Symptoms-modifying effects of electromotive administration of glucosamine sulphate among patients with knee osteoarthritis

Abstract

Background: Most trials on symptom-modifying effects of glucosamine are limited to administration through oral route with dearth of empirical data on the use of electromotive force. Objective: The study determined the effects of glucosamine sulphate (GS) iontophoresis (IoT) on radiographic parameters of patients with knee osteoarthritis (OA). Methods: Fifty-three patients were randomly assigned to three groups. About 1[Formula: see text]g each of GS was administered using IoT and cross-friction massage (CFM) for participants in groups 1 (IoT) and 2 (CFM), respectively. Group 3 ((Combined therapy) CoT) received 1[Formula: see text]g of GS using both IoT and CFM. Interventions were twice a week for 12 weeks. Analysis of variance (ANOVA) was used to analyze the data ([Formula: see text]). Results: After 12 weeks, the medial joint space width (JSW) of the CFM group was significantly higher than that of IoT and CoT groups ([Formula: see text] and [Formula: see text]). Lateral JSW of IoT group was significantly higher than both CFM ([Formula: see text]) and CoT groups ([Formula: see text]). There were significant decreases in pain intensities; increase in knee flexion and physical functions across the groups ([Formula: see text]; [Formula: see text], respectively). Conclusion: It was concluded that there were significant decreases in the degenerative changes at the knee joint.

Evaluation of the Effectiveness of Iontophoresis with Perskindol Gel in Patients with Osteoarthritis of the Knee Joints

“…The ions of the substance penetrate the skin through the path of least resistance, i.e., mainly through the sweat glands. It should be emphasized that the advantage of iontophoresis is the fact that a high concentration of the drug can be obtained in the target tissue without the need for oral administration, resulting in a reduced risk of overdose and side effects [ 8 , 13 , 14 , 15 ].…”

Multifaceted Protective Role of Glucosamine against Osteoarthritis: Review of Its Molecular Mechanisms

“…Glucosamine (175 mg/kg) in combination with chondroitin sulphate (140 mg/kg) reduces joint degeneration in rats with knee OA induced by anterior cruciate ligament transection after 3 months [36]. The positive effects of glucosamine on patients with OA have been established in numerous clinical trials [37][38][39][40][41][42][43][44][45]. Glucosamine decreases pain, enhances joint function and mobility, and reduces cartilage deterioration in patients with OA [38].…”

“…The positive effects of glucosamine on patients with OA have been established in numerous clinical trials [37][38][39][40][41][42][43][44][45]. Glucosamine decreases pain, enhances joint function and mobility, and reduces cartilage deterioration in patients with OA [38]. For instance, glucosamine supplementation for 2 years and 6 months has reduced the risk of radiographic knee OA by preventing the narrowing of joint spaces [40].…”

Non-pharmacologic supplementation as an adjunct treatment for osteoarthritis

“…Recently, increasing number of studies examined the e®ect of potential adjunct supplementation used in musculoskeletal conditions such as improving muscle strength in frail elderly, 8 and reducing joint pain in people with osteoarthritis. 9 In this issue of Hong Kong Physiotherapy Journal, two studies investigated the e®ectiveness of non-pharmacologic supplementation for managing symptoms of osteoarthritic knee 10 and hip. 11 Oninbinde et al 10 compared the e®ect of topical administration of glucosamine sulphate via 3 methods, i.e.…”

“…9 In this issue of Hong Kong Physiotherapy Journal, two studies investigated the e®ectiveness of non-pharmacologic supplementation for managing symptoms of osteoarthritic knee 10 and hip. 11 Oninbinde et al 10 compared the e®ect of topical administration of glucosamine sulphate via 3 methods, i.e. (1) iontophoresis (IoT), (2) cross-friction massage (CFM) and (3) combined therapy of IoT and CFM (CoT) on pain intensity, joint space width, range of motion and physical function in people with osteoarthritic knee.…”