Symptoms of depression and diabetes‐specific emotional distress are associated with a negative appraisal of insulin therapy in insulin‐naïve patients with Type 2 diabetes mellitus. A study from the European Depression in Diabetes [EDID] Research Consortium

Makine, Ceylan; Karşıdağ, Çağatay; Kadıoğlu, Pınar; İlkova, Hasan; Karşıdağ, Kubilay; Skovlund, Søren E.; Snoek, Frank J.; Pouwer, Frans

doi:10.1111/j.1464-5491.2008.02606.x

Cited by 80 publications

(80 citation statements)

References 14 publications

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“…Heterogeneity found in the evaluation of cases was high (I²=95.6%; τ²= 0.5506; p<0.0001). Of the included studies, three were conducted in Europe [30][31][32], six in Asia [33][34][35][36][37][38], and nine in the Americas (North, Central and South) [39][40][41][42][43][44][45][46][47]. (Figure 2) Sensitivity analyses were performed for each country in order to examine the heterogeneity.…”

Section: Resultsmentioning

confidence: 99%

Association Between Major Depression And Type 2 Diabetes Mellitus: A Meta-Analysis And Meta-Regression Of Observational Studies

et al. 2016

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The purpose of this review was to identify the prevalence of major depression in individuals with type 2 diabetes by means of a systematic review and meta-analysis. An electronic search was conducted for relevant studies published from January 1988 to December 2014. Cross-sectional and case-control studies in adults that evaluated the prevalence of major depression in individuals with type 2 Diabetes Mellitus were included. Meta-regression and sensitivity analyses were used to identify the sources of heterogeneity. Publication bias was assessed using a funnel plot and Egger's test. After the selection process, 18 cross-sectional and four case-control studies were included in the meta-analysis. In total, the occurrence of major depression was investigated in 5554 patients with diabetes mellitus type 2. The prevalence of major depression varied from 6.67% (95% CI: 4.54% -9.38%) to 55.38% (95% CI: 42.53% -67.73%), with an overall average of 21.13% (95% CI: 15.80% -27.66%). In American continent, the prevalence was 20.83% (95% CI: 13.12% -31.43%; I²=96.8%), and in Europe it was 18.00% (95% CI: 8.58% -33.91%; I²=93.8%). Both were lower than the rate in Asia, which was 23.49% (95% CI: 15.63% -33.74%; I²=90.8%). Meta-regression analysis found no evidence that the analyzed cofactors represented the cause of the heterogeneity seen. The approximately symmetrical distribution of the points in Funnel Plot suggests an absence of publication bias that was confirmed by Egger's test (p=0.2345). Based on the data collected, we can infer that the prevalence of major depression in individuals with type 2 diabetes was high, independent of geographic location.

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Section: Resultsmentioning

confidence: 99%

Association Between Major Depression And Type 2 Diabetes Mellitus: A Meta-Analysis And Meta-Regression Of Observational Studies

et al. 2016

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“…[26]. In a previous study, women tended to have more negative perceptions of insulin therapy than did men [27,28,29]. Gender difference in social support may also influence insulin acceptance.…”

Section: Discussionmentioning

confidence: 99%

Patients' perspectives on taking insulin in diabetes - Perspectives of convergence

Song¹,

Ah²

2016

Journal of Digital Convergence

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The purpose of this study was to explore the cultural perspectives and experiences relating to insulin therapy among the diabetes. The authors conducted four semi-structured focus groups and individual interviews with 19 adults with type 1 and 2 diabetes, focusing on the personal experiences and thoughts regarding insulin therapy. Patients' perspectives and experiences relating to taking insulin formed three categories of themes: preoccupations about insulin, barriers to taking insulin, and benefits to taking insulin. The theme for preoccupations about insulin was "vague fear," while the theme of barriers to taking insulin were "worrisome insulin-related issues", "ambivalent feelings (trust/mistrust) about healthcare providers," "dependent life," "feeling about supporters(family, friends, and religion)," "inconvenience," "regret about the past," and "embarrassment." The theme of benefits to taking insulin were "recognition" and "physical recovery and confidence in regulating blood glucose". Based on this study, patients' feelings about their insulin should be respected by healthcare providers.

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“…Diabetes management among persons with ITDM may be more complicated than among persons with NITDM. These persons need to closely monitor blood glucose and manage insulin use on a daily basis and are, perhaps, more vulnerable to diabetes-related depression [11][12][13][14], and have worsening depressive symptoms (among those with MDD) [15]. Because of the severity of depression, persons with ITDM may be vulnerable to self-monitoring their blood glucose less frequently than they should [16] and to subsequent diabetes complications [11,15].…”

Section: Introductionmentioning

confidence: 99%

Medical expenditures associated with major depressive disorder among privately insured working-age adults with diagnosed diabetes in the United States, 2008

Shrestha

Zhang

et al. 2013

Diabetes Research and Clinical Practice

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Aim-We aimed at estimating excess medical expenditures associated with major depressive disorder (MDD) among working-age adults diagnosed with diabetes, disaggregated by treatment mode: insulin-treated diabetes (ITDM) or non-insulin-treated diabetes (NITDM).Methods-We analyzed data for over 500,000 individuals with diagnosed diabetes from the 2008 U.S. MarketScan claims database. We grouped diabetic patients first by treatment mode (ITDM or NITDM), then by MDD status (with or without MDD), and finally by whether those with MDD used antidepressant medication. We estimated annual mean excess outpatient, inpatient, prescription drug, and total expenditures using regression models, controlling for demographics, types of health coverage, and comorbidities.Results-Among persons having ITDM, the estimated annual total mean expenditure for those with no MDD (the comparison group) was $19,625. For those with MDD, the expenditures were $12,406 (63%) larger if using antidepressant medication and $7322 (37%) larger if not using antidepressant medication. Among persons having NITDM, the corresponding estimated expenditure for the comparison group was $10,746, the excess expenditures were $10,432 (97%) larger if using antidepressant medication and $5579 (52%) larger if not using antidepressant medication, respectively. Inpatient excess expenditures were the largest of total excess expenditure for those with ITDM and MDD treated with antidepressant medication; for all others with diabetes and MDD, outpatient expenditures were the largest excess expenditure.Conclusions-Among working-age adults with diabetes, MDD was associated with substantial excess medical expenditures. Implementing the effective interventions demonstrated in clinical trials and treatment guidelines recommended by professional organizations might reduce the economic burden of MDD in this population.

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Symptoms of depression and diabetes‐specific emotional distress are associated with a negative appraisal of insulin therapy in insulin‐naïve patients with Type 2 diabetes mellitus. A study from the European Depression in Diabetes [EDID] Research Consortium

Cited by 80 publications

References 14 publications

Association Between Major Depression And Type 2 Diabetes Mellitus: A Meta-Analysis And Meta-Regression Of Observational Studies

Association Between Major Depression And Type 2 Diabetes Mellitus: A Meta-Analysis And Meta-Regression Of Observational Studies

Patients' perspectives on taking insulin in diabetes - Perspectives of convergence

Medical expenditures associated with major depressive disorder among privately insured working-age adults with diagnosed diabetes in the United States, 2008

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