Symptoms related to ADHD observed in patients with pervasive developmental disorder

Ogino, T.; Hattori, Junri; Abiru, Kiyoko; Nakano, Kousuke; Oka, Eiji; Ohtsuka, Yoko

doi:10.1016/j.braindev.2004.09.006

Cited by 24 publications

(22 citation statements)

References 15 publications

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“…The ADHD group comprised all children with this diagnosis, without regard to possible subtypes (predominantly inattentive, predominantly hyperactive-impulsive, or the combined type). Contrary to the DSM-IV-TR guidelines, but in accord with suggestions in the literature (Frazier et al 2001;Goldstein and Schwebach 2004;Ogino et al 2005;Yoshida and Uchiyama 2004), some of the children had been diagnosed with a combination of PDD-NOS and ADHD. A criterion for being included in the research groups was that PDD-NOS, ADHD or a combination of the two had to be the sole diagnosis.…”

Section: Participantsmentioning

confidence: 79%

“…An increasing number of researchers, however, challenge the idea that PDD precludes ADHD and vice versa, and argue that a double diagnosis is justified in some cases (Frazier et al 2001;Goldstein and Schwebach 2004;Ogino et al 2005;Yoshida and Uchiyama 2004). It remains a prominent question, therefore, whether PDD-NOS, ADHD, and the combination of the two are distinct diagnostic categories.…”

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confidence: 99%

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Differentiating Among Children with PDD-NOS, ADHD, and those with a Combined Diagnosis on the Basis of WISC-III Profiles

Scheirs

Timmers

2008

J Autism Dev Disord

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Pervasive Developmental Disorder-Not Otherwise Specified (PDD-NOS) and Attention Deficit/ Hyperactivity Disorder (ADHD) have partly overlapping symptoms. It can also be debated whether a third diagnostic category exists: children with a combined diagnosis. In this study an attempt was made to distinguish among the three groups on the basis of intelligence (WISC-III) profiles. It was found that the PDD-NOS group had higher verbal and performance IQ's, as well as higher WISC-III index scores than the ADHD group. Subtests Block Design and Mazes discriminated best. It was concluded that based on intelligence scores, only PDD-NOS and ADHD emerged as distinct categories, whereas the combined diagnosis did not. Future research on the distinctiveness of these diagnostic groups, however, should include variables other than IQ.

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Section: Participantsmentioning

confidence: 79%

mentioning

confidence: 99%

Differentiating Among Children with PDD-NOS, ADHD, and those with a Combined Diagnosis on the Basis of WISC-III Profiles

Scheirs

Timmers

2008

J Autism Dev Disord

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“…First, the CBCL criteria for ADHD problems are derived from DSM-IV, but DSM-IV itself has low sensitivity for assessing the inattentiveness of preschool-aged children. 87 Second, a very small number of children included in the final analyses had scores exceeding the clinical cutoff point (n = 9), which resulted in large CIs. Nevertheless, the finding is consistent with other neurotoxicant studies that reported significant risk for behavioral disorders associated with prenatal lead and ETS exposures 88 and alcohol and cocaine.…”

Section: Discussionmentioning

confidence: 99%

Impact of Prenatal Chlorpyrifos Exposure on Neurodevelopment in the First 3 Years of Life Among Inner-City Children

