Symptoms of depression in older adults with multiple sclerosis (MS): Comparison with a matched sample of younger adults

Kneebone, Ian; Dunmore, Emma; Evans, Edris

doi:10.1080/1360786031000101148

Cited by 33 publications

(21 citation statements)

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“…Several studies found no significant gender-related difference in the incidence of depression [6,15,34]. Several community and tertiary centre studies have reported that older patients with MS report fewer symptoms of depression than younger patients [15,30,35]. We did not find any correlations between depression and patient age or gender.…”

Section: Resultscontrasting

confidence: 44%

Correlations between depression, cognitive status, functional scores, disability and lesion load in multiple sclerosis treated with interferon beta 1a

Maier

Bălaşa

Bajkó

et al. 2015

Acta Medica Marisiensis

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Introduction: Depression and cognitive impairment are the most frequent mental disorders in multiple sclerosis (MS) and represent an important cause of morbidity and mortality. The aim of the study was to analyse the main determinants of depression in multiple sclerosis. Materials and methods: Thirty-two patients with relapsing remitting multiple sclerosis (RRMS), treated with Interferon Beta 1a, without relapses and corticosteroid treatment in the last 30 days, were included in the study. The mean age of the patients was 35.4±9.2 years, M/F ratio 0.33. Depression level was evaluated by the Romanian version of Beck Depression Inventory (BDI) and the cognitive function with Paced Auditory Serial Addition Test 3 (PASAT 3), Symbol Digit Modalities Test (SDMT). The functional status and disability level of the patients were evaluated with Multiple Sclerosis Functional Composite and Expanded Disability Status Scale. In all patients a cerebral MRI with intravenous contrast administration was performed using a 1.5T MRI device. Results: Twenty-three patients were free of depression (score 1-10), 4 patients presented mild mood disturbance (score 11-16), 3 borderline clinical depression (score 17-20) and 2 moderate depression (score 21-30). The mean BDI score was 8.71±7.16. BDI score correlated significantly with EDSS (R=0.38, p=0.03), PASAT 3 (R=-0.42, p=0.01), SDMT (R=-0.58, p=0.0007), Timed 25-Foot Walk (R=0.43, p=0.01) and 9-Hole Peg Test (R=0.45, p=0.008). From the EDSS functional scores, significant correlations were found with the urinary score (R=0.4, p=0.01) and sensitive score (R=0.49, p=0.004). BDI score correlated significantly with the total number of T2 lesions (R=0.31, p=0.05) while there was no correlation with the number of active lesions. Conclusions: The main determinants of depression in RRMS patients are the cognitive impairment, the affection of fine hand movements (9-HP), gait impairment (T25FT) and bladder and sensitive dysfunction.

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Section: Resultscontrasting

confidence: 44%

Correlations between depression, cognitive status, functional scores, disability and lesion load in multiple sclerosis treated with interferon beta 1a

Maier

Bălaşa

Bajkó

et al. 2015

Acta Medica Marisiensis

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“…However, in the Galeazzi et al (2005) study, age was not associated with either a current or past episode of MDD. Compared with older individuals with MS (M = 70), younger persons (M = 46) scored significantly higher on a measure of depressive symptoms (t (26) = 2.41, p <.05), indicating that they experienced more of these symptoms (Kneebone, Dunmore, & Evans, 2003).…”

