Symptoms of atopic dermatitis are influenced by outdoor air pollution

Kim, Jihyun; Kim, Eunhye; Oh, Inbo; Jung, Kyomin; Han, Youngshin; Cheong, Hae-Kwan; Ahn, Kangmo

doi:10.1016/j.jaci.2013.04.019

Cited by 173 publications

(157 citation statements)

References 9 publications

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“…A South Korean study of 41 children aged 8-12 years collected symptom diaries for 67 days and found significant associations between pruritus severity and daily ambient PM concentrations [103]. A longer term study of 22 Korean children using symptom diaries for 18 months also found associations of AD symptoms with levels of outdoor air pollutants [104].…”

Section: Air Pollutantsmentioning

confidence: 99%

Environmental risk factors and their role in the management of atopic dermatitis

Kantor

Silverberg

2016

Expert Review of Clinical Immunology

278

225

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Introduction-The etiology of atopic dermatitis (AD) is multifactorial with interaction between genetics, immune and environmental factors.Areas covered-We review the role of prenatal exposures, irritants and pruritogens, pathogens, climate factors, including temperature, humidity, ultraviolet radiation, outdoor and indoor air pollutants, tobacco smoke exposure, water hardness, urban vs. rural living, diet, breastfeeding, probiotics and prebiotics on AD.Expert commentary-The increased global prevalence of AD cannot be attributed to genetics alone, suggesting that evolving environmental exposures may trigger and/or flare disease in predisposed individuals. There is a complex interplay between different environmental factors, including individual use of personal care products and exposure to climate, pollution, food and other exogenous factors. Understanding these complex risk factors is crucial to developing targeted interventions to prevent the disease in millions. Moreover, patients require counseling on optimal regimens for minimization of exposure to irritants and pruritogens and other harmful exposures.

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Section: Air Pollutantsmentioning

confidence: 99%

Environmental risk factors and their role in the management of atopic dermatitis

Kantor

Silverberg

2016

Expert Review of Clinical Immunology

278

225

View full text Add to dashboard Cite

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“…Several studies have investigated the effect that air pollutants have on skin damage, focusing their interest especially on PM and ozone. These reported that outdoor air pollution is a relevant risk factor for the development of atopic dermatitis, a chronic inflammatory skin disease, and noted a cause-effect relationship between air pollution and skin quality [5,19]. At the cellular level, PM induces skin oxidative stress, leading to ROS and causing the secretion of pro-inflammatory cytokines.…”

Section: Discussionmentioning

confidence: 99%

Schisandra chinensis Protects the Skin from Global Pollution by Inflammatory and Redox Balance Pathway Modulations: An In Vitro Study

et al. 2018

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Abstract:Epidemiological results show that airborne particulate matter (PM) induces health alterations in line with pulmonary and cardiovascular pathologies. Deleterious effects of PM on the skin have also been investigated. A possible approach to prevent Reactive Oxygen Species (ROS)-mediated disorders for both preventive and treatment means is based on the use of substances, which can be found in plants. These can act as secondary metabolites, and lignans are a promising candidate. Thus, the objective of this study was firstly to identify reconstructed human epidermis, using a transcriptomic approach, and also to identify the effects of Urban Dust and of Urban Dust and Schisandra chinensis (S.C.) extract on the expression of genes that are involved in the response to cellular protection mechanisms. Secondly, we examined the effect of an active extract from S.C. on the protection of human keratinocytes damages that were caused by pollution, through the evaluation of Nrf2 and AhR pathways, NF-kB, and DJ-1. Urban Dust included the over-expression of metalloproteinases MMP-1 and MMP-9 and an increase in Glutathione peroxidase 2 (GPX2). In the presence of Urban Dust, S.C. extract activated the over-expression of several genes that are involved in the antioxidant response and in the detoxification pathway, including Ferritin light chain (FTL) and GPX2. Exposure to urban dust activated the cytoplasmic expression of NF-kB and AhR, when compared to the control. Co-treatment of Urban Dust and S.C. extract increased DJ-1 protein levels, Nrf2 expression, and decreased AhR and NF-kB in the cytoplasm. At the same time, this co-treatment increased SOD2 expression (50%: p < 0.001) and catalase activity (120%: p < 0.05), when compared to Urban Dust alone. Thus, S.C. might be able to protect the Normal Human Epidermal Keratinocytes (NHEK) from environmental aggression, by fighting the harmful effects of urban pollution.

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“…In addition to the effects on healthy skin, a number of studies have shown that outdoor air pollution is a relevant risk factor for the development of atopic dermatitis, a chronic inflammatory skin disease, and can also exacerbate this condition [32][33][34]. As a consequence, the prevalence of atopic dermatitis in urban areas is significantly higher compared to that of rural areas [34].…”

Section: Introductionmentioning

confidence: 99%

Cosmetic Functional Ingredients from Botanical Sources for Anti-Pollution Skincare Products

Juliano

Magrini

2018

Cosmetics

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Air pollution is a rising problem in many metropolitan areas around the world. Airborne contaminants are predominantly derived from anthropogenic activities, and include carbon monoxide, sulfur dioxide, nitrogen oxides, volatile organic compounds, ozone and particulate matter (PM; a mixture of solid and liquid particles of variable size and composition, able to absorb and delivery a large number of pollutants). The exposure to these air pollutants is associated to detrimental effects on human skin, such as premature aging, pigment spot formation, skin rashes and eczema, and can worsen some skin conditions, such as atopic dermatitis. A cosmetic approach to this problem involves the topical application of skincare products containing functional ingredients able to counteract pollution-induced skin damage. Considering that the demand for natural actives is growing in all segments of global cosmetic market, the aim of this review is to describe some commercial cosmetic ingredients obtained from botanical sources able to reduce the impact of air pollutants on human skin with different mechanisms, providing a scientific rationale for their use.

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Symptoms of atopic dermatitis are influenced by outdoor air pollution

Cited by 173 publications

References 9 publications

Environmental risk factors and their role in the management of atopic dermatitis

Environmental risk factors and their role in the management of atopic dermatitis

Schisandra chinensis Protects the Skin from Global Pollution by Inflammatory and Redox Balance Pathway Modulations: An In Vitro Study

Cosmetic Functional Ingredients from Botanical Sources for Anti-Pollution Skincare Products

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