Symptoms of irritable bowel syndrome in ulcerative colitis in remission

Isgar, Brian; Harman, M; Kaye, M D; Whorwell, Peter J.

doi:10.1136/gut.24.3.190

Cited by 235 publications

(131 citation statements)

References 3 publications

Supporting

Mentioning

121

Contrasting

Unclassified

Order By: Relevance

“…There is evidence that GI inflammation may precipitate IBS symptoms. Patients with inflammatory bowel disease, particularly ulcerative colitis, experience higher than expected levels of symptoms compatible with IBS when in remission [Isgar et al 1983], and this may be due to continued subclinical low-grade inflammation [Keohane et al 2010]. Ongoing postinflammatory dysmotility has also been demonstrated in inflammatory bowel disease patients [LoeningBaucke et al 1989].…”

Section: Pathogenesis Of Irritable Bowel Syndromementioning

confidence: 99%

Treatment of irritable bowel syndrome: beyond fiber and antispasmodic agents

Sainsbury

Ford

2010

Therap Adv Gastroenterol

View full text Add to dashboard Cite

Irritable bowel syndrome (IBS) is a chronic functional disorder of the gastrointestinal tract of unknown etiology. The diagnosis of IBS is made clinically, using symptom-based criteria such as the Manning or Rome criteria. Medical therapy for this condition has traditionally been directed towards symptom relief, using fiber or antispasmodic agents. In recent years, emerging data have confirmed the efficacy of antidepressants, psychological therapies, 5-HT 3 antagonists, 5-HT 4 agonists, and probiotics in the short-term treatment of IBS, although whether these therapies influence the long-term course of the disease is unknown. Increasing knowledge regarding the pathophysiological mechanisms underlying IBS has resulted in a number of novel molecular treatments, which show promise. These include therapies targeting gastrointestinal mucosal chloride channels and guanylate cyclase-C receptors, as well as highly selective agents influencing serotonergic transmission that, at the time of writing, do not appear to have any severe deleterious effects. In this article we provide a summary of current and emerging therapies in this field.

show abstract

Section: Pathogenesis Of Irritable Bowel Syndromementioning

confidence: 99%

Treatment of irritable bowel syndrome: beyond fiber and antispasmodic agents

Sainsbury

Ford

2010

Therap Adv Gastroenterol

View full text Add to dashboard Cite

show abstract

“…The definition of remission in IBD is not straightforward, as it is a broad concept that includes several aspects: (1) clinical remission (absence of symptoms); (2) endoscopic remission (mucosal healing); and (3) deep remission (no symptoms and mucosal healing).…”

Section: How Do I Know That Ibd Is In Remission?mentioning

confidence: 99%

“…From 1983 until 2014 a total of 19 studies have measured the prevalence of IBS-like symptoms in IBD [1][2][3][4][5][33][34][35][42][43][44][45][46][47][48][49][50][51][52] . Two of these publications refer to the same IBD cohort [34,49] , leaving 18 prevalence estimations.…”

Section: How Many Ibd Patients In Remission Have Ibs-like Symptoms?mentioning

confidence: 99%

“…Manning criteria only [1,53] and the last one uses a validated gastrointestinal symptom questionnaire [2] . The range of reported prevalences is quite wide (11%-64%), also in CD (12%-68%) and in UC (9%-60%) separately.…”

Section: How Many Ibd Patients In Remission Have Ibs-like Symptoms?mentioning

confidence: 99%

“…More than thirty years ago, in 1983, it was first reported that a significant proportion of patients with inflammatory bowel disease (IBD) with normal mucosa in endoscopic examination nevertheless suffered from gastrointestinal symptoms allegedly of functional origin [1] . Almost twenty years passed until the next significant investigation addressing this issue was published, in 2002 by Simrén et al [2] .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Diagnosis and management of functional symptoms in inflammatory bowel disease in remission

Teruel

Garrido

Mesonero

2016

WJGPT

View full text Add to dashboard Cite

it in the present work. We describe a problematic that comprises physiopathological uncertainties, diagnostic difficulties, as IBS-like symptoms are very similar to those produced by an inflammatory flare, and the necessity of appropriate management of these patients, who, although in remission, have impaired quality of life. Ultimately, from almost a philosophical point of view, the presence of IBS-like symptoms in IBD patients in remission supposes a challenge to the traditional functional-organic dichotomy, suggesting the need for a change of paradigm. Core tip: Many inflammatory bowel disease patients in remission suffer from ongoing gastrointestinal symptoms that resemble those of irritable bowel syndrome and that hinder their quality of life. We review the pathogenesis of these symptoms, their prevalence and the best management strategies. Author contributions: All authors contributed equally to this work. Conflict-of-interest statement:The authors declare no conflicts of interest. AbstractInflammatory bowel disease (IBD) patients in remission may suffer from gastrointestinal symptoms that resemble irritable bowel syndrome (IBS). Knowledge on this issue has increased considerably in the last decade, and it is our intention to review and summarize REVIEWSubmit a

show abstract

Irritable Bowel, Mitral Valve Prolapse, and Associated Conditions

Thompson¹

1985

JAMA

View full text Add to dashboard Cite

Symptoms of irritable bowel syndrome in ulcerative colitis in remission

Cited by 235 publications

References 3 publications

Treatment of irritable bowel syndrome: beyond fiber and antispasmodic agents

Treatment of irritable bowel syndrome: beyond fiber and antispasmodic agents

Diagnosis and management of functional symptoms in inflammatory bowel disease in remission

Irritable Bowel, Mitral Valve Prolapse, and Associated Conditions

Contact Info

Product

Resources

About