Section: Primary Progressive Ms (Ppms)mentioning

confidence: 99%

Depression in Multiple Sclerosis: A Longitudinal Analysis

Beal

Stuifbergen

Brown

2007

Archives of Psychiatric Nursing

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High rates of depression are documented in persons with multiple sclerosis (MS), but few studies examine depression over time. This analysis considered data from 607 persons with MS over a sevenyear period as part of an ongoing longitudinal study of quality of life in chronic illness. Latent growth curve analysis was used to examine trajectories in depression and the effects of covariates such as age, time since diagnosis of MS, type of MS, and functional limitations on the extent to which depression changed over the study period. The results of the analysis indicated that depressive symptoms fluctuated over time for individuals but did not show a tendency to an overall significant increase or decrease for the group as a whole. Younger age, longer time since diagnosis of MS, progressive forms of MS and greater extent of functional limitation were predictive of greater depressive symptoms at Time 1. With the exception of functional limitation, which showed an association with depression at all time periods, these variables did not predict the changes in depressive symptoms over time. Gender was not a significant predictor of changes in depressive symptoms, nor did women have higher rates of depression as expected from previous research. The results of this analysis indicate the importance of screening for depression in all persons with MS.Multiple sclerosis (MS) is a chronic demylinating disease of the central nervous system that affects women 2-3 times more often than men (Noonan, Kathman & White, 2002). A higher incidence of depressive symptoms and major depressive disorder in persons with MS is well documented, and reported in both large community surveys (Chwastiak et al., 2002;Patten, Beck, Williams, Barbui, & Metz, 2003) and studies of persons with MS (Sadovnick et al., 1996). Depressive symptoms are associated with reduced quality of life for persons with MS (Fruehwalk, Loeffler-Stastka, Eher, Saletu & Baumhackl, 2001;Lobentanz et al., 2004) and with an increased risk of suicide (Faber, 2003; Sadovnick, Eisen, Paty, & Ebers, 1991).An important unresolved issue is whether depressive symptoms remain stable or fluctuate over time because most studies on this topic are cross-sectional. Therefore, additional longitudinal studies to describe the course of depressive symptoms and associated risk factors are warranted (Ehde & Bombardier, 2005). Learning more about the trajectory of depressive symptoms over time has implications for identification and treatment of depression in persons with MS. In particular, the influence of gender, age at MS onset, and severity of MS on the association between MS course and depression need further study (Zabad, Patten, & Metz, 2005).To respond to these issues, the purpose of this study was to explore the trajectory of depressive symptoms over a seven-year time period in a sample of persons with MS. We examined the correlations between the characteristics of change in depressive symptoms and the moderating Corresponding author: Claudia Beal, 5108 Lake Jackson Drive, Waco, ...

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“…These include cognitive biases towards negative information and attributions and unhelpful or negative beliefs about oneself, the world and the future. However, only a handful of studies have been conducted so far (20)(21)(22)(23)(24) and these factors have not been studied in relation to broader adjustment outcomes such as social and role functioning and quality of life. Another variable deemed worthy of exploration is people's beliefs about experiencing and expressing negative emotions.…”

mentioning

confidence: 99%

Cognitive and behavioural correlates of different domains of psychological adjustment in early-stage multiple sclerosis

Dennison

Moss‐Morris

Silber

et al. 2010

Journal of Psychosomatic Research

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Objective: This study investigated a cognitive-behavioural model of adjustment to Multiple Sclerosis (MS). It aimed to determine the contribution of cognitions and behaviours to the explanation of two distinct adjustment outcomes above and beyond measures of MS severity. Illness-related functional impairment was anticipated to be most strongly related to unhelpful thoughts and behaviours that were specific to MS and the experience of symptoms. Psychological distress was hypothesised to be most strongly related to more general unhelpful cognitions about the self and emotions.Methods: 94 people with MS completed questionnaires. Correlations and hierarchical multiple regressions determined the relative contribution of illness severity, cognitions, and behaviours to the prediction of psychological distress and functional impairment.Results: Illness-related functional impairment was related to disease severity, progressive vs. relapsing-remitting disease and unhelpful illness perceptions and cognitive and behavioural responses to symptoms. Illness severity factors accounted for a significant 23.7% of the variance in functional impairment (p<.001). Cognitive and behavioural variables explained a further 22.6% of variance (p<.001) with behavioural responses to symptoms emerging as the strongest predictor. The correlates of distress were unhelpful beliefs about the self, unhelpful beliefs about emotions, acceptance, and unhelpful cognitive responses to symptoms and illness perceptions. Illness severity factors explained only 2.2% of the variance in distress (p>.05) while cognitive and behavioural variables accounted for 37.1% (p<.001). Unhelpful beliefs about the self were the strongest predictor. Conclusion:Longitudinal and experimental research is required to investigate potential causal relationships. However, the cognitions and behaviours identified as important for adjustment are potentially modifiable, so may be useful to address within interventions for adjustment to MS.

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Symptoms of depression in older adults with multiple sclerosis (MS): Comparison with a matched sample of younger adults

Cited by 33 publications

References 0 publications

Correlations between depression, cognitive status, functional scores, disability and lesion load in multiple sclerosis treated with interferon beta 1a

Correlations between depression, cognitive status, functional scores, disability and lesion load in multiple sclerosis treated with interferon beta 1a

Depression in Multiple Sclerosis: A Longitudinal Analysis

Cognitive and behavioural correlates of different domains of psychological adjustment in early-stage multiple sclerosis

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