Symptoms Suggestive of Gastroparesis in a Community-Based Cohort of European Americans and African Americans with Type 2 Diabetes Mellitus

Brown, Landon; Xu, Jianzhao; Freedman, Barry I.; Hsu, Fang‐Chi; Bowden, Donald W.; Koch, Kenneth L.

doi:10.1007/s10620-019-05974-z

Cited by 4 publications

(2 citation statements)

References 38 publications

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“…Certain oral hypoglycemic drugs may cause gastrointestinal symptoms in patients with diabetes. Studies have shown that metformin treatment was significantly associated with gastrointestinal symptoms in DGP patients [32]. However, we didn't get the same conclusion in the present study.…”

Section: Discussioncontrasting

confidence: 94%

Analysis of gastric electrical rhythm in patients with type 2 diabetes mellitus

Wang,

Ma,

Jiang

et al. 2024

Endocrine

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Aim To analysis the change of electrogastrogram (EGG) in patients with type 2 diabetes mellitus (T2DM), and evaluate the prevalence of abnormal gastric electrical rhythm (AGER) and its relative influencing factors. Methods A total of 65 patients with T2DM hospitalized at the Second Affiliated Hospital of Soochow University from Dec. 2020 to Dec. 2021 were included in the cross-sectional study. General information, clinical data, and medical history data of all study subjects, including name, gender, body mass index (BMI), duration of diabetes, anti-diabetic therapies, high blood pressure (HBP) history, smoking history, and medication history, were completely collected. The results of laboratory tests, including biochemical parameters, glycosylated hemoglobin (HbA1c), fasting C-peptide, 2 h postprandial C-peptide, 24 h urine total protein (24 hUTP), urine microalbumin creatinine ratio (UACR) and estimated glomerular filtration rate (eGFR) were recorded. EGG, Gastroparesis Cardinal Symptom Index (GCSI), gastric emptying ultrasound, fundus examination, carotid artery ultrasonography, cardiac autonomic function test, heart rate variability (HRV) were all examined and recorded as well. According to the results of EGG, the subjects were divided into normal gastric electrical rhythm (NGER) group and abnormal gastric electrical rhythm (AGER) group. Results (1) Fasting blood glucose (FBG), HbA1c, the presence of diabetic peripheral neuropathy (DPN) and diabetic cardiac autonomic neuropathy (DCAN) were significantly higher in the AGER group (p < 0.05). Low frequency (LF) and high frequency (HF), the indicators of HRV, were significantly lower in the AGER group (p < 0.05). In addition, the prevalence of feeling excessively full after meals, loss of appetite, and stomach or belly visibly larger after meals of gastrointestinal symptoms of gastroparesis were significantly higher in the AGER group (p < 0.05). Multiple logistic regression analysis showed that FBG and the prevalence of DCAN were the independent risk factors. Conclusion AGER was associated with high FBG and the presence of DCAN. EGG examination is recommended for patients with gastrointestinal symptoms and clues of DCAN.

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Section: Discussioncontrasting

confidence: 94%

Analysis of gastric electrical rhythm in patients with type 2 diabetes mellitus

Wang,

Ma,

Jiang

et al. 2024

Endocrine

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“…It is known, that GI symptoms are prevalent in T2DM [5,19,25,26], but the exact mechanisms of this process are still unknown. Results of some studies suggest that GI symptoms predominate in women with DM more than in men [19,[25][26][27], but these studies were focused on symptoms itself, not on specific GI pathology. Speaking specifically about gastritis, Yang et al observed more severe forms of inflammation exactly in male patients with T2DM, not in females [28].…”

Section: Discussionmentioning

confidence: 99%

Do H. Pylori Status and Small Intestinal Bacterial Overgrowth Determine the Clinical Course of Chronic Active Gastritis in Patients With Type 2 Diabetes Mellitus?

2020

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The aim: To define clinical peculiarities of chronic active gastritis in patients with type 2 diabetes mellitus (T2DM) considering Helicobacter pylori (HP) status and small intestinal bacterial overgrowth (SIBO). Materials and methods: 172 patients with chronic active gastritis were enrolled in the study, 92 out of them had concomitant T2DM. Symptoms were collected with the questionnaire, HP infection was diagnosed with stool antigen test, SIBO was assessed with glucose hydrogen breath test. Results: 87.5% (n=70) patients with chronic gastritis without DM had epigastric pain, however those with T2DM reported pain only in 41.3% (n=38) cases. Other symptoms included: nausea, bloating, early satiety, postprandial fullness, heartburn, belching and vomiting. HP infection in patients with chronic gastritis and concomitant T2DM is significantly associated with symptoms of epigastric pain (OR=2.78, 95%CI 0.92-8.41), bloating (OR=3.92, 95%CI 1.40-10.99), nausea (OR=2.32, 95%CI 0.85-0.6.30), postprandial fullness (OR=1.45, 95%CI 0.54-3.87) and belching (OR=1.01, 95%CI 0.32-3.16), whereas SIBO – with bloating (OR=8.82, 95%CI 2.88-27.01), nausea (OR=5.15, 95%CI 1.88-14.10) and belching (OR=2.53, 95%CI 0.67-9.52). Conclusions: Patients with T2DM and chronic active gastritis report epigastric pain significantly less than non-diabetics. HP infection probably plays a prominent role in development of epigastric pain in patients with T2DM. Additionally, HP is linked to SIBO, which may lead to bloating, belching and nausea onset.

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