The mantle is known to be heterogeneous, mainly composed of peridotite and eclogite.Eclogite-derived hydrous melts may interact with harzburgite at the slab-mantle interface in subduction zones or in the sub-continental lithospheric mantle. In this study, such interactions were simulated by performing hybrid experiments in which a layer of eclogite has been juxtaposed to a layer of harzburgite, in the presence of H 2 O-CO 2 at 4 GPa and 1200 o C, conditions where eclogite is super-solidus while harzburgite is sub-solidus. A diamond trap was placed in between the two layers in order to trap the fluid or melt phase, allowing direct determination of their composition. The multi-anvil was rotated in different frequencies in order to examine the effect of increasing degree of interaction on the melt composition as well as the mineral compositions. The interaction of eclogite-derived hydrous melt and harzburgite results in a reaction layer at the interface between the two lithologies, composed of opx and garnet. The harzburgite above the reaction layer is metasomatized, containing various This is the peer-reviewed, final accepted version for American Mineralogist, published by the Mineralogical Society of America.The published version is subject to change. Cite as Authors (Year) Title. American Mineralogist, in press.