live with the problems in daily life, neurotoxicity can cause irritation, anger, and fatigue. In a previous study of Röhrl et al, the results show that lack of energy was the most occurring symptom post‐chemotherapy in patients with CRC.…”

Section: Discussionmentioning

confidence: 83%

Sense of coherence and health‐related quality of life in patients with neurotoxicity after cancer chemotherapy: Assessment from a real‐time mobile phone–based system

et al. 2019

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Objective: In the present study, we aimed to assess sense of coherence (SOC) andhealth-related quality of life (HRQOL) during and after adjuvant chemotherapy by mobile phone-based reporting in patients with colorectal cancer experiencing neurotoxicity. Methods:In this prospective descriptive cohort study, a mobile phone-based system was used to receive a series of real-time longitudinal patient-reported assessments of SOC (13-item), HRQOL (Functional Assessment of Cancer Therapy-General (FACT-G) 27-item), and neurotoxicity (OANQ 29-item) from 43 patients with colorectal cancer after being treated with chemotherapy including oxaliplatin. Measurements were conducted during the whole treatment period (mean 5 cycles) and up to 12 months after completing chemotherapy. Results:In total, 817 questionnaire responses (226 SOC, 221 FACT-G, 370 OANQ) answered during and after chemotherapy treatment were available for analysis. Even though all patients experienced neurotoxicity during the treatment period, HRQOL was stable over time. Over time, the ratings of physical wellbeing tended to increase, while the subscale of social wellbeing tended to decrease. Overall SOC, including the three components comprehensibility, manageability, and meaningfulness was stable during the entire study period. No internal data was missing due to the mobile phone-based system. Conclusions: All patients had neurotoxicity during the treatment period that seemed to affect the social wellbeing component of HRQOL, but SOC seemed unaffected. Real-time patient-reported assessment using mobile phone technology could be valuable in the clinical setting to provide continuous individualised monitoring to help identify patients who need further evaluation to maintain or improve their psychosocial health. Occupation Type of cancer location, n (%)Colon 38 (88) Rectum 5 (12) Chemotherapy, n (%) FOLFOX 2 6 (14) CAPOX 3 37 (86) Oxaliplatin mg (total dose) mean, (range) 918, (120-1680) 1 Sex distribution in follow-up male/female; 3 months (55 %/45 %), 6 months (50 %/50 %), 9 months (40 %/60 %) and 12 months (46 %/54 %). 2 Fluorouracil + leucovorin + oxaliplatin. 3 Capecitabine + oxaliplatin. 4Dose reduction was applied to all patients at some point, mean 5 OXAtreatments.

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“…Where used chemotherapy to cure cancer started with many attempts to establish new methods for evaluating the chemical effect in rodents by using transplantable different tumors [33]. Nowadays, this is also referred to as anti-tumor or anti-neoplastic drugs that may be administered for a curative purpose or it may be directed at minimizing symptoms (palliative chemotherapy) [34]. Chemotherapy can be seen to a huge extent as a means of destroying or disrupting cancer cells, which can then result in the death of cells (apoptosis) [35].…”

Section: Chemotherapy Trialsmentioning

confidence: 99%

Recent investigations into synthesis and pharmacological activities of phenoxy acetamide and its derivatives (chalcone, indole and quinoline) as possible therapeutic candidates

2021

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Graphical abstract Medicinal chemistry can rightfully be regarded as a cornerstone in the public health of our modern society that combines chemistry and pharmacology with the aim of designing and developing new pharmaceutical compounds. For this purpose, many chemical techniques as well as new computational chemistry applications are used to study the utilization of drugs and their biological effects. In the biological interface, medicinal chemistry constitutes a group of interdisciplinary sciences, as well as controlling its organic, physical and computational pillars. Therefore, medicinal chemists working to design an integrated and developing system that portends an era of novel and safe tailored drugs either by synthesizing new pharmaceuticals or to improving the processes by which existing pharmaceuticals are made. It includes researching the effects of synthetic, semi-synthetic and natural biologically active substances based on molecular interactions in terms of molecular structure with triggered functional groups or the specific physicochemical properties. The present work focuses on the literature survey of chemical diversity of phenoxy acetamide and its derivatives (Chalcone, Indole and Quinoline) in the molecular framework in order to get complete information regarding pharmacologically interesting compounds of widely different composition. From a biological and industrial point of view, this literature review may provide an opportunity for the chemists to design new derivatives of phenoxy acetamide and its derivatives that proved to be the successful agent in view of safety and efficacy to enhance life quality.

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Symptoms during chemotherapy in colorectal cancer patients

Cited by 37 publications

References 36 publications

Sex-specific and gender-specific aspects in patient-reported outcomes

Sex-specific and gender-specific aspects in patient-reported outcomes

Sense of coherence and health‐related quality of life in patients with neurotoxicity after cancer chemotherapy: Assessment from a real‐time mobile phone–based system

Recent investigations into synthesis and pharmacological activities of phenoxy acetamide and its derivatives (chalcone, indole and quinoline) as possible therapeutic candidates

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