et al. 2006

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OBJECTIVE-The purpose of this study was to investigate the impact of prenatal exposure to chlorpyrifos on 3-year neurodevelopment and behavior in a sample of inner-city minority children.METHODS-As part of an ongoing prospective cohort study in an inner-city minority population, neurotoxicant effects of prenatal exposure to chlorpyrifos were evaluated in 254 children through the first 3 years of life. This report examined cognitive and motor development at 12, 24, and 36 months (measured with the Bayley Scales of Infant Development II) and child behavior at 36 months (measured with the Child Behavior Checklist) as a function of chlorpyrifos levels in umbilical cord plasma.RESULTS-Highly exposed children (chlorpyrifos levels of >6.17 pg/g plasma) scored, on average, 6.5 points lower on the Bayley Psychomotor Development Index and 3.3 points lower on the Bayley Mental Development Index at 3 years of age compared with those with lower levels of exposure. Children exposed to higher, compared with lower, chlorpyrifos levels were also significantly more likely to experience Psychomotor Development Index and Mental Development Index delays, attention problems, attention-deficit/hyperactivity disorder problems, and pervasive developmental disorder problems at 3 years of age. CONCLUSIONS-The adjusted mean 36-month Psychomotor Development Index and MentalDevelopment Index scores of the highly and lower exposed groups differed by only 7.1 and 3.0 points, respectively, but the proportion of delayed children in the high-exposure group, compared with the low-exposure group, was 5 times greater for the Psychomotor Development Index and 2.4 times greater for the Mental Development Index, increasing the number of children possibly needing early intervention services. NIH Public Access Author ManuscriptPediatrics. Author manuscript; available in PMC 2012 July 06. As a result of heavy indoor use, largely for cockroach control, pesticide exposure is widespread among pregnant women living in New York City. [3][4][5][6][7][8] Specifically, 72% to 85% of women participating in 2 different cohort studies reported using some form of pest control during pregnancy, 3,7-9 and 46% reported using ≥1 of the higher-toxicity methods, such as exterminator sprays, can sprays, and pest bombs. 3 A survey of pest control measures conducted in 2000 and 2001 by the office of the New York State Attorney General found that 93% of New York City public housing residents applied pesticides at home and more than one half did so approximately once per week. 6 In a previous report from the present cohort, detectable levels of chlorpyrifos were found in 99.7% of personal air samples and 100% of indoor air samples from stationary residential monitors for a sample of pregnant women. 8 Chlorpyrifos was also detected in 64% to 70% of blood samples collected from mothers and newborns at delivery. Maternal levels and newborn levels were correlated strongly, which indicates that this pesticide crosses the placenta readily. 3 Since the ban, levels of chlorpyr...

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“…Additionally, ADHD symptoms have been found to further impair overall psychiatric adjustment and functioning in children with ASD (Frazier et al, 2001; Gadow, DeVincent, & Pomeroy, 2006; Goldstein & Schwebach, 2004; Lecavalier, et al, 2009; Yoshida & Uchiyama, 2004). ADHD symptoms comorbid with ASD place children at a higher risk for psychiatric hospitalization (Frazier et al, 2001), predict more difficulties with general life functioning (Goldstein and Schwebach, 2004; Ogino et al, 2005; Yerys et al, 2009), and are positively correlated with receiving mental health services (Bryson, et al, 2008). Previous research also suggests that comorbid ADHD may exacerbate externalizing behavior problems within the pediatric ASD symptom profile (Yerys et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

ADHD severity as it relates to comorbid psychiatric symptomatology in children with Autism Spectrum Disorders (ASD)

Mansour

Dovi

Lane

et al. 2017

Research in Developmental Disabilities

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Comorbid diagnoses identified in pediatric samples have been correlated with a range of outcomes, including greater levels of emotional, behavioral, and educational impairment and the need for more intensive treatment. Given that previous research has documented high levels of comorbid Attention-Deficit/Hyperactivity Disorder (ADHD) in children with Autism Spectrum Disorders (ASD), this study closely examines the relationship between parent-reported ADHD symptoms (i.e., Conners' Parent Rating Scale, Revised [CPRS-R]) and the prevalence of additional comorbid psychiatric diagnoses in a pediatric ASD sample (n = 99). Regression analyses revealed that greater severity of ADHD symptomatology was significantly related to a greater number of comorbid psychiatric diagnoses, as identified using the Diagnostic Interview for Children and Adolescents, 4th Edition (DICA-IV). Additionally, more severe ADHD symptoms were also associated with higher levels of symptom severity on Child Behavior Checklist (CBCL) syndrome subscales. Interestingly, increasing severity of ASD symptomatology, as measured by the Autism Diagnostic Interview, Revised (ADI-R), was not associated with a higher prevalence of comorbid psychiatric diagnoses or CBCL syndrome severity. Our study concluded that higher levels of ADHD severity-not ASD severity-were associated with a higher prevalence of comorbid psychiatric symptomatology in school-age children with ASD. These findings may encourage clinicians to thoroughly assess ADHD symptomatology in ASD children to better inform treatment planning.

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Symptoms related to ADHD observed in patients with pervasive developmental disorder

Cited by 24 publications

References 15 publications

Differentiating Among Children with PDD-NOS, ADHD, and those with a Combined Diagnosis on the Basis of WISC-III Profiles

Differentiating Among Children with PDD-NOS, ADHD, and those with a Combined Diagnosis on the Basis of WISC-III Profiles

Impact of Prenatal Chlorpyrifos Exposure on Neurodevelopment in the First 3 Years of Life Among Inner-City Children

ADHD severity as it relates to comorbid psychiatric symptomatology in children with Autism Spectrum Disorders (ASD)